Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes

Lalande, Sophie; Hofman, Paul L.; Baldi, James C.

doi:10.1111/j.1748-1716.2010.02081.x

Cited by 31 publications

(31 citation statements)

References 47 publications

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“…Impaired left ventricular diastolic function is commonly observed in diabetic patients [14]. Cardiac MRI at rest showed that the ratio of peak early to late mitral inflow velocity (E/A), end-diastolic volume in left ventricle and stroke volume were lower in diabetic patients than in nondiabetic subjects [26]. Although we did not assess left ventricular function in this study, these reports indicate that diabetic patients have less systolic forward flow during the cardiac cycle than nondiabetic subjects.…”

Section: Discussionmentioning

confidence: 63%

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

et al. 2016

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Section: Discussionmentioning

confidence: 63%

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

et al. 2016

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“…Previous studies in diabetic adults showed that aerobic capacity and left ventricular stroke volume during exercise are associated with diastolic dysfunction in adults (5,6). Adults with asymptomatic type 1 diabetes have reduced exercise capacity and lower stroke volume at peak exercise compared with nondiabetic peers, limitations that are strongly associated with diastolic dysfunction (6,7) and reduced EDV during exercise (5,6). It remains unclear whether diabetic adolescents present similar alterations in left ventricular function.…”

mentioning

confidence: 97%

“…Diastolic dysfunction is characterized by reduced early diastolic relaxation, changes ventricular filling patterns (2,3), increases in left ventricular filling pressure during exercise (4), and decreases resting and exercising end-diastolic volume (EDV) (5). At a more advanced stage, these changes are collectively defined as diabetic cardiomyopathy, which may be a precursor to diastolic heart failure (1).…”

mentioning

confidence: 99%

Diastolic Function Is Reduced in Adolescents With Type 1 Diabetes in Response to Exercise

et al. 2012

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OBJECTIVETo determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration.RESEARCH DESIGN AND METHODSThe study evaluated 53 adolescents with type 1 diabetes and 22 control adolescents. Baseline data included peak exercise capacity and body composition by dual-energy X-ray absorptiometry. Left ventricular functional parameters were obtained at rest and during acute exercise using magnetic resonance imaging.RESULTSCompared with nondiabetic control subjects, adolescents with type 1 diabetes had lower exercise capacity (44.7 ± 09 vs. 48.5 ± 1.4 mL/kg fat-free mass [FFM]/min; P < 0.05). Stroke volume was reduced in the diabetes group at rest (1.86 ± 0.04 vs. 2.05 ± 0.07 mL/kg FFM; P = 0.02) and during acute exercise (1.89 ± 0.04 vs. 2.17 ± 0.06 mL/kg FFM; P = 0.01). Diabetic adolescents also had reduced end-diastolic volume at rest (2.94 ± 0.06 vs. 3.26 ± 0.09 mL/kg FFM; P = 0.01) and during acute exercise (2.78 ± 0.05 vs. 3.09 ± 0.08 mL/kg FFM; P = 0.01). End-systolic volume was lower in the diabetic group at rest (1.08 ± 0.03 vs. 1.21 ± 0.04 mL/kg FFM; P = 0.01) but not during acute exercise. Exercise capacity and resting and exercise stroke volumes were correlated with glycemic control but not with diabetes duration.CONCLUSIONSAdolescents with type 1 diabetes have reduced exercise capacity and display alterations in cardiac function compared with nondiabetic control subjects, associated with reduced stroke volume during exercise.

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“…Lalande et al (6) found that a small group of men with T2DM had shorter diastolic duration and an increased reliance on late diastolic filling that accompanied smaller end-diastolic and stroke volumes. However, resting measurements may be misleading because they do not represent the loading conditions during exercise, when left ventricular pressure gradients increase and left ventricular filling time is reduced (12)(13)(14)(15).…”

mentioning

confidence: 99%

Systolic and Diastolic Abnormalities Reduce the Cardiac Response to Exercise in Adolescents With Type 2 Diabetes

et al. 2014

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OBJECTIVETo better understand the cardiac limitations during exercise in adolescents with type 2 diabetes mellitus (T2DM), we measured left ventricular performance with magnetic resonance imaging (MRI) during exercise in diabetic and nondiabetic adolescents. RESEARCH DESIGN AND METHODSThirteen subjects with T2DM, 27 overweight/obese nondiabetic (ObeseND) subjects, and 19 nondiabetic nonobese control subjects were recruited. Cardiac (left ventricular) MRI scans were performed at rest and during submaximal exercise. RESULTSVO 2 peak indexed to fat-free mass was reduced in T2DM and ObeseND subjects compared with control subjects (P < 0.0001). Indexed cardiac output increased less during exercise and was 20% lower in T2DM subjects due to reduced stroke volume. This was a consequence of reduced ventricular filling with smaller enddiastolic volume, which decreased further during exercise in T2DM subjects, but not in ObeseND or control subjects. End-systolic volume was also smaller in T2DM subjects. These changes were associated with increased resting and exercise diastolic blood pressure, and total peripheral resistance in T2DM subjects. CONCLUSIONSIndependently of obesity, T2DM impairs cardiac function during exercise in adolescents. Diabetes Care 2014;37:143937: -144637: | DOI: 10.233737: /dc13-2031 Exercise is a standard recommendation in the management and prevention of type 2 diabetes mellitus (T2DM) (1,2). Regrettably, people with diabetes often have reduced cardiac reserve (3,4) and a resultant decrease in aerobic capacity (3,5). Adults with T2DM have smaller left ventricular stroke volume (6) and reduced heart rates (3,7) during peak exercise. These factors may present a barrier to exercise participation because recommended "moderate intensity" exercise (2) requires a greater proportion of their aerobic capacity (8).Several authors suggest that reduced early left ventricular diastolic filling (i.e., diastolic dysfunction) is responsible for lower aerobic capacity in people with T2DM,

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Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes

Cited by 31 publications

References 47 publications

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

Diastolic Function Is Reduced in Adolescents With Type 1 Diabetes in Response to Exercise

Systolic and Diastolic Abnormalities Reduce the Cardiac Response to Exercise in Adolescents With Type 2 Diabetes

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