Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits

Abstract

Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin induced hepatotoxicity in albino rabbits. Study design: Experimental study Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture, Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity produced by atorvastatin. Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation. Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by histological studies.

Hepatoprotective role of tecomella undulata bark extract in comparison with n- acetylcysteine on acetaminophen induced hepatotoxicity in albino rats.

“…Any derangements in normal metabolic processes can provoke hepatic injury. 16 In our study, Acetaminophen was given to rat model to induce liver damage, and the hepatoprotective potential of Tecomella bark extract was compared with N-Acetylcysteine. Acetaminophen produces N-Acetyl P Benzoquinone Imine (NAPQI) when metabolized in liver.…”