Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones.

Gustafsson, Bengt; Zangger, P.

doi:10.1113/jphysiol.1978.sp012191

Cited by 21 publications

(13 citation statements)

References 24 publications

(43 reference statements)

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“…In two preceding papers the a.h.p. properties of DSCT neurones were described Gustafsson & Zangger, 1978). In order to evaluate the role of the a.h.p.…”

Section: A Dsct Model Neuronementioning

confidence: 99%

“…conductance evoked by each spike is unaffected by the succeeding spikes; i.e. there is a linear superposition of successive a.h.p.s (Gustafsson & Zangger, 1978).…”

Section: A Dsct Model Neuronementioning

confidence: 99%

“…conductance evoked by the first spike (to allow for the introduction of a.h.p. depression ;Gustafsson & Zangger, 1978).…”

Section: A Dsct Model Neuronementioning

confidence: 99%

“…In two preceding papers the a.h.p. properties of dorsal spinocerebellar tract (DSCT) neurones has been described in some detail (Gustafsson, Lindstrom & Takata, 1978;Gustafsson & Zangger, 1978). Since earlier observations indicated that the repetitive firing of DSCT cells differs from that of motoneurones (Kuno & Miyahara, 1968;Eide et al 1969), the repetitive firing of DSCT cells evoked by current injection has now been re-investigated.…”

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confidence: 99%

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Firing behaviour of dorsal spinocerebellar tract neurones.

Gustafsson¹,

Linström²,

Zangger³

1978

The Journal of Physiology

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1. The repetitive discharge evoked by constant current injection from an intracellular micropipette has been studied in dorsal spinocerebellar tract cells of the cat. 2. The discharge frequency decreased with time, the decrease being more pronounced at high current intensities. Most of the frequency change occurred during the first ten intervals but the decrease continued slowly for several seconds. In some cells the frequency rose initially, the first interspike interval being larger than immediately succeeding ones. 3. The frequency-current (f/I) curves for the first interspike intervals were S-shaped, as found in spinal motoneurones. With successive intervals the lower leg of the f/I curve extended to higher frequencies, giving a progressive linearization of the f/I curves. In almost all cells this linearization was completed at 200 msec after current onset. 4. The experimental f/I curves were compared with the f/I curves obtained with a simple neurone model based on the properties of the postspike afterhyperpolarization. For the first interspike interval there was a good agreement between the experimental and calculated f/I curves of individual neurones up to frequencies of several hundred impulses per second. In the high frequency range, it was necessary to compensate for changes in initial postspike voltage trajectories caused by the injected current. Other aspects of the firing of real neurones, such as the progressive linearization of the f/I curves, the negative adaptation and the changes in the interspike voltage trajectories with increasing current were also reproduced by the neurone model. 5. It is concluded that the conductance process underlying the postspike afterhyperpolarization is a major factor in the regulation of repetitive firing in dorsal spinocerebellar tract neurones.

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“…In two preceding papers the a.h.p. properties of DSCT neurones were described Gustafsson & Zangger, 1978). In order to evaluate the role of the a.h.p.…”

Section: A Dsct Model Neuronementioning

confidence: 99%

“…conductance evoked by each spike is unaffected by the succeeding spikes; i.e. there is a linear superposition of successive a.h.p.s (Gustafsson & Zangger, 1978).…”

Section: A Dsct Model Neuronementioning

confidence: 99%

“…conductance evoked by the first spike (to allow for the introduction of a.h.p. depression ;Gustafsson & Zangger, 1978).…”

Section: A Dsct Model Neuronementioning

confidence: 99%

mentioning

confidence: 99%

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Firing behaviour of dorsal spinocerebellar tract neurones.

Gustafsson¹,

Linström²,

Zangger³

1978

The Journal of Physiology

Self Cite

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“…In contrast, motoneurones with accelerating firing patterns showed a decrease in the AHP amplitude during successive spikes. Gustafsson & Zangger (1978) have shown that, in cat dorsal spinocerebellar tract neurones, changes in firing pattern could be explained by the presence of AHP summation or depression. Previously (Viana et al 1993b), we have demonstrated that the AHP conductance in HMs is due to activation of an apamin-sensitive calcium-activated K+ conductance (Barrett & Barrett, 1976).…”

Section: Changes In Current Thresholdmentioning

confidence: 99%

Repetitive firing properties of developing rat brainstem motoneurones.

Viana

Bayliss

Berger

1995

The Journal of Physiology

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1. The repetitive firing properties of neonatal and adult rat hypoglossal motoneurones (HMs) were investigated in a brainstem slice preparation. Neonatal HMs could be classified into two main groups: (1) neurones with a decrementing or adapting firing pattern (type D), exhibiting an early and a late phase; and (2) neurones with an incrementing or accelerating firing pattern (type I). 2. The pattern of repetitive firing changed markedly during development. While most HMs recorded from young rats (P21), nearly all HMs had a decrementing firing pattern, characterized by a brief period of adaptation and high steadystate firing rates. 3. The calcium-dependent after-hyperpolarization (AHP) was shortest in type I neonatal HMs, and decreased in amplitude during trains of action potentials (APs). In type D neurones, these same trains caused a slight enhancement of AHP amplitude. In adult HMs, with a decrementing firing pattern, trains of APs also caused summation of the AHP. 4. Type D neonatal HMs showed a progressive prolongation of the AP during repetitive firing.In contrast, type I neonatal HMs had almost no change in AP duration. In adult HMs the AP was short and experienced only a modest increase in duration during fast repetitive firing. 5. The function relating steady-state firing frequency to injected current (f-I curve) was linear. The mean steady-state f-I slope was significantly higher in neonates than in adults (-30 vs. -20 Hz nA-'), and was weakly correlated with input resistance. The f-I slope was negatively correlated with AHP duration in neonatal HMs only. In addition, for a given AHP duration the slope was higher in neonatal HMs. 6. Two threshold behaviours were observed among neonatal HMs: (a) a progressive rhythmic firing threshold, and (b) a sudden transition from subthreshold to regular repetitive firing. Current threshold for repetitive firing was strongly correlated with cell input conductance. Type I neonatal HMs had higher minimal steady firing rates (fmin) than type D HMs. In neonates, fmin was strongly correlated with AHP duration. Adult HMs showed a weaker correlation between these two parameters, and fmin was higher than predicted by AHP duration. 7. In summary, HMs responded to depolarizing current pulses with different firing patterns during postnatal development. Changes in intrinsic membrane properties, including the calcium-dependent AHP conductance, play a role in the repetitive firing patterns displayed by HMs and therefore may influence how these motoneurones transform synaptic input into spike output.

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