Effect of Ramadan Fasting on the Ability of Serum, PBMC and Macrophages from Healthy Subjects to Kill M. Tuberculosis

Lahdimawan, Ardik; Handono, Kusworini; Indra, M. Rasjad; Prawiro, Sumarno Reto

doi:10.9790/3008-09132429

Cited by 10 publications

(10 citation statements)

References 38 publications

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“…Ramadan fasting was shown to enhance the killing ability of PBMC and macrophages against M. tuberculosis when compared to serum activity. There was no alteration on the serum levels of complement C3, iNOS, or SOD during Ramadan fasting ( 15 ). Furthermore, Ramadan fasting in a sample of 30 male patients was shown to enhance macrophagic killing abilities against tuberculosis ( 15 ).…”

Section: Immunity Changes In Healthy Individualsmentioning

confidence: 97%

Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review

et al. 2017

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Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact on body systems in different manners. The influence of Ramadan fasting on immune system regulation remains elusive; however, immune system changes, such as the modulation of body response to various infectious, stressful, and other harmful events, are of great interest during fasting. In this paper, we performed an extensive systematic literature review of different scholarly databases (ISI/Web of Science, Scopus, PubMed,/MEDLINE, Google Scholar, Directory of Open Access Journals, EbscoHOST, Scirus, Science Direct, the Cochrane Library, and ProQuest), using the following key words: “fasting,” “Ramadan,” “Islam,” and “immunity.” Conclusions drawn from these findings included: (1) Ramadan fasting has been shown to only mildly influence the immune system and the alterations induced are transient, returning to basal pre-Ramadan status shortly afterward. (2) Ramadan fasting during the second trimester of pregnancy was shown to be safe and did not result in negative fetal outcomes, or maternal oxidative status alterations. (3) In cardiac patients, Ramadan fasting can have beneficial effects including lipid profile improvement and alleviation of oxidative stress. (4) In asthmatic patients as well as in patients with human immunodeficiency virus/acquired immunodeficiency syndrome and autoimmune disorders, fasting was safe. (5) In psychiatric patients, such as those suffering from schizophrenia, fasting could increase immunologic markers. (6) Fasting Muslim athletes who maintain intensive training schedule during Ramadan showed fluctuations of immunologic markers.

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Section: Immunity Changes In Healthy Individualsmentioning

confidence: 97%

Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review

et al. 2017

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“…A study tested the effect of Ramadan fasting on the body's ability to fight the pathogenic bacterial infection by Mycobacterium tuberculosis , which causes tuberculosis, of thirty fasting volunteers. [ 33 ] It demonstrated that fasting during Ramadan was associated with a reduction in pathogenicity of the bacteria by increasing the numbers of macrophages. The study also showed the ability of fasting to increase the secretion of INF-γ, which is known to stimulate the anti-microbial immune mechanisms against multiple bacterial and viral infections, as discussed above.…”

Section: Resultsmentioning

confidence: 99%

Ramadan intermittent fasting and immunity: An important topic in the era of COVID-19

Faris¹,

Salem²,

Jahrami³

et al. 2020

Ann Thorac Med

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WITH the growing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS)-related coronavirus (SARS-CoV-2) infection, a parallel growing interest arose concerning potential preventive and adjunct therapies, dietary and lifestyle modifications, and remedies that may boost the immunity against SARS-CoV-2 infection. Furthermore, as Ramadan intermittent religious fasting that is practiced by about one and a half billion Muslims throughout the globe is coincide this year with COVID-19 pandemic, a growing debate rose concerning the expected impact of fasting during Ramadan month and the associated dietary and lifestyle behaviors on the body's immunity against the pandemic infection. Published literature was searched to find out how intermittent fasting (IF) and its model of Ramadan affect the various aspects related to the body's immunity against microbial infections. IF was found to impact immunity by changing different related elements, including oxidative stress and inflammation, metabolism, body weight, and body composition. Dietary and lifestyle modifications during Ramadan month and their impact on immunity, such as water intake and hydration status, sleep duration and timing, caloric intake and mealtime, and social and spirtual activities, were addressed. Further research is warranted to figure out how IF during ramadan affects immunity against SARS-CoV-2 infection.

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“… 23 The effects of fasting on oxidative stress have investigated by different groups by mean of assessing different markers of oxidative stress. Lahdimawan et al 24 reported that Ramadan altered classically activated macrophage regulation and signaling, reducing macrophage oxidative stress. In addition, Ibrahim and colleagues measured MDA, glutathione, glutathione peroxidase and catalase levels in individuals during Ramadan.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases

Asadi

Abolfathi

Badalzadeh

et al. 2015

J Cardiovasc Thorac Res

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Introduction: Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively. Moreover, diet is one of the main factors that can modify cardiovascular risks. Therefore, this study aimed to investigate the effects of Ramadan fasting on SAA and protein carbonyl group levels in patients with CVDs. Methods: Twenty-one patients (21 male; mean age 52±9 years old) with CVDs (coronary artery disease, cerebrovascular, or peripheral arterial diseases) were participated in this study. Biochemical parameters were measured in patients 2 days before and 2 days after Ramadan fasting. SAA levels were assessed using enzyme-linked immunosorbent assay and Cayman’s protein carbonyl colorimetric assay was provided for measuring protein carbonyl groups. Results: According to the findings of the study, post-Ramadan levels of inflammatory biomarker, SAA was decreased significantly in patients with CVDs in comparison with the baseline before-fasting values (16.84±8.20 vs. 24.40±6.72 μg/ml, P = 0.021). In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039). Conclusion: Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers. However, to get a clear conclusion with more results, further investigation is warranted.

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Effect of Ramadan Fasting on the Ability of Serum, PBMC and Macrophages from Healthy Subjects to Kill M. Tuberculosis

Cited by 10 publications

References 38 publications

Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review

Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review

Ramadan intermittent fasting and immunity: An important topic in the era of COVID-19

Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases

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