Effect of relative air humidity on the flowability of lactose powders

Lumay, Geoffroy; Traina, Karl; Boschini, Frèdéric; Delaval, Vincent; Rescaglio, Antonella; Cloots, Rudi; Vandewalle, Nicolas

doi:10.1016/j.jddst.2016.04.007

Cited by 30 publications

(16 citation statements)

References 29 publications

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“…The prediction of stickiness due to interaction with water at a certain temperature is a complicated task and not easily feasible for newly developed or modified products. Moreover, the fact that some quite recent publications deal with the subject of powder flow in relation to extrinsic conditions such as moisture and temperature confirms the relevance of the topic (Lumay G. et al, 2016;Emery E. et al, 2009). In these studies, however, typically the water content of the material was studied as the main descriptor rather than the impact of the relative humidity in the air, although current literature by Juarez-Enriquez E. et al (2017) strongly recommends that the latter option is much more appropriate.…”

Section: Introductionmentioning

confidence: 74%

See 1 more Smart Citation

Real-time in-situ Rheological Assessment of Sticky Point Temperature and Humidity of Powdered Products

Groen

Kooijman

Belzen

et al. 2020

KONA

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Unwanted changes in powder flow behavior can unexpectedly occur when a product is exposed to certain conditions of temperature and humidity. This can happen during production, but also during transport or storage. The work reported here demonstrates the novel approach of using an amended powder rheology setup for measuring and predicting such changes in powder flow behavior. The developed methodology makes it possible to vary in-situ the temperature and the relative humidity of the air to which the product is exposed, thereby mimicking realistic conditions of production or related unit operations. An air flow capable of fluidizing the powder particles is controlled at a specific constant temperature and its relative humidity can be altered while measuring the torque in the fluidized powder bed in real time. The fluidization is necessary for generating a homogeneous introduction of temperature and relative humidity. Results obtained using citric acid and commercial coffee whitener products have proven this methodology to provide both similar and in certain instances dissimilar results compared to the more established methodology such as measuring the vapour adsorption isotherms. These observations are explained. In this way, it can be predicted under which combinations of temperature and humidity a product does or does not become sticky. The main advantages of our approach are that the flow properties are directly assessed, the interpretation of the obtained data is more straightforward and that the measurement times are shortened substantially.

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Section: Introductionmentioning

confidence: 74%

“…Examples of materials that are sensitive towards stickiness are numerous and can be found throughout all industries, e.g. in the food industry (Juarez-Enriquez E. et al, 2017) but also in the pharmaceuticals (Lumay G. et al, 2016;Sandler N. et al, 2010) and chemicals industries (Stanford M.K. et al, 2002 andSun C., 2009).…”

Section: Introductionmentioning

confidence: 99%

Real-time in-situ Rheological Assessment of Sticky Point Temperature and Humidity of Powdered Products

Groen

Kooijman

Belzen

et al. 2020

KONA

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“…In this context, some authors propose to measure the standard deviation of the fluctuations of the flow interface in order to characterise the cohesive powders (e.g. Alexander et al, 2006;Lumay et al, 2012Lumay et al, , 2016. However, such dynamic tests are generally very challenging to interpret, as adhesive contacts cause clump formation, and adhesion and particle friction have a coupled effect on flow.…”

Section: Rotating Drummentioning

confidence: 99%

Cohesive Powder Flow: Trends and Challenges in Characterisation and Analysis

Ghadiri

Nan

Hare

et al. 2020

KONA

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Powder processing and manufacturing operations are rate processes for which the bottleneck is cohesive powder flow. Diversity of material properties, particulate form, and sensitivity to environmental conditions, such as humidity and tribo-electric charging, make its prediction very challenging. However, this is highly desirable particularly when addressing a powder material for which only a small quantity is available. Furthermore, in a number of applications powder flow testing at low stress levels is highly desirable. Characterisation of bulk powder failure for flow initiation (quasi-static) is well established. However, bulk flow parameters are all sensitive to strain rate with which the powder is sheared, but in contrast to quasi-static test methods, there is no shear cell for characterisation of the bulk parameters in the dynamic regime. There are only a handful of instruments available for powder rheometry, in which the bulk resistance to motion can be quantified as a function of the shear strain rate, but the challenge is relating the bulk behaviour to the physical and mechanical properties of constituting particles. A critique of the current state of the art in characterisation and analysis of cohesive powder flow is presented, addressing the effects of cohesion, strain rate, fluid medium drag and particle shape.

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“…[1][2][3][4] Electrostatic charging, van der Waal's interactions, and the formation of liquid bridges are all variable functions of moisture concentration, while the moisture content itself may again vary from material to material, and at different humidity conditions. Liquid bridge induced cohesion dominates the cohesive behavior at higher moisture contents, 5 whereas at low moisture contents electrostatic charging 6 and van der Waal's forces are the dominant interactions. 7 Flow behaviors may be further hindered by an increase in humidity due to the formation of solid bridges 8 and also due to phase changes in amorphous materials due to a decrease in glass-transition temperature.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Moisture-Induced Cohesion in Pharmaceutical Mixtures

Mukherjee

Sen

Fontana

et al. 2019

Journal of Pharmaceutical Sciences

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Moisture-induced flow variabilities in pharmaceutical blends lead to multiple impediments during manufacturing of solid dosage formulations. Processing and storage humidity conditions both govern the moisture contents of the pharmaceutical mixtures and bear significant impact on the final product quality. In this study, experimentally validated discrete element method-based computational models along with statistical formalism have been implemented to develop a predictive tool for moisture-induced cohesion in binary and tertiary mixtures. V-blending was applied to prepare the pharmaceutical blends, and mixing characterization was performed using a Raman PhAT probe. Optimum fill volume was established for the mixing conditions to minimize static charging due to blender wall interactions on the pharmaceutical powders. A simplex-centroid (augmented) design for 3-component system was implemented to predict and quantify the nonlinear behavior of moisture-induced cohesion between the pharmaceutical powders based on their systematic hopper discharge studies (experiments and simulations). A methodical implementation of these quantification tools was hence performed to validate a design space that enables an approach to the appropriate selection of blend concentrations that achieve minimum mixture flow variability across different humidity conditions.

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Effect of relative air humidity on the flowability of lactose powders

Cited by 30 publications

References 29 publications

Real-time in-situ Rheological Assessment of Sticky Point Temperature and Humidity of Powdered Products

Real-time in-situ Rheological Assessment of Sticky Point Temperature and Humidity of Powdered Products

Cohesive Powder Flow: Trends and Challenges in Characterisation and Analysis

Quantification of Moisture-Induced Cohesion in Pharmaceutical Mixtures

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