Effect of refeeding on IGFI, IGFII, IGF receptors, FGF2, FGF6, and myostatin mRNA expression in rainbow trout myotomal muscle

Chauvigné, François; Gabillard, Jean-Charles; Weil, Claudine; Rescan, Pierre‐Yves

doi:10.1016/s0016-6480(03)00081-9

Cited by 182 publications

(132 citation statements)

References 32 publications

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“…Data are mean ± SEM (n = 8) Among fasting treatments, the mRNA levels were higher in the F1 group. These findings are in agreement with other studies in which reductions in muscle IGF-1 levels as a result of fasting, and subsequent recovery following 2-4 weeks of refeeding have also been seen in studies with tilapia juveniles Oreochromis mossambicus (Fox et al 2009), rainbow trout Oncorhynchus mykiss fry (Montserrat et al 2007), and rainbow trout adults submitted to 10 weeks of food deprivation and 4-34 days of refeeding (Chauvigne et al 2003).…”

Section: Discussionsupporting

confidence: 92%

Alteration in expression of atrogenes and IGF-1 induced by fasting in Nile tilapia Oreochromis niloticus juveniles

et al. 2017

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The growth rate of farmed fish is an important factor regarding aquaculture success. An understanding of the cellular events that occur in skeletal muscle when fish undergo periods of fasting and refeeding provides information useful in developing alternative feeding strategies for improving muscle growth in commercially cultivated species. To evaluate the effect of 1-3 weeks of fasting and 10 weeks of refeeding in Nile tilapia juveniles, we analyzed the growth performance and changes in muscle cellularity and the expression of the following growth and muscle related genes: MyoD, myogenin, IGF-1, IGF-1 receptor, MuRF-1, atrogin-1 and myostatin. Reduced body mass was observed in all three groups of fasted fish during their time off feed, and 10 weeks of refeeding resulted in partial compensatory growth of body mass. No differences in the frequency of white muscle fiber diameters were observed between fasted and fed control fish treatments. However, changes in gene expression induced by fasting and refeeding were found. IGF-1 receptor, ubiquitin ligases MuRF1 and atrogin-1 expression increased during the 1-3 weeks of fasting, while IGF-1 levels dropped significantly (P \ 0.001) compared to the control treatment. Furthermore, myogenin mRNA level in fish submitted to 3 weeks of fasting was higher in comparison to the control treatment (P \ 0.05). Overall, our results showed that 1-3 weeks of fasting can induce muscle atrophy activation in Nile tilapia juveniles, and 10 weeks of refeeding is enough to induce only partial compensatory growth.

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Section: Discussionsupporting

confidence: 92%

Alteration in expression of atrogenes and IGF-1 induced by fasting in Nile tilapia Oreochromis niloticus juveniles

et al. 2017

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“…Aside from the endocrine effects of Igf1 and possibly Igf2, local autocrine/paracrine dynamics of Igf1 may also contribute to the phase of accelerated growth (Chauvigné et al 2003, Luckenbach et al 2007). In particular, transgenic tilapia overexpressing Ghs were twofold heavier than wild types yet had depressed levels of plasma Igf1 and elevated skeletal muscle igf1 gene expression (Eppler et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, its levels have been correlated to specific growth rate (SGR) in numerous teleosts (Uchida et al 2003, Beckman et al 2004, Vera Cruz et al 2006, and the recent evidence indicates that the presence or absence of a single IGF1 nucleotide polymorphism may determine body size in dogs (Sutter et al 2007). In addition to hepatic binding, GH may also act directly on target tissues such as skeletal muscle to stimulate the production of IGF1, which in turn can act in a paracrine/autocrine fashion to stimulate tissue growth (Chauvigné et al 2003). The potential contribution of locally produced Igf1 to anabolism is further underscored by studies in Gh-transgenic tilapia (Oreochromis niloticus), which showed elevated growth and skeletal igf1 mRNA but reduced plasma Igf1 relative to wild-type controls (Eppler et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Regulation of endocrine and paracrine sources of Igfs and Gh receptor during compensatory growth in hybrid striped bass (Morone chrysops×Morone saxatilis)

Picha

Turano

Tipsmark

et al. 2008

Journal of Endocrinology

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Compensatory growth (CG) is a period of growth acceleration that exceeds normal rates after animals are alleviated of certain growth-stunting conditions. In hybrid striped bass (HSB, Morone chrysops!Morone saxatilis), 3 weeks of complete feed restriction results in a catabolic state that, when relieved, renders a subsequent phase of CG. The catabolic state was characterized by depressed levels of hepatic Type I and II GH receptor (ghr1, ghr2) and igf1 mRNA, along with considerable decreases in plasma Igf1. The state of catabolism also resulted in significant declines in hepatic igf2 mRNA and in circulating 40 kDa Igfbinding protein (Igfbp). Skeletal muscle expression of ghr2 mRNA was significantly increased. Upon realimentation, specific growth rates (SGRs) were significantly higher than sized-matched controls, indicating a period of CG. Hepatic ghr1, ghr2, igf1 and igf2 mRNA levels along with plasma Igf1 and 40 kDa Igfbp increased rapidly during realimentation. Plasma Igf1 and total hepatic igf2 mRNAwere significantly correlated to SGR throughout the study. Skeletal muscle igf1 mRNA also increased tenfold during CG. These data suggest that endocrine and paracrine/autocrine components of the GH-Igf axis, namely igf1, igf2, and ghr1 and ghr2, may be involved in CG responses in HSB, with several of the gene expression variables exceeding normal levels during CG. We also demonstrate that normalization of hepatic mRNA as a function of total liver production, rather than as a fraction of total RNA, may be a more biologically appropriate method of quantifying hepatic gene expression when using real-time PCR.

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“…The fasting/refeeding paradigm has been widely used to investigate the molecular mechanisms underlying the transition from a catabolic to an anabolic state in fish [22][23][24][25]. For instance, in juvenile rainbow trout (Oncorhynchus mykiss) fasted for 10 weeks, refeeding resulted in a 15-fold increase in insulin-like growth factor I (IGF-I) mRNA 12 days following refeeding, and in a much smaller increase in the less abundant insulin-like growth factor II (IGF-II) mRNA [22].…”

Section: Major Specific Aspects Of Fish Growthmentioning

confidence: 99%

“…For instance, in juvenile rainbow trout (Oncorhynchus mykiss) fasted for 10 weeks, refeeding resulted in a 15-fold increase in insulin-like growth factor I (IGF-I) mRNA 12 days following refeeding, and in a much smaller increase in the less abundant insulin-like growth factor II (IGF-II) mRNA [22].…”

Section: Major Specific Aspects Of Fish Growthmentioning

confidence: 99%

Peptide transport and animal growth: the fish paradigm

et al. 2011

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Physiology Opinion piecePeptide transport and animal growth: the fish paradigm Protein digestion products are transported from the intestinal lumen into the enterocyte both in the form of free amino acids (AAs), by a large variety of brush border membrane AA transporters, and in the form of di/tripeptides, by a single brush border membrane transporter known as PEPtide Transporter 1 (PEPT1). Recent data indicate that, at least in teleost fish, PEPT1 plays a significant role in animal growth by operating, at the gastrointestinal level, as part of an integrated response network to food availability that directly supports body weight. Notably, PEPT1 responds to both fasting and refeeding and is involved in a phenomenon known as compensatory growth (a phase of accelerated growth when food levels are restored after a period of growth depression). In particular, PEPT1 expression decreases during fasting and increases during refeeding, which is the opposite of what observed so far in mammals and birds. These findings in teleost fish document, to our knowledge, for the first time in a vertebrate model, a direct correlation between the expression of an intestinal transporter, such as PEPT1, primarily involved in the uptake of dietary protein degradation products and animal growth.Keywords: di/tripeptides; PEPtide Transporter 1; teleost fish; growth; fasting/refeeding INTRODUCTIONThe modern mode of thinking that digested protein is transported from the intestinal lumen into enterocytes and then into the circulation both as amino acids (AAs) and di/tripeptides dates back to the mid-1970s. Today, we know that di/tripeptides are taken up by a single transporter known as PEPtide Transporter 1 (PEPT1). However, some questions remain unanswered. For instance, although PEPT1 knock-out models have been generated [1,2], it is not clear whether the intestinal peptide transporter plays a role in the up-or downregulation of animal growth. Indeed, by deleting the intestinal peptide transporter pept1 (previously known as pep-2) body size is reduced in an invertebrate animal model, such as the nematode Caenorhabditis elegans [1,3], whereas PepT1 null mice grow to normal size, body weight and organ weight [2].In recent years, interest in piscine PEPT1 has grown rapidly [4,5]. This is owing to the recurring observation that fish can efficiently use dietary di/tripeptides to sustain development, growth and metabolism [6][7][8][9][10][11][12][13][14]. MAJOR, SPECIFIC ASPECTS OF FISH GROWTHIn most fish, growth is indeterminate and the majority of absorbed nutrients are invested in accreting muscle tissue [15]. Muscle growth in juvenile fish increases both the size (hypertrophia) and number of muscle fibres (hyperplasia). By contrast, the increase in the number of fibres in mammals and birds is arrested shortly after embryonic development has been completed [16], and further muscle growth is mainly caused by hypertrophy of existing fibres. Skeletal muscle forms 40 -60% of the body mass in most adult fish. In muscle, all of the synthesized prot...

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Effect of refeeding on IGFI, IGFII, IGF receptors, FGF2, FGF6, and myostatin mRNA expression in rainbow trout myotomal muscle

Cited by 182 publications

References 32 publications

Alteration in expression of atrogenes and IGF-1 induced by fasting in Nile tilapia Oreochromis niloticus juveniles

Alteration in expression of atrogenes and IGF-1 induced by fasting in Nile tilapia Oreochromis niloticus juveniles

Regulation of endocrine and paracrine sources of Igfs and Gh receptor during compensatory growth in hybrid striped bass (Morone chrysops×Morone saxatilis)

Peptide transport and animal growth: the fish paradigm

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