Effect of Refractive Status and Axial Length on Peripapillary Retinal Nerve Fibre Layer Thickness: An Analysis Using 3D OCT

Sowmya, V.; Venkataramanan, V. R.; Prasad, K. P. Vishnu

doi:10.7860/jcdr/2015/14112.6480

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…In the current study, we found the Mean Axial Length in emmetropia as 23.07±0.38. Parvaresh et al 16 and Sowmya V et al 17 had similar values of emmetropia in their study, as against Singh et al 15 who had slightly lower values of axial length than our study. (Table 1)…”

Section: Axial Lengthsupporting

confidence: 83%

“…In our study, as the degree of myopia increased, the mean over-all RNFL thickness decreased. Similar results of mean average RNFL thickness in moderate and high myopes were shown by Singh et al 15 The NFL thickness was significantly lower in highly myopic eyes compared to emmetropic eyes as seen in similar studies by Parvaresh et al, 16 Sowmya V et al 17…”

Section: Nfl Thicknesssupporting

confidence: 77%

“…We found that as the degree of myopia increased, the Axial Length decreased. Sowmya V et al, 17 Parvaresh et al 16 and Singh et al 15 showed similar results in low, moderate and high myopic cases.…”

Section: Axial Lengthmentioning

confidence: 65%

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Evaluation of retinal nerve fibre layer thickness by optical coherence tomography in emmetropic and myopic patients

Tripathi¹,

Mehrotra²,

Chander³

et al. 2020

IJCEO

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In myopic eyes, the elongation of the globe leads to mechanical stretching and thinning of the retina. Therefore, it is conceivable that the extent of the elongation would be related to the degree of retinal thinning, although it is yet to be ascertained whether the retinal nerve fibre layer (RNFL) thickness is decreased at the histologic level. To evaluate RNFL by OCT in Emmetropic and Myopic patients and evaluate the relationship between RNFL thickness and the grade of myopia and Axial Length. The present study was carried out at the department of ophthalmology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad. Peripapillary RNFL thickness of all subjects were tabulated for group 1 (emmetropics) and Group 2 comparing them to grades of myopia, axial length, age, refractive status and cup disc ratio. The mean right and left side axial length was significantly more among myopic subjects compared to emmetropic subjects. The mean RNFL superior, Inferior, Temporal and Nasal was significantly more among emmetropic compared to low myopia which was significantly more than moderate myopia which was significantly more than high myopia thereby showing a decrease in the RNFL thickness with grades of myopia. We observed that with increasing grades of myopia the RNFL thickness decreased. On comparing emmetropes and myopes on the basis of axial length, we observed that with increasing axial length in various degrees of myopia, the average RNFL thickness also decreased in various quadrants.

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Section: Axial Lengthsupporting

confidence: 83%

Section: Nfl Thicknesssupporting

confidence: 77%

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Evaluation of retinal nerve fibre layer thickness by optical coherence tomography in emmetropic and myopic patients

Tripathi¹,

Mehrotra²,

Chander³

et al. 2020

IJCEO

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Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography

Tan

Liu

Zhang

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeWe investigated the feasibility of glaucoma detection by measuring retinal surface contour variability (RSCV) using optical coherence tomography (OCT).MethodsThe peripapillary region in one eye of each participant was scanned over an 8 × 8 mm area with a swept source OCT prototype. The retinal surface contour was sampled at approximately 1.5- to 3.5-mm radius circles centered on the optic nerve head. The RSCV is defined as the average log value within a middle spatial frequency band of the Fourier transform to the elevation profile of the inner retinal surface. The spatial frequency band was optimized to distinguish glaucoma from normal. Nerve fiber layer thickness (NFLT) was sampled around a 1.7-mm radius circle. Glaucoma severity was assessed by automated static perimetry.ResultsWe enrolled 17 glaucomatous eyes and 17 healthy eyes. A great majority of the glaucoma group were in the early stage (visual field mean deviation average −2.48 ± 3.73 dB). Significant differences were found for RSCV between glaucoma and control eyes (P < 0.003) at all radii. The area under the receiver operating characteristic curve (AROC = 0.90) of RSCV was best at the 3.5-mm radius. This was not significantly better than NFLT (AROC = 0.84). With the 99% specificity, the glaucoma detection sensitivity was 53% for RSCV and 29% for NFLT (P = 0.13).ConclusionsRetinal surface contour variability was significantly increased in glaucoma patients. The diagnostic accuracy of RSCV was equal to NFLT in early glaucoma. Since the RSCV detects small-scale focal damage and the average NFLT measures global damage, they provide different diagnostic information that may be synergistic.

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Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging

Tellouck

Durieux

Coupé

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Tellouck L, Durieux M, Coupé P, et al. Optic radiations microstructural changes in glaucoma and association with severity: a study using 3Tesla-magnetic resonance diffusion tensor imaging. Invest Ophthalmol Vis Sci. 2016;57:6539-6547. DOI:10.1167/iovs.16-19838 PURPOSE. To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. METHODS.A total of 50 open-angle glaucoma subjects and 50 healthy age-and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3.0-Tesla magnetic resonance imaging. Fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD), and axial diffusivity (AD) were quantified semiautomatically along the optical radiations. DTI parameters and volumes of specific brain structures were compared between cases and controls using conditional logistic regression. Association between DTI metrics and the severity of the disease was studied using linear mixed regression analyses. RESULTS.In glaucoma subjects, optic radiations FA was significantly lower (0.57 vs. 0.59; P ¼ 0.02) and RD was significantly higher (52.78 10 -5 mm 2 /s vs. 49.74 10 -5 mm 2 /s; P ¼ 0.03) than in controls. Optic radiations FA was significantly correlated with homolateral functional and structural damage of glaucoma (mean deviation of VF [P ¼ 0.03], retinal nerve fiber layer thickness [P ¼ 0.03], vertical cup to disc ratio [P ¼ 0.0007]). Volume and DTI parameters of other brain structures (including hippocampus) were not significantly different between glaucoma patients and controls.CONCLUSIONS. We evidenced microstructural modifications along visual pathways of glaucoma patients and these alterations were correlated with disease severity. The association of glaucoma with other neurodegenerative alterations would need further exploration and a prospective follow-up of our cohort of subjects. (ClinicalTrials.gov number, NCT01621841).

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Effect of Refractive Status and Axial Length on Peripapillary Retinal Nerve Fibre Layer Thickness: An Analysis Using 3D OCT

Cited by 9 publications

References 21 publications

Evaluation of retinal nerve fibre layer thickness by optical coherence tomography in emmetropic and myopic patients

Evaluation of retinal nerve fibre layer thickness by optical coherence tomography in emmetropic and myopic patients

Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography

Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging

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