Effect of Reactive Hyperemia on Carotid-Radial Pulse Wave Velocity in Hypertensive Participants and Direct Comparison With Flow-Mediated Dilation: A Pilot Study

Abstract

hyperemia decreases PWV(1min) in NT but not in HT. DeltaPWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.

Impaired endothelium mediated vascular reactivity in endogenous Cushing's syndrome

“…These vascular responses are accompanied by simultaneous changes in peripheral pulse waveform characterised by a gradual increase in the pulse waveform amplitude and slope which tend to maximise around the time point of peak dilatation of proxi-of RH, had a strong and significant negative correlation with morning fasting cortisol levels in the patient group. PTT/pulse wave velocity changes during the second minute of reactive hyperemia would possibly represent the flow mediated, nitric oxide dependent vasorelaxation of the conduit vessels which has been reported as a marker of endothelial function [32,33]. The results of our correlation analysis are in accordance with findings of Akaza et al [15] who showed a significant negative correlation between percentage changes in brachial artery diameter during flow mediated dilatation and morning cortisol levels in patients of CS.…”

“…This rise in digital pulse waveform amplitude during reactive hyperemia has been shown to be dependent on endothelial nitric oxide synthesis [18]. Vascular tone changes in conduit and resistance vessels during reactive hyperemia are mainly due to myogenic vasorelaxation taking place during the period of arterial occlusion as well as due to the vasorelaxation induced by flow mediated release of NO during the phase of RH [22,32,33].…”

Carotid-radial pulse wave velocity responses following hyperemia in patients with congestive heart failure

“…Several groups have demonstrated PWV to decrease in healthy subjects following hyperemia provoked by release of arterial cuff occlusion. [22][23][24][25][26] PWV responses (D) have been found inversely related to flow mediated dilation (FMD) of the BA assessed by high resolution ultrasound. 25,26 Moreover, blunted PWV responses have been observed in subjects with hypertension, coronary artery disease (CAD) and CHF.…”

“…[22][23][24][25][26] PWV responses (D) have been found inversely related to flow mediated dilation (FMD) of the BA assessed by high resolution ultrasound. 25,26 Moreover, blunted PWV responses have been observed in subjects with hypertension, coronary artery disease (CAD) and CHF. 23,[25][26][27][28][29] Although the presence of CHF was the strongest predictor of a blunted PWV decline, specific factors related to the hyperemic PWV response in the setting of CHF remain unknown.…”

“…25,26 Moreover, blunted PWV responses have been observed in subjects with hypertension, coronary artery disease (CAD) and CHF. 23,[25][26][27][28][29] Although the presence of CHF was the strongest predictor of a blunted PWV decline, specific factors related to the hyperemic PWV response in the setting of CHF remain unknown. Accordingly, the objective of this study was to identify factors associated with PWV responses in the setting of CHF.…”