Effect of red betel leaf extract (Piper crocatum) against interleukin-1 beta (IL-1β) levels and thickness of feet oedema in Mus musculus (swiss strain) rheumatoid arthritis model

Savitri, Lisa; Maslikah, Siti Imroatul; Susilowati,

doi:10.1063/5.0002562

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Flavonoids as anti-inflammatory agents are also seen from the side of inhibition of COX and lipoxygenase enzyme activities. Inhibition of COX and lipoxygenase pathways can directly inhibit the biosynthesis of eicosanoids and leukotrienes as end products of the COX and lipoxygenase pathways (Savitri et al, 2020).…”

Section: Cox-2 Expression Testmentioning

confidence: 99%

Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract

Damarwati

Wahid²,

Primasari³

et al. 2022

Media Farmasi

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Dental caries requires operative techniques such as pulp devitalization, but pulp devitalization materials that are often used by dentists have serious adverse effects that need to be considered, such as gingival injury and alveolar bone necrosis. Hence, the aim of the present study was to evaluate and formulation of herbal alternatives to pulp devitalization from a combination of Jatropha curcas (Jatropha curcas L.) and red betel leaf extract (Piper crocatum) in the form of a paste and then conducting physical evaluation tests, Cyclooxygenase-2 (COX-2) tests, and also histopathological picture tests to the sample. The formulation of the pasta sample was carried out by the trituration method. Formulation I (FI) contained 25% of Jatropha resin, 0.25% red betel leaf extract, and 25% Jatropha resin, 0.5% red betel leaf extract for Formulation II (FII). The paste produced was then evaluated for physical properties which consisted of organoleptic, homogeneity, pH, spreadability, adhesion, and in vivo anti-inflammatory effect (animal models). In the COX-2 expression test, FI has a COX-2 expression percentage value of 0.38% and a COX-2 suppression percentage value of 0.62%, while FII has a COX-2 expression percentage value of 0.59% and suppression of COX-2 of 0.41%. The optimal concentration of the paste formulation is the paste with a combination of 25% jatropha latex and 0.25% red betel leaf extract had been shown to have potential as an alternative to pulp devitalization.This is an open access article under the CC-BY-SA license.

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Section: Cox-2 Expression Testmentioning

confidence: 99%

Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract

Damarwati

Wahid²,

Primasari³

et al. 2022

Media Farmasi

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show abstract

“…Sampel yang digunakan pada penelitian ini yaitu daun sirih merah yang berumur setengah tua atau tidak terlalu muda yang dipetik dari daun ke 3-5 dari ujung tanaman (Savitri et al, 2020). Pemetikan daun sirih merah ini dilakukan pada sore hari jam 15.00 WIB.…”

Section: Hasil Dan Pembahasanunclassified

UJI AKTIVITAS EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) TERHADAP BAKTERI Propionibacterium acnes

Rahma

2022

Jumakes

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Tujuan penelitian ini untuk mengetahui aktivitas ekstrak etanol daun sirih merah (Piper crocatum) terhadap bakteri Propionibacterium acnes. Daun sirih merah dipilih karena diduga memiliki kandungan senyawa sebagai agen antibakteri seperti flavonoid, alkaloid,tanin, dan minyak atsiri.Penelitian dilakukan secara eksperimental menggunakan metode non randomized control group design dengan periode prospektif. Ekstrak di maserasi menggunakan pelarut etanol 96% dan diuapkan hingga diperoleh ekstrak kental. Ekstrak dibuat 3 konsentrasi berbeda yaitu 30%, 60%, dan 90%. Kontrol positif berupa klindamisin dan kontrol negatif berupa DMSO. Pengujian aktivitas antibakteri menggunakan metode difusi sumuran terhadap bakteri Propionibacterium acnes dengan mengukur diameter zona hambat pertumbuhan bakteri. Hasil pengujian menunjukkan bahwa rata-rata diameter zona hambat yang terbentuk setiap sampel yaitu pada konsentrasi 30% sebesar 7,40 mm, konsentrasi 60% sebesar 8,90 mm, dan konsentrasi 90% sebesar 11,20 mm. Sedangkan hasil analisis data menggunakan metode Mann-Whitney diperoleh nilai signifikan p<0,05 yang menunjukkan bahwa terdapat perbedaan yang bermakna diantara kelompok-kelompok percobaan. Kesimpulan dari penelitian ini yaitu ekstrak etanol daun sirih merah memiliki aktivitas terhadap bakteri Propionibacterium acnes dengan konsentrasi yang paling efektif yaitu 90%.Kata Kunci: Daun sirih merah (Piper crocatum), Ekstrak Etanol, Difusi Sumuran, Antibakteri, Propionibacterium acnes.

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Effect of red betel leaf extract (Piper crocatum) against interleukin-1 beta (IL-1β) levels and thickness of feet oedema in Mus musculus (swiss strain) rheumatoid arthritis model

Cited by 2 publications

References 10 publications

Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract

Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract

UJI AKTIVITAS EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) TERHADAP BAKTERI Propionibacterium acnes

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