Effect of Rehabilitation on Fatigue Level in Patients with Multiple Sclerosis

Mikuľáková, Wioletta; Klímová, Eleonóra; Kendrová, Lucia; Gajdoš, Miloslav; Chmelík, Marek

doi:10.12659/msm.909183

Cited by 13 publications

(11 citation statements)

References 31 publications

(44 reference statements)

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“…The improvements seen in the 2MWT (+17m) and TUG (‒2.1 s) exceed the reported minimum for clinically meaningful changes for the 2MWT (+9.1 m) [ 37 ] and the TUG (‒0.75 s) [ 38 ] and are in the range of other rehabilitation studies in MS reporting improvements of 14.8 m (35.1%) [ 13 ] for the 2MWT and ‒1.2 s (‒7.9%) for the TUG [ 39 ]. The improvement in fatigue (FSMC) by ‒6 points (‒9.4%) at the 3-month follow-up is in line with other studies, which showed a decrease in fatigue levels after rehabilitation [ 40 ] of ‒6.1 points (‒12.4%) evaluated with the Modified Fatigue Impact Scale. However, the 6 points (95% CI 2‒11) improvement in fatigue on the FSMC 3 months after rehabilitation compared with 1 week before rehabilitation in the current study is below the reported minimum for a clinical meaningful change of 9 points (95% CI ‒6.8‒11.2) reported by Svenningsson et al [ 41 ].…”

Section: Discussionsupporting

confidence: 89%

Three weeks of rehabilitation improves walking capacity but not daily physical activity in patients with multiple sclerosis with moderate to severe walking disability

Kuendig

Kool²,

Polhemus³

et al. 2022

PLoS ONE

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Background Patients with multiple sclerosis have low levels of physical activity. This is of concern because low activity levels are related to cardiovascular disease, poor walking ability, and reduced quality of life. The aim of this study was to evaluate the impact of rehabilitation on daily physical activity and walking capacity in patients with multiple sclerosis who have moderate to severe walking disability. Methods This exploratory, observational study of 24 patients with multiple sclerosis examined daily physical activity, walking capacity and fatigue before and after 3 weeks of inpatient rehabilitation. Inpatient rehabilitation included physiotherapy (30–60 min, 5 times/week), strength and endurance training (30–45 min, 3–5 times/week), occupational therapy (30 min, 2–3 times/week), and neuropsychological training (30 min, 2 times/week). There were no specific interventions to target daily levels of physical activity. Results Daily physical activity did not change after rehabilitation (physical activity: effect size = –0.23, 95% confidence interval (95% CI) 0.02‒0.62). There were significant improvements in walking capacity (Two-Minute Walk Test: effect size = 0.74, 95% CI 0.31‒1.16, +17 m, 20.2%) and mobility (Timed Up and Go Test: effect size = 0.65, 95% CI 0.22‒1.07, ‒2.1 s, 14.9%). Motor and cognitive fatigue (Fatigue Scale for Motor: effect size = 0.56, 95% CI 0.14‒0.99 and Cognitive Functions: effect size = 0.44, 95% CI 0.01‒0.86) improved significantly after rehabilitation. Conclusion Three weeks of rehabilitation improved walking capacity, but not daily physical activity, in patients with multiple sclerosis with moderate to severe walking disability. To increase physical activity, it may be necessary to add specific behavioural interventions to the rehabilitation programme. The intervention plan should include strategies to overcome personal and environmental barriers.

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Section: Discussionsupporting

confidence: 89%

Three weeks of rehabilitation improves walking capacity but not daily physical activity in patients with multiple sclerosis with moderate to severe walking disability

Kuendig

Kool²,

Polhemus³

et al. 2022

PLoS ONE

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“…Study by Michel cava et al conducted to investigate effect of rehabilitating treatments on fatigue in patients with MS; showed that complementary methods such as rehabilitating plans is effective in reducing fatigue in patients with MS (Mikulakova, Klimova, Kendrova, Gajdos, & Chmelik, 2018).…”

Section: Discussionmentioning

confidence: 99%

Evaluation the effect of progressive muscle relaxation technique on fatigue and daily living activities in patients with Multiple Sclerosis

Javdan¹,

Imani²,

Negahi³

2021

PJMHS

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Aim: This is a Quasi-experimental study wich was carried out in order to determine the effects of applying progressive muscle relaxation on fatigue and daily living activity of MS patients. Background: Fatigue is one of the most common symptoms in people with multiple sclerosis (MS) and adversely affects their daily living activities. Methods: 80 MS Patients were selected then conducted in two group (40 experiments and 40 contorol). Data collector tools included: demographic questionnaire, fatigue severity scale and activity of daily living questionnaire which completed four times by two group (before̦ Third week, sixth and ninth after study), self-report checklists which completed only by experimental group. PMRT performed once a day for 8 week by experimental group. During study no intervention was done for control group. Results: repeated measures ANOVA showed that there is significant difference in mean score of fatigue between two group in 4 times (P<0/05). Also, the results showed that with progressive muscle relaxation at 4 times, daily activities in ADL and IADL sections were significantly increased (P<0/05) but there was no significant difference between the two groups (P>0/05). however, clinically significant differences were observed. Conclusions: Acording to these findingș applying PMRT decreased patient´s fatigue and improve independence in daily living activities. This study supports the effect of PMRT on fatigue and activities of daily living in patients with MS, and it is recommended that further studies be conducted on this subject in the future. Keywords: daily living activity, fatigue, progressive muscle relaxation technique, multiple sclerosis.

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Section: Present Therapeutic Approachesmentioning

confidence: 99%

“…Another frequent symptom reported by MS patients is fatigue, which is encountered in 75–95% of cases [ 133 , 134 , 135 ] and is considered a key factor affecting the quality of life in these people [ 136 , 137 ]. Fatigue is defined as a perceived reduction in physical and mental energy that hinders everyday activities [ 135 ]. Physical exercise, especially aerobic training, can improve both primary and secondary fatigue in MS patients, through direct changes in the central nervous system and inflammation reduction, but also by improving depression symptoms and quality of sleep [ 138 ].…”

Section: Present Therapeutic Approachesmentioning

confidence: 99%

Neurorehabilitation in Multiple Sclerosis—A Review of Present Approaches and Future Considerations

Sîrbu¹,

Thompson

Pleşa

et al. 2022

JCM

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Multiple sclerosis is an increasingly prevalent disease, representing the leading cause of non-traumatic neurological disease in Europe and North America. The most common symptoms include gait deficits, balance and coordination impairments, fatigue, spasticity, dysphagia and an overactive bladder. Neurorehabilitation therapeutic approaches aim to alleviate symptoms and improve the quality of life through promoting positive immunological transformations and neuroplasticity. The purpose of this study is to evaluate the current treatments for the most debilitating symptoms in multiple sclerosis, identify areas for future improvement, and provide a reference guide for practitioners in the field. It analyzes the most cited procedures currently in use for the management of a number of symptoms affecting the majority of patients with multiple sclerosis, from different training routines to cognitive rehabilitation and therapies using physical agents, such as electrostimulation, hydrotherapy, cryotherapy and electromagnetic fields. Furthermore, it investigates the quality of evidence for the aforementioned therapies and the different tests applied in practice to assess their utility. Lastly, the study looks at potential future candidates for the treatment and evaluation of patients with multiple sclerosis and the supposed benefits they could bring in clinical settings.

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Effect of Rehabilitation on Fatigue Level in Patients with Multiple Sclerosis

Cited by 13 publications

References 31 publications

Three weeks of rehabilitation improves walking capacity but not daily physical activity in patients with multiple sclerosis with moderate to severe walking disability

Three weeks of rehabilitation improves walking capacity but not daily physical activity in patients with multiple sclerosis with moderate to severe walking disability

Evaluation the effect of progressive muscle relaxation technique on fatigue and daily living activities in patients with Multiple Sclerosis

Neurorehabilitation in Multiple Sclerosis—A Review of Present Approaches and Future Considerations

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