Effect of renal transplantation on cognitive function in hemodialysis patients: a longitudinal study

Chhabra, Yogesh; Sood, Sanjay Kumar; Rathi, Omprakash; Mahajan, Sandeep

doi:10.1007/s11255-017-1700-1

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…Intradialytic cerebral blood flow decline has correlated with ultrafiltration volumes and a measurable decline in executive function. This persists in those who remained on dialysis but not those who undergo renal transplant ( 49 , 50 ). Compared to patients on PD, HD patients have worse cognitive function and higher rates of dementia ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Cognitive Impairment Early After Initiating Maintenance Hemodialysis: A Cross Sectional Study

et al. 2022

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BackgroundAbnormalities in cognitive function are almost universal in patients receiving hemodialysis (HD) and are associated with worse quality of life, impaired decision making, increased healthcare utilization and mortality. While cognitive impairment in the HD population is increasingly recognized, it is unclear how quickly it develops after starting HD.MethodsThis was a cross-sectional study of a cohort of low dialysis vintage HD patients (<12 months). We used the validated Cambridge Brain Science (CBS) battery of web-based tests to evaluate cognition compared to age- and sex matched controls across three cognitive domains: verbal processing, reasoning and short-term memory.ResultsForty-nine HD patients were included in this study; 43 completed the full battery of tests. The average scores for HD patients were consistently below the age and sex-matched controls. Fifty-five percent of HD patients had cognitive impairment in verbal skills, 43% in reasoning and 18% in short-term memory.ConclusionsThere is a high prevalence of CI evident early after starting HD, with the largest deficits seen in reasoning and verbal processing. These deficits may be attributable to the HD treatment itself. Further studies are needed to characterize the natural history of CI in this patient population and to test interventions aimed at preventing or slowing its progression.

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Section: Discussionmentioning

confidence: 99%

Cognitive Impairment Early After Initiating Maintenance Hemodialysis: A Cross Sectional Study

et al. 2022

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“…Cognitive function has been reported to improve with KTx; Chhabra et al [ 100 ] conducted a study measuring P300 in 20 KTx recipients aged 18–50 years before and 3 months after KTx. They demonstrated that P300 latency, which was prolonged before KTx, shortened to a level comparable to healthy subjects after KTx, and reported that cognitive function improved with an improvement in anemia.…”

Section: Measures For CI In Patients With Ckdmentioning

confidence: 99%

Cognitive Impairment and Brain Atrophy in Patients with Chronic Kidney Disease

Tsuruya,

Yoshida

2024

JCM

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In Japan, the aging of the population is rapidly accelerating, with an increase in patients with chronic kidney disease (CKD) and those undergoing dialysis. As a result, the number of individuals with cognitive impairment (CI) is rising, and addressing this issue has become an urgent problem. A notable feature of dementia in CKD patients is the high frequency of vascular dementia, making its prevention through the management of classical risk factors such as hypertension, diabetes mellitus, dyslipidemia, smoking, etc., associated with atherosclerosis and arteriosclerosis. Other effective measures, including the use of renin–angiotensin system inhibitors, addressing anemia, exercise therapy, and lifestyle improvements, have been reported. The incidence and progression of CI may also be influenced by the type of kidney replacement therapy, with reports suggesting that long-duration dialysis, low-temperature hemodialysis, peritoneal dialysis, and kidney transplantation can have a preferable effect on the preservation of cognitive function. In conclusion, patients with CKD are at a higher risk of developing CI, with brain atrophy being a contributing factor. Despite the identification of various preventive measures, the evidence substantiating their efficacy remains limited across all studies. Future expectations lie in large-scale randomized controlled trials.

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Neurocognitive Functioning in Pediatric Dialysis

Hooper

Hartung

2021

Pediatric Dialysis

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Effect of renal transplantation on cognitive function in hemodialysis patients: a longitudinal study

Abstract: ESKD patients have impaired CF as documented by prolonged P300 latencies. There was normalization of P300 latencies post-transplantation indicating role of uremic toxins in CF impairment.

Cited by 9 publications

References 30 publications

Cognitive Impairment Early After Initiating Maintenance Hemodialysis: A Cross Sectional Study

Cognitive Impairment Early After Initiating Maintenance Hemodialysis: A Cross Sectional Study

Cognitive Impairment and Brain Atrophy in Patients with Chronic Kidney Disease

Neurocognitive Functioning in Pediatric Dialysis

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