Effect of Repeated Inhalation of Vapors of Industrial Solvents on Animal Behavior I. Evaluation of Nine Solvent Vapors on Pole-Climb Performance in Rats

Me, Goldberg; He, J.; Uc, Pozzani; Hf, Smyth

doi:10.1080/00028896409342606

Cited by 51 publications

(11 citation statements)

References 4 publications

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“…category for the surviving animals is censored. Other animal studies reported gross signs of CNS effects, such as loss of coordination (26) and anesthe~ia,'~~,~~) both of which were considered adverse, and swimming immobility,cZ9) for which a 10% change from control was used to identify an adverse effect. A 20% change in motor activity was considered adverse.…”

Section: Resultsmentioning

confidence: 99%

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene¹

et al. 1997

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Exposure-response analysis of acute noncancer risks should consider both concentration (C) and duration (T) of exposure, as well as severity of response. Stratified categorical regression is a form of meta-analysis that addresses these needs by combining studies and analyzing response data expressed as ordinal severity categories. A generalized linear model for ordinal data was used to estimate the probability of response associated with exposure and severity category. Stratification of the regression model addresses systematic differences among studies by allowing one or more model parameters to vary across strata defined, for example, by species and sex. The ability to treat partial information addresses the difficulties in assigning consistent severity scores. Studies containing information on acute effects of tetrachloroethylene in rats, mice, and humans were analyzed. The mouse data were highly uncertain due to lack of data on effects of low concentrations and were excluded from the analysis. A model with species-specific concentration intercept terms for rat and human central nervous system data improved fit to the data compared with the base model (combined species). More complex models with strata defined by sex and species did not improve the fit. The stratified regression model allows human effect levels to be identified more confidently by basing the intercept on human data and the slope parameters on the combined data (on a C x T plot). This analysis provides an exposure-response function for acute exposures to tetrachloroethylene using categorical regression analysis.

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Section: Resultsmentioning

confidence: 99%

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene¹

et al. 1997

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“…For example, a study conducted by Goldberg and colleagues (Goldberg et al, 1964), suggests that tolerance to the acute behavioral effects of acetone vapors (6000 ppm) develops after a few sessions in rats. Further, Glowa and colleagues (Glowa, 1987;Glowa et al, 1986) reported that acute exposure to 3000 ppm of acetone vapors reduced the rate of responding under an FI (fixed interval) schedule in rats, and Geller et al, (1979) reported variable differences in FR (fixed ratio) and FI response rates of rats exposed to 150 ppm.…”

Section: Resultsmentioning

confidence: 99%

The effects of inhaled acetone on place conditioning in adolescent rats

Lee

Pai

Mullapudui

et al. 2008

Pharmacology Biochemistry and Behavior

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Introduction-Acetone is a ubiquitous ingredient in many household products (e.g., glue solvents, air fresheners, adhesives, nail polish, and paint) that is putatively abused; however, there is little empirical evidence to suggest that acetone alone has any abuse liability. Therefore, we systematically investigated the conditioned response to inhaled acetone in a place conditioning apparatus.Method-Three groups of male, Sprague-Dawley rats were exposed to acetone concentrations of 5,000, 10,000 or 20,000 ppm for 1 hour in a conditioned place preference apparatus alternating with air for 6 pairing sessions. A place preference test ensued in an acetone-free environment. To test the preference of acetone as a function of pairings sessions, the 10,000 ppm group received an additional 6 pairings and an additional group received 3 pairings. The control group received air in both compartments. Locomotor activity was recorded by infrared photocells during each pairing session.Results-We noted a dose response relationship to acetone at levels 5,000-20,000 ppm. However, there was no correlation of place preference as a function of pairing sessions at the 10,000 ppm level. Locomotor activity was markedly decreased in animals on acetone-paired days as compared to air-paired days.Conclusion-The acetone concentrations we tested for these experiments produced a markedly decreased locomotor activity profile that resemble CNS depressants. Furthermore, a dose response relationship was observed at these pharmacologically active concentrations, however, animals did not exhibit a positive place preference.

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“…At non-lethal concentrations, acute effects on the central nervous system were reported. In rats, slight alterations of behavioural response were described following a single 4-h exposure to 6,000 ppm (Goldberg et al 1964). In mice, subtle changes in neurobehavioural tests were reported following acute exposure to 2,580 ppm (de Ceaurriz et al 1983) or 3,200 ppm (Glowa and Dews 1987).…”

Section: Acetonementioning

confidence: 96%

Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits

Arts

Heer

Woutersen

2005

Int Arch Occup Environ Health

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Subjective measures alone are less appropriate for establishing sensory irritation thresholds of odorous irritants and are, therefore, less suitable to establish OELs without supporting evidence. Objectively measured irritation in humans, the Alarie assay (an experimental animal test assessing the concentration that results in a 50% reduction of the breathing frequency) and repeated exposure studies in animals may be of help to study objective irritation. If subjective measurements are used to study sensory irritation, the study design should at least include: measurement of both incidence and severity determined at several concentrations, an appropriate (0 ppm) control condition, preferably a non-irritant odorant control exposure, validated questionnaires and correct concentration measurements.

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Effect of Repeated Inhalation of Vapors of Industrial Solvents on Animal Behavior I. Evaluation of Nine Solvent Vapors on Pole-Climb Performance in Rats

Cited by 51 publications

References 4 publications

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene¹

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene¹

The effects of inhaled acetone on place conditioning in adolescent rats

Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits

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Effect of Repeated Inhalation of Vapors of Industrial Solvents on Animal Behavior I. Evaluation of Nine Solvent Vapors on Pole-Climb Performance in Rats

Cited by 51 publications

References 4 publications

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene1

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene1

The effects of inhaled acetone on place conditioning in adolescent rats

Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits

Contact Info

Product

Resources

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Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene¹

Categorical Regression Analysis of Acute Exposure to Tetrachloroethylene¹