Effect of repeated administration of lipopolysaccharide on inflammatory and stress markers in saliva of growing pigs

Escribano, Damián; Campos, Paulo Henrique Reis Furtado; Gutiérrez, Ana María; Floc'H, Nathalie Le; Cerón, José J.; Merlot, Elodie

doi:10.1016/j.tvjl.2014.04.007

Cited by 28 publications

(39 citation statements)

References 41 publications

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“…Likewise, the release of TXB 2 and the marked elevation of the pulmonary arterial pressure was greatly reduced (Klosterhalfen et al, 1992). Additionally, CRP levels in porcine saliva are suggested to be tolerance subjective (Escribano et al, 2014).…”

Section: Endotoxin Tolerancementioning

confidence: 99%

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Wyns

Plessers

Backer

et al. 2015

Veterinary Immunology and Immunopathology

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Section: Endotoxin Tolerancementioning

confidence: 99%

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Wyns

Plessers

Backer

et al. 2015

Veterinary Immunology and Immunopathology

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“…IgA has been described as a stress biomarker in rats [117], dogs [118] and humans [119]. In pigs, an increase in saliva IgA has been reported after immobilization [84, 120], in endotoxemia [121], and after isolation [63]. In the case of isolation, IgA was more strongly affected than other markers such as cortisol and testosterone [63].…”

Section: Biomarkers Of Stress Studied In Pigsmentioning

confidence: 99%

Causes, consequences and biomarkers of stress in swine: an update

et al. 2016

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BackgroundIn recent decades there has been a growing concern about animal stress on intensive pig farms due to the undesirable consequences that stress produces in the normal physiology of pigs and its effects on their welfare and general productive performance. This review analyses the most important types of stress (social, environmental, metabolic, immunological and due to human handling), and their biological consequences for pigs. The physio-pathological changes associated with stress are described, as well as the negative effects of stress on pig production. In addition an update of the different biomarkers used for the evaluation of stress is provided. These biomarkers can be classified into four groups according to the physiological system or axis evaluated: sympathetic nervous system, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis and immune system.ConclusionsStress it is a process with multifactorial causes and produces an organic response that generates negative effects on animal health and production. Ideally, a panel of various biomarkers should be used to assess and evaluate the stress resulting from diverse causes and the different physiological systems involved in the stress response. We hope that this review will increase the understanding of the stress process, contribute to a better control and reduction of potential stressful stimuli in pigs and, finally, encourage future studies and developments to better monitor, detect and manage stress on pig farms.

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“…Moreover, recent studies performed over the enzyme adenosine deaminase (ADA) in saliva samples showed a powerful and cheap tool for health status assessment in pigs [5]. Other salivary biomarkers such as α-amylase [6], cortisol, chromogranin A, immunoglobulin A or testosterone [7] could be used as a practical and non-invasive tool for reflecting the activity of different physiological systems involved in the stress response and the immune system in pigs [8]. Furthermore, a penbased collection of oral fluids has been used to monitor the circulation of several pathogens, such as the porcine reproductive and respiratory virus (PRRS) [9], porcine circovirus Type 2 [10], influenza A virus [11] and Erysipelothrix rhusiopathiae [12].…”

Section: Introductionmentioning

confidence: 99%

Analytical characterization of trace elements (zinc, copper, cadmium, lead and selenium) in saliva of pigs under common pathological conditions in the field: a pilot study

Sánchez¹,

Montilla²,

Gutiérrez-Panizo³

et al. 2020

BMC Vet Res

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Background: This study is focused on the measurement of trace elements (zinc, copper, cadmium, lead and selenium) in the saliva of pigs in order to study their levels on different porcine pathological conditions in the field. The experiment involved 15 pigs without clinical signs of disease and 42 diseased pigs (suffering from lameness, rectal prolapse, fatigue or growth rate retardation). Individual saliva samples were collected, allowing the pigs to chew a sponge each for trace element quantifications through atomic absorption spectrometry (AAS). Since this is the first report on the measurements of trace elements in porcine saliva, a routine analytical validation study was performed for the quantification of all the studied elements. Moreover, the acute phase proteins C-reactive protein (CRP) and haptoblobin (Hp), the total antioxidant capacity (TAC) and adenosine deaminase (ADA) were quantified in the saliva samples for the animal's health status assessment. Results: Modifications in the levels of acute phase proteins or ADA were only recorded in animals with lameness and rectal prolapse and those with fatigue respectively. Moreover, TAC level changes were observed in pigs with growth-rate retardation. However, alterations in the levels of two or more trace elements were reported for all the different groups of diseased pigs with evident variations within pathologies. Conclusions:The salivary quantification of trace elements could be considered as a complementary tool to acute phase proteins, TAC and ADA determinations for disease detection and differentiation in the pig and should be explored in greater depth.

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Effect of repeated administration of lipopolysaccharide on inflammatory and stress markers in saliva of growing pigs

Cited by 28 publications

References 41 publications

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Causes, consequences and biomarkers of stress in swine: an update

Analytical characterization of trace elements (zinc, copper, cadmium, lead and selenium) in saliva of pigs under common pathological conditions in the field: a pilot study

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