Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs

Effect of basic fibroblast growth factor on root resorption after delayed autotransplantation of tooth in dogs

“…25, 35-39 FGF-2 has been shown to act on a variety of mesenchymal cell types 40 .With regard to delayed-replantation of tooth, topical application of FGF-2 was shown to be effective in prevention of replacement resorption in animal studies. 22,27 The ability of FGF-2 to stimulate variety of undifferentiated cell types in periodontal tissue 21 lead us to test its potential in enhancing healing of 20 damages induced during the process of autotransplantation. In the present study, significantly greater numbers of PCNA positive cells were found in the newly formed connective tissue in the FGF-2 treated group than in the control group.…”

“…21 Studies have 7 shown that application of FGF-2 enhances the healing of periodontal tissue without ankylosis, root resorption, or epithelial downgrowth in experimental alveolar bone defects in beagle dogs 21 and primate models. 21,26 Seshima et al 27 reported that FGF-2 promotes formation of new PDL and prevents ankylosis and root resorption following reimplantation of teeth in dogs. Recently, a large-scale multi-center randomized clinical trial in Japan reported that application of FGF-2 is efficacious in the regeneration of human periodontal tissue.…”

Effects of diode laser irradiation and fibroblast growth factor on periodontal healing of replanted teeth after extended extra‐oral dry time

“…Extended extra-oral dry time will cause extensive damage to the PDL cells leading to a dramatic inflammatory reaction in the connective tissue around the root surface (3,10). Others studies also used radiographic and histological analyses to assess healing after tooth replantation (7,10,24,26,27). Upon replantation of the tooth, the nude cementum will attract osteoclasts, which will start the resorptive process (2,7).…”

“…However, the isolated use of FGF showed, in some of the specimens, a thin and disorganized connective tissue and, when PDL fibers were present, they were not reintegrated to the root surface. HPMC is a hydrophilic polymer able to adhere to water and form a gel layer that serves as an essential carrier for controlling FGF delivery (24). Sae-Lim et al (26) did not achieve favorable results when filling the alveolus with recombinant FGF solution as well as applying it to the root surface prior to tooth replantation.…”

“…Basic fibroblast growth factor (bFGF or FGF-2) is a single-chain polypeptide that induces various biological responses including enhancement of angiogenesis, migration and proliferation of fibroblasts, and is one of the most potent mitogens for periodontal cells (18,19). The use of bFGF in stimulating periodontal healing of delayed replanted teeth has also obtained positive results (24,25). The use of bFGF in stimulating periodontal healing of delayed replanted teeth has also obtained positive results (24,25).…”