Effect of Refined Edible Oils on Neurodegenerative Disorders

Abstract

Neurodegenerative diseases are comprise a prominent class of neurological diseases. Generally, neurodegenerative diseases cannot be cured, and the available treatments can only regulate the symptoms or delay the disease progression. Among the several factors which could clarify the possible pathogenesis of neurodegenerative diseases, next to aging as the main risk, the dietary related diseases are the most important. Vegetable oils, which are composed of triacyclglycerols as the main components and several other components in a trace amount, are the main part of our diet. This review aims to study the effect of refined or unrefined vegetable oil consumption as a preventive or aiding strategy to slow or halt the progression of neurodegenerative diseases. In the refining process, owing to the chemical materials or severe temperatures of the refining process, removal of the desirable minor components is sometimes unavoidable and thus a worrisome issue affecting physical and neurological health.

AMPK signaling pathway as a potential therapeutic target for Parkinson's disease

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease caused by the loss of dopaminergic neurons. 1 - 3 In 2016, it was estimated that PD affected 6.1 million people worldwide, up from 2.5 million in 1990, and this figure is predicted to more than double by 2040. 4 Moreover, PD is present in approximately 3% of individuals aged 65 and above, with the largest number of cases reported in those over 70 years old.…”