Effect of Red Pepper on Symptoms of Irritable Bowel Syndrome: Preliminary Study

Bortolotti, Mauro; Porta, S.

doi:10.1007/s10620-011-1740-9

Cited by 57 publications

(36 citation statements)

References 66 publications

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“…The following antioxidants have also been examined, but there is insufficient evidence concerning their benefits: Aloe vera [86][87][88][89] Andrographis paniculata [90,91] , bilberry [92,93] , Capsicum [95][96][97] , carnosine [98] , ferrous fumarate [99] , green tea [100] , kiwifruit [101] , mastic gum [102] , N-acetyl cysteine [103] , oxpentifylline [104] , pomegranate [106] , psyllium [107,108] , Pycnogenol [109] , resveratrol (red wine) [110] , superoxide dismutase [11,111] , and tormentil [112] ( Table 1 ).…”

Section: Peppermintmentioning

confidence: 99%

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

2017

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The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions. However, the benefits of these supplements have not been established. The available 80 human trials were rated for levels of confidence and for benefits of the antioxidant supplements. For Crohn's disease, the supplements for which clear benefits occurred in at least 2 studies were allopurinol, Boswellia serrata (frankincense or shallaki), Artemesia species (wormwood), Tripterygium wilfordii (léi gōng téng), and omega-3 fatty acids. Similar beneficial supplements for ulcerative colitis were allopurinol, Matricaria chamomilla (chamomile), Curcuma longa (curcumin in turmeric), and omega-3 fatty acids. There was also a clear benefit for ulcerative colitis in 2 studies where a multiherbal Chinese medicine preparation and an Ayurvedic medicine preparation were used. For irritable bowel syndrome, there was only a marginal benefit of some of the antioxidant supplements. Thus, some antioxidant supplements may be beneficial at certain stages of specific diseases. This is consistent with the current concept that antioxidants act by inhibiting oxidative stress pathways in a tissue- and environment-specific manner and not by simply acting as scavengers.

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Section: Peppermintmentioning

confidence: 99%

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

2017

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“…For example capsaicin, which downregulates its receptor, affects visceral sensitivity 60 . In patients with IBS, chronic exposure to capsaicin resulted in reduction of pain and bloating in those able to tolerate its introduction 61 . A more common approach has been to restrict exposure to food chemicals as there is some evidence that food chemicals can cause symptoms.…”

Section: Bioactive Food Chemicalsmentioning

confidence: 99%

Food Components and Irritable Bowel Syndrome

et al. 2015

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“…At the end of the treatment, chronic chili ingestion significantly increased sensory threshold for the first rectal sensation (median [interquartile range]; 16 [12][13][14][15][16] vs. 8 [8][9][10][11][12][13][14][15][16] (Fig. 3).…”

Section: Effect Of Chronic Chili Ingestion On Rectal Sensation In Resmentioning

confidence: 99%

Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study

Aniwan

Gonlachanvit

2014

J Neurogastroenterol Motil

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Background/AimsWhether, chronic chili ingestion can desensitize transient receptor potential vanilloid type 1 receptors in gastrointestinal (GI) tract leading to decrease GI symptoms and sensation in diarrhea-predominant irritable bowel syndrome (IBS-D) patients has not been well explored. The aim of this study was to determine the effects of 6-week chili treatment on postprandial GI symptoms and rectal sensation in response to balloon distention in IBS-D patients. MethodsSixteen IBS-D patients received placebo or chili capsules before meals 3 times/day for 6 weeks in a randomized, double-blinded, crossover fashion with 4-week washout period. Postprandial GI symptoms were evaluated. All patients underwent a rectal barostat study to evaluate rectal sensory threshold at the end of each treatment. ResultsThe maximum postprandial abdominal burning scores were similar between both treatments at baseline 8 [8-16] mmHg, P < 0.05) however, there was no significant effect on rectal compliance (7.3 ± 1.0 vs. 7.1 ± 1.8 mL/mmHg). Other postprandial GI symptoms did not vary significantly between both treatments at baseline and the end of treatment. ConclusionsIn IBS-D patients, 6-week chili ingestion significantly decreased postprandial abdominal burning and increased the rectal sensory threshold. These findings suggest a desensitization effect of chili ingestion on transient receptor potential vanilloid type 1 receptors in the proximal gut and rectum.

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Effect of Red Pepper on Symptoms of Irritable Bowel Syndrome: Preliminary Study

Cited by 57 publications

References 66 publications

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

Food Components and Irritable Bowel Syndrome

Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study

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