Effect of ranitidine on healing of normal and transfusion-suppressed experimental anastomoses

Apostolidis, Stylianos; Michalopoulos, Antonios; Papadopoulos, V. N.; Paramythiotis, Daniel; Zatagias, A.; Gigis, P.; Harlaftis, N.

doi:10.1007/s10151-004-0126-9

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Ranitidine has been shown to have no effect on experimental anastomotic strength, but it did result in a lower incidence of septic complications in an animal study. We cannot directly compare the results of this study to our conclusions, as hydroxyproline levels were not reported and the bursting pressure was determined in a different manner 9. In our study, famotidine exerted a significant influence on anastomotic strength and decreased the collagen content of anastomoses in rats.…”

Section: Discussioncontrasting

confidence: 57%

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Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats

İnan

Şen

Sürgit

et al. 2009

Clinics

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İnan A, Şen M, Sürgit O, Ergin M, Bozer M. Effects of the histamine h2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics. 2009;64(6):567-70. BACKGROUND:Failure of anastomotic healing is one of the major complications in colorectal surgery. Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats. METHODS: Twenty-eight Sprague-Dawley rats were used in the study. Excision and end-to-end anastomosis was performed in the distal colon of the rat. The Famotidine Group received 2 mg/kg/day famotidine; the Control Group received the same amount of saline. Bursting pressure of anastomoses and hydroxyproline content of perianastomotic tissues were evaluated on the third and seventh days following surgery. RESULTS: Bursting pressures and hydroxyproline contents for the Famotidine Group were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. CONCLUSIONS: According to our findings, famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats.

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Section: Discussioncontrasting

confidence: 57%

“…Histamine H2 receptors accelerate cell proliferation, thereby impacting both lymphocyte and immune system response 8,9…”

Section: Introductionmentioning

confidence: 99%

Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats

İnan

Şen

Sürgit

et al. 2009

Clinics

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“…However, the beneficial effect of pharmacotherapy in patient care could not be approved in clinical settings [3,4] . It is clearly shown that a meticulous surgical technique that does not disturb the essential blood supply is a major factor during the first days of intestinal anastomotic healing [5] .…”

Section: Introductionmentioning

confidence: 99%

Supplementation with High-Dose Ascorbic Acid Improves Intestinal Anastomotic Healing

Çevikel¹,

Tuncyurek²,

Ceylan³

et al. 2007

Eur Surg Res

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Background/Aim: Ascorbic acid modulates tissue healing but the value of ascorbic acid supplementation during anastomotic healing remains unclear. We examined the role of ascorbic acid treatment in experimental intestinal resection. Methods: Male Wistar albino rats (n = 30) were divided into three groups: sham treatment (group 1), and daily ascorbic acid treatment with 100 mg/kg (group 2) or 200 mg/kg (group 3) via the intramuscular route. Following sacrifice on the 7th postoperative day, bursting pressure of the anastomoses was measured. Hydroxyproline assessment and histological analysis were carried out. Results: The bursting pressure values of groups 2 (171.4 ± 4.3 mm Hg) and 3 (196.4 ± 2.2 mm Hg) were higher than that of group 1 (139.1 ± 4.1 mm Hg; p < 0.05). In addition, the hydroxyproline level of group 3 (249.2 ± 25.1 µg/mg) was higher than that of groups 1 (157.9 ± 14.9 µg/mg) and 2 (187.9 ± 14.8 µg/mg; p < 0.05). The histopathological scores indicated improved healing in groups 3 (6.0 ± 0.2) and 2 (4.4 ± 0.4), compared to group 1 (2.7 ± 0.3; p < 0.05). Conclusion: In the present study, supraphysiologic doses of ascorbic acid improved anastomotic healing. Therefore, vitamin C supplementation poses as a beneficial treatment in the context of collagen accumulation, inflammatory response, and anastomotic strength. However, the clinical value of high-dose ascorbic acid supplementation in the clinical setting is yet to be established.

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“…Επίσης, έχει δοκιμασθεί η προστατευτική επίδραση στις αναστομώσεις διαφόρων παραγόντων και ουσιών, όπως ομοιάζων με ινσουλίνη αυξητικός παράγοντας Ι -insulin-like growth factor I (122-126), κόλλα ινικής -fibrin glue (127)(128)(129), ερυθροποιητίνη (130), πρώιμη διεντερική σίτιση (131), simvastatin (132), gentamicin (133), silbenafil (134), iloprost (135,136), pentoxifylline (137), οκτρεοτίδη (138), καθώς και celecoxib (32,139). Εκτός των παραπάνω και άλλες ουσίες έχουν μελετηθεί, όπως azathioprine (140), paclitaxel (141), στεροειδή (142), ρανιτιδίνη (143), mycophenolate mofetic (144), καθώς και η υπερθερμική ενδοπεριτοναϊκή έγχυση χημειοθεραπείας -IPEC (145). Ακόμα, έχει μελετηθεί η επίδραση της μετάγγισης αίματος (146), καθώς και του πνευμοπεριτοναίου (147).…”

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Η επίδραση της bevacizumab στην επούλωση των αναστομώσεων του παχέος εντέρου

Παυλίδης¹

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Effect of ranitidine on healing of normal and transfusion-suppressed experimental anastomoses

Abstract: These data indicate that ranitidine has no influence in anastomotic bursting pressure, but has a lower incidence of septic complications.

Cited by 7 publications

References 5 publications

Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats

Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats

Supplementation with High-Dose Ascorbic Acid Improves Intestinal Anastomotic Healing

Η επίδραση της bevacizumab στην επούλωση των αναστομώσεων του παχέος εντέρου

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