Effect of rapid normalization of plasma glucose levels on microvascular dysfunction and polyol metabolism in diabetic rats

Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

“…In view of the linkages between increased vascular permeability, capillary basement membrane thickening, and increased polyol metabolism in galactose-fed and in diabetic rats, it is of interest that normalization of vascular permeability in granulation tissue vessels (formed in the diabetic milieu) following infusion of insulin by Osmet pumps implanted intraperitoneaily requires approximately 14 days. 216 The normalization of vascular permeability proceeds at a relatively linear rate over the entire 14-day period despite the fact that plasma glucose levels and granulation tissue polyol levels are virtually normalized by 2 days after initiation of insulin treatment. The time course of normalization of permeability changes in this study and of basement membrane thickening in diabetic humans, and evidence that stabilization and/or reversal of retinal and renal changes requires several months to 2-3 years following improved glycemic control in human diabetics all are consistent with the concept that the normalization and stabilization process requires synthesis and remodeling of vascular structural components (cellular and/or extracellular) in addition to normalization of metabolic imbalances associated with hyperglycemia.…”

Regeneración de las lesiones críticas del nervio periférico con factores de crecimiento: Estudio experimental

“…En el contexto de la regeneración axonal, ciertas moléculas que contiene la lámina basal, en particular la fibronectina, la laminina y el sulfato de heparina promueven la elongación axonal in vitro e in vivo (Sandrock & Matthew, 1987;Giftochristos & David, 1988;Rogers et al, 1988;Tomaselli & Reichardt, 1988;Toyota et al, 1990;Wang et al, 1992;Bryan et al, 1993;Kauppila et al, 1993).…”