Effect of Regenerative Injection Therapy on Function and Pain in Patients with Knee Osteoarthritis: A Randomized Crossover Study

Abstract

The use of RIT is associated with a marked reduction in symptoms, which was sustained for over 24 weeks.

Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis

“…We excluded one single-arm trial, due to lack of quantitative pain evaluation in patients with patellar chondro-arthropathy,18 one RCT comparing single injection of dextrose with erythropoietin,19 one RCT targeting nonspecific chronic low back pain without definite radiologic evidence of lumbar spine osteoarthritis,20 and two observational studies analyzing data from a published RCT exploring knee osteoarthritis 21,22. The final meta-analysis included one single-arm follow-up trial23 and five RCTs,7,8,24–26 four of which probed knee osteoarthri tis7,23,24,26 and two of which examined hand osteoarthritis 8,25. Regarding the comparative injection regimens in the five RCTs, one used two serial saline injections followed by one shot of corticosteroids,25 three used sequential administrations of local anesthetics,7,8,24 and one used a crossover design by implementing the dextrose injection at different time points 26…”

“…The final meta-analysis included one single-arm follow-up trial23 and five RCTs,7,8,24–26 four of which probed knee osteoarthri tis7,23,24,26 and two of which examined hand osteoarthritis 8,25. Regarding the comparative injection regimens in the five RCTs, one used two serial saline injections followed by one shot of corticosteroids,25 three used sequential administrations of local anesthetics,7,8,24 and one used a crossover design by implementing the dextrose injection at different time points 26…”

“…As regards the quality assessment, all the RCTs obtained a maximal 2 points in the aspect of “randomization” in Jadad scale since appropriate randomization methods were mentioned. In the aspect of “blinding”, all the RCTs had appropriate blinding methods (maximal 2 points) except the study by Dumais et al26 which did not mention a blinded design of intervention and evaluation (earning 0 points). In the aspect of “an account of all patients”, the two studies conducted by Reeves and Hassanein,7,8 the one by Rabago et al,24 and the one by Dumais et al26 had descriptions of the outcome of all the patients at the end of the studies (earning 1 point).…”

Regenerative Sports Medicine: Past, Present, and Future (Adapted From the PASSOR Legacy Award Presentation; AAPMR; October 2016)

“…The remaining research is composed mostly of case series. Table 1 presents a list of studies [17‐47] and levels of evidence.…”

Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials

“…Randomized clinical trials [30,31] have compared HDP vs conservative treatments (physiotherapy, exercise program) in individuals with knee OA and have reported greater efficacy of HDP in terms of reducing pain and improving function. When analyzing the effectiveness of HDP in OA knee treatment vs other interventional treatments, HDP appeared to be more effective than local anesthetics [17,19,20].…”