Dental caries or tooth decay is one of the most common chronic diseases in the world. Streptococcus mutans and Candida albicans species are the major etiological agent of caries. During the work, we had extracted the plants extract in the presence solvents by the help of Soxhlet extraction method. By this, we had obtained nearly 5 % of the extract. From these extract, we had moved for the isolation of pathogens from the samples collected from the patients, into which we had observed the pathogens similar to the Streptococcus mutans and Candida albicans. Fenugreek shows 3.6, Curcuma Longa shows good ZOI of 7.5, Zingiber Officinale shows 8.5 against chloroform, Allium Sativum shows ZOI of 6.5 against ethanol. When we perform their MIC it show that the best MIC was shown by Syzygium aromaticum, Allium Cepa and Curcuma Longa in the form of O.D. is 1.61, 1.55 and 1.33 respectively. Other extractants are also showing the better MIC as of Zingiber Officinale, Fenugreek and Allium Sativum shows 1.90, 2.10 and 2.22 respectively.