Effect of repeated methamphetamine administrations on dopamine and glutamate efflux in rat prefrontal cortex

Stephans, Stacy E.; Yamamoto, Bryan K.

doi:10.1016/0006-8993(95)00938-m

Cited by 101 publications

(66 citation statements)

References 50 publications

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“…Furthermore, K ϩ -stimulated glutamate efflux in the mPFC was enhanced in animals after repeated methamphetamine exposure (Stephans and Yamamoto, 1995). Repeated co-SENSITIZATION AND REINSTATEMENT caine was shown to produce time-dependent increases in cocaine-mediated mPFC glutamate overflow, short (but not long) withdrawals from repeated cocaine exposure being associated with cocaine-induced increases in extracellular glutamate concentrations in the mPFC (Williams and Steketee, 2004).…”

Section: Neurochemistry/neuropharmacologymentioning

confidence: 90%

Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior

2011

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Section: Neurochemistry/neuropharmacologymentioning

confidence: 90%

Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior

2011

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“…In this case, NE may have a leading role in sustaining the behavioural effects produced by METH administration [72]. This also occurs partly in the ventral striatum and specific limbic regions, which are rich in both DA and NE axon terminals [67, 93-96]. …”

Section: Molecular Effects Of Methamphetamine (Meth) On Catecholaminementioning

confidence: 99%

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Ferrucci

Giorgi

Bartalucci

et al. 2013

Current Neuropharmacology

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The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

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“…Whereas repeated cocaine administration produces robust drug-induced glutamate sensitization within the NAC [e.g., 31,35,47,57], repeated dosing with non-toxic regimens of amphetamine or methamphetamine elicits little effect upon the capacity of these drugs to alter glutamate levels within the corticoaccumbens pathway [61,272]. In contrast, repeated high dose amphetamine or methamphetamine regimens that induce dopamine neurotoxicity produce an increase in glutamate content within the PFC [273], a delayed increase in dorsal and ventral striatal glutamate levels [60,[274][275][276][277] and enhance potassium-stimulated, but not methamphetaminestimulated, glutamate release within the PFC [277]. Whether or not the more modest effects of amphetamine regimens upon corticoaccumbens glutamate relate to the duration of withdrawal remains to be determined.…”

Section: Homers and Methamphetaminementioning

confidence: 99%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.

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Effect of repeated methamphetamine administrations on dopamine and glutamate efflux in rat prefrontal cortex

Cited by 101 publications

References 50 publications

Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior

Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Homers regulate drug-induced neuroplasticity: Implications for addiction

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