Effect of repeated cold stress on intensity of lipid peroxidation and tissue antioxidant system

Emirbekov, E Z; L'vova, S. P.; Гасангаджиева, А. Г.

doi:10.1007/bf02499150

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…The most significant increase in SOD activity, induced by stress, was detected in the liver in our study. Increase in SOD activity suggests that cold stress may increase the rate of O -generation and subsequently H 2 O 2 formation (Emirbekov et al, 1998;Liu et al, 2000). All parts of the nervous system contain SODs: enzymes that remove superoxides by catalyzing their dismutations with one superoxide being reduced to H 2 O 2 and another oxidized to O 2 (Liochev and Fridovich, 2005).…”

Section: Discussionmentioning

confidence: 99%

Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Eşrefoğlu¹,

Akıncı²,

Elbe³

et al. 2014

Turk J Biol

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In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.

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Section: Discussionmentioning

confidence: 99%

Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Eşrefoğlu¹,

Akıncı²,

Elbe³

et al. 2014

Turk J Biol

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show abstract

“…Selman et al found that cold exposure (8 °C; 18 days) increased catalase activity in myocardial tissue of small mammals ( Microtus agrestis ) without altering superoxide dismutase activity [ 100 ] . Emirbekov et al observed that cold adaptation (-5 °C; 3 h; during 20–25 days) decreased the MDA level in the myocardium and increased total antioxidant activity in the myocardial tissue of rats[ 101 ]. We found that a free radical scavenger, N-2-mercaptopropionylglycine, abolished the infarct-reducing effect of cold adaptation [unpublished data].…”

Section: Introductionmentioning

confidence: 99%

Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury

Voronkov,

Popov,

Naryzhnaya

et al. 2024

IBJ

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Ascorbic acid and beta-carotene reduce stress-induced oxidative organ damage in rats

Eşrefoğlu

Akıncı

Taşlıdere

et al. 2016

Biotechnic & Histochemistry

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Antioxidants are potential therapeutic agents for reducing stress-induced organ damage. We investigated the effects of ascorbic acid and β-carotene on oxidative stress-induced cerebral, cerebellar, cardiac and hepatic damage using microscopy and biochemistry. Male Wistar albino rats were divided into five groups: untreated control, stressed, stressed + saline, stressed + ascorbic acid and stressed + β-carotene. The rats in the stressed groups were subjected to starvation, immobilization and cold. The histopathological damage scores for the stressed and stressed + saline groups were higher than those of the control group for all organs examined. The histopathological damage scores and mean tissue malondialdehyde levels for the groups treated with antioxidants were lower than those for the stressed and stressed + saline groups. Mean tissue superoxide dismutase activities for groups that received antioxidants were higher than those for the stressed + saline group for most organs evaluated. Ascorbic acid and β-carotene can reduce stress-induced organ damage by both inhibiting lipid oxidation and supporting the cellular antioxidant defense system.

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Effect of repeated cold stress on intensity of lipid peroxidation and tissue antioxidant system

Abstract: Repeated cold stress performed in a cold-tempering mode reduces lipid peroxidation and activates tissue antioxidant system.

Cited by 3 publications

References 2 publications

Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury

Ascorbic acid and beta-carotene reduce stress-induced oxidative organ damage in rats

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