Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

Cichoń, Natalia; Synowiec, Ewelina; Miller, Elżbieta; Śliwiński, Tomasz; Ceremuga, Michał; Saluk‐Bijak, Joanna; Bijak, Michał

doi:10.3390/brainsci10050266

Cited by 17 publications

(6 citation statements)

References 43 publications

(63 reference statements)

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“…Berdasarkan literatur, paparan medan magnet ELF sebesar 730,56 𝜇𝑇 selama 60 menit dapat menurunkan nilai pH ikan bandeng sebagai indikator kualitas fisik dalam pengawetan ikan bandeng (Nurhasanah et al, 2018). Medan elektromagnetik frekuensi rendah dapat mempengaruhi pertumbuhan bakteri E-coli (Cichon et al, 2020).…”

Section: Pendahuluanunclassified

PENGARUH PAPARAN MEDAN MAGNET EXTREMELY LOW FREQUENCY (ELF) TERHADAP NILAI pH CABAI MERAH KECIL (Capsicum frutescens L)

Nuriyah¹,

Sudarti²,

Bektiarso³

2022

Orb. J. Pend. Ilm. Fis.

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ABSTRAKMedan maegnet Extremely Low Frequency (ELF) merupakan spektrum gelombang elektromagnetik dengan rentan frekuensi yang dimiliki sebesar 0 sampai kurang dari 0,3kHz dan termasuk dalam non-pengion radiation. Penelitian ini bertujuan untuk mengkaji pengaruh paparan medan magnet ELF terhadap pH cabai merah kecil (Capsicum futescens L). Jenis penelitian ini adalah penelitian eksperimen dengan desain yang digunakan RAL (Rancang Acak Lengkap). Sampel yang digunakan adalah cabai merah kecil dari jenis sret yang dibagi menjadi kelompok kontrol tanpa paparan medan magnet dan kelompok eksperimen dengan paparan medan magnet intensitas 600μT dan 1.000μT dengan lama paparan 30 menit, 60 menit dan 90 menit. Sampel yang digunakan sebanyak 145 kemasan sampel, dengan masing-masing kemasan berisi 5 buah cabai varietas sret kelas 3 dengan ukuran 4 < 8 cm. Kelompok kontrol ada 25 kemasan sampel dan kelompok ekperimen ada 120 kemasan sampel. Analisa data dilakukan dengan uji One Way Anova dengan uji LSD dan uji Kruskal-Wallis menggunakan IBM Statistics 23. Hasil penelitian didapatkan bahwa paparan medan magnet Extremely Low Frequency (ELF) berpengaruh terhadap nilai pH cabai merah kecil, dengan intensitas paparan 600μT selama 30 menit berpotensi dalam mempertahankan nilai pH cabai merah kecil. Kata kunci: medan magnet ELF; cabai merah (capsicum frutescens L); pH. ABSTRACTExtremely Low Frequency (ELF) magnetic field is a spectrum of electromagnetic waves with a frequency range of 0 to less than 0.3 kHz and is included in non-ionizing radiation. This study aims to examine the effect of exposure to the ELF magnetic field on the pH of small red chili (Capsicum futescens L). This type of research is experimental research with the design used RAL (Completely Randomized Design). The samples used were small red chilies of the sret type which were divided into a control group without exposure to a magnetic field and an experimental group with an intensity of 600μT and 1,000μT magnetic field exposure with an exposure duration of 30 minutes, 60 minutes and 90 minutes. The samples used were 145 sample packages, with each package containing 5 chilies of class 3 sret variety with a size of 4 < 8 cm. The control group had 25 sample packages and the experimental group had 120 sample packages. Data analysis was carried out by One Way Anova test with LSD test and Kruskal-Wallis test using IBM Statistics 23. The results showed that exposure to Extremely Low Frequency (ELF) magnetic fields affected the pH value of small red chilies, with an exposure intensity of 600μT for 30 minutes in maintaining the pH value of small red chilies. Keywords: ELF magnetic field; red chilies (capsicum frutescens L); pH.

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Section: Pendahuluanunclassified

PENGARUH PAPARAN MEDAN MAGNET EXTREMELY LOW FREQUENCY (ELF) TERHADAP NILAI pH CABAI MERAH KECIL (Capsicum frutescens L)

Nuriyah¹,

Sudarti²,

Bektiarso³

2022

Orb. J. Pend. Ilm. Fis.

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“…Considering activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are also thought to be involved in ferroptosis, we speculate that MF induced-ferroptosis may be also related with both ion channels and iron metabolism. Cichon et al report that low-frequency EMF could increase the expression of GPX4 and enhance the antioxidant defense of the body in poststroke patients, but they did not check the ferroptosis level of the cells (71,72). Last but not least, MF-boosted ferroptosis-like cell death is an important new strategy for cancer therapy.…”

Section: Immune Regulation By Iron Metabolism and The Effect Of Mfs Omentioning

confidence: 99%

Innate Immune Regulation Under Magnetic Fields With Possible Mechanisms and Therapeutic Applications

Lei

Pan

et al. 2020

Front. Immunol.

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With the wide applications of magnetic fields (MFs) in medicine, researchers from different disciplines have gained interest in understanding the effect of various types of MFs on living cells and organisms. In this paper, we mainly focus on the immunological and physical aspects of the immune responses and their mechanisms under different types of MFs. Immune cells were slightly affected by low-frequency alternating MFs but were strongly influenced by moderate-intensity MFs and high-gradient MFs (HGMFs). Larger immune cells, such as macrophages, were more sensitive to HGMFs, which biased the cell polarization into the anti-inflammatory M2 phenotype. Subject to the gradient forces of varying directions and strength, the elongated M2 macrophage also remodeled the cytoskeleton with actin polymerization and changed the membrane receptors and ion channel gating. These alterations were very similar to changes caused by the small GTPase RhoA interference in macrophage. Regulation of iron metabolism may also contribute to the MF effects in macrophages. High MFs were found to regulate the iron content in monocyte-/macrophage-derived osteoclasts by affecting the expression of iron-regulation genes. On the other hand, paramagnetic nanoparticles (NPs) combined with external MFs play an important role in T-cell immunity. Paramagnetic NP-coated Tcells can cluster their T-cell receptors (TCRs) by using an external MF, thus increasing the cell-cell contact and communication followed by enhanced tumor killing capacity. The external MF can also guide the adoptively transferred magnetic NP-coated T-cells to their target sites in vivo, thus dramatically increasing the efficiency of cell therapy. Additionally, iron oxide NPs for ferroptosis-based cancer therapy and other MF-related therapeutic applications with obstacles were also addressed. Furthermore, for a profound understanding of the effect of MFs on immune cells, multidisciplinary research involving both experimental research and theoretical modeling is essential.

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“…Besides, neuroregenerative effects of ELF‐EMF in hippocampus were reported by several studies (Cuccurazzu et al., 2010 ; Cuccurazzu et al., 2010 ; Sakhaie et al., 2017a ; Tasset et al., 2012 ). Furthermore, ELF‐EMF has been found to increase neuroplasticity (Cichon et al., 2020 ; Cuccurazzu et al., 2010 ). In this respect, ELF‐EMF can act like a double‐edged sword.…”

Section: Introductionmentioning

confidence: 99%

Effect of prenatal stress and extremely low‐frequency electromagnetic fields on anxiety‐like behavior in female rats: With an emphasis on prefrontal cortex and hippocampus

Hosseini

Kianifard

2023

Brain and Behavior

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Objective Prenatal stress (PS) is a problematic situation resulting in psychological implications such as social anxiety. Ubiquitous extremely low‐frequency electromagnetic fields (ELF‐EMF) have been confirmed as a potential physiological stressor; however, useful neuroregenerative effect of these types of electromagnetic fields has also frequently been reported. The aim of the present study was to survey the interaction of PS and ELF‐EMF on anxiety‐like behavior. Method A total of 24 female rats 40 days of age were distributed into four groups of 6 rats each: control, stress (their mothers were exposed to stress), EMF (their mothers underwent to ELF‐EMF), and EMF/stress (their mothers concurrently underwent to stress and ELF‐EMF). The rats were assayed using elevated plus‐maze and open field tests. Results Expressions of the hippocampus GAP‐43, BDNF, and caspase‐3 (cas‐3) were detected by immunohistochemistry in Cornu Ammonis 1 (CA1) and dentate gyrus (DG) of the hippocampus and prefrontal cortex (PFC). Anxiety‐like behavior increased in all treatment groups. Rats in the EMF/stress group presented more serious anxiety‐like behavior. In all treatment groups, upregulated expression of cas‐3 was seen in PFC, DG, and CA1 and downregulated expression of BDNF and GAP‐43 was seen in PFC and DG and the CA1. Histomorphological study showed vast neurodegenerative changes in the hippocampus and PFC. Conclusion The results showed ,female rats that underwent PS or/and EMF exhibited critical anxiety‐like behavior and this process may be attributed to neurodegeneration in PFC and DG of the hippocampus and possibly decreased synaptic plasticity so‐called areas.

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Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

Cited by 17 publications

References 43 publications

PENGARUH PAPARAN MEDAN MAGNET EXTREMELY LOW FREQUENCY (ELF) TERHADAP NILAI pH CABAI MERAH KECIL (Capsicum frutescens L)

PENGARUH PAPARAN MEDAN MAGNET EXTREMELY LOW FREQUENCY (ELF) TERHADAP NILAI pH CABAI MERAH KECIL (Capsicum frutescens L)

Innate Immune Regulation Under Magnetic Fields With Possible Mechanisms and Therapeutic Applications

Effect of prenatal stress and extremely low‐frequency electromagnetic fields on anxiety‐like behavior in female rats: With an emphasis on prefrontal cortex and hippocampus

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