Effect of recanalization on clinical outcomes in patients with cerebral venous thrombosis – An ambispective study

Recanalization and outcomes after cerebral venous thrombosis: a systematic review and meta-analysis

“…When anticoagulation details were provided (20 of 23 studies), treatment was initiated with heparin/low molecular weight heparin, then maintenance oral anticoagulation with: vitamin K antagonists (10 of 23 studies, direct oral anticoagulants (DOACs; 2 of 23 studies); oral anticoagulation unspecified (4 of 23 studies, or assigned to either vitamin K antagonists versus DOAC (3 of 23 studies). In the latter group, 1 study was a 1:1 randomized controlled trial [ 10 ], 1 study had 5% of participants receive DOAC [ 22 ], and 1 study had 10% on DOAC by follow-up [ 23 ]. One study clearly stated that all participants were immediately started on a DOAC after diagnosis [ 20 ].…”

“…Overall, 21 studies reported the relationship between recanalization and prognosis with the mRS ( Table 1 ). In total, 18 studies with 735 included patients had data suitable for calculating pooled ORs for no versus any recanalization in relation to functional outcome as per mRS [ 10 , [12] , [13] , [14] , [15] , [16] , [17] , [18] , 20 , 21 , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] ]. An additional study reported data from 508 patients [ 11 ] suitable for pooling with the other studies using inverse variance weighting.…”

“…An additional study reported data from 508 patients [ 11 ] suitable for pooling with the other studies using inverse variance weighting. Overall, 14 studies with 564 included patients in total had data suitable for calculating pooled ORs by degree of recanalization [ [15] , [16] , [17] , [18] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [28] , [29] , [30] ]. When examining the effect sizes related to functional outcome and recanalization, the funnel plot was symmetric on visual inspection, and Egger’s test was not significant ( Figure S2 , Supplementary Material ).…”

“…Eleven studies with 566 patients in total reported rates of CVT recurrence in relation to recanalization status [ 12 , [14] , [15] , [16] , [19] , [20] , [21] , 23 , 25 , 26 , 29 ]. Only 1 study included a definition of recurrence, which was “presence of symptoms suggestive of [CVT] and either extension of the previous thrombus or re-occlusion of the sinuses” [ 23 ]. As compared with any recanalization, no recanalization was associated with an increased odds of recurrence (OR, 8.81; 95% CI, 1.63-47.66; p = 0.01; I 2 , 48%).…”

Cerebral vein thrombosis: from risk factors to recanalization and clinical outcomes. A review

“…В табл. 4 представлены предикторы полной и неполной реканализации [21,34,44,49,[54][55][56][57][58].…”