Effect of Radix isatidis polysaccharide on alleviating insulin resistance in type 2 diabetes mellitus cells and rats

Li, Jiping; Yang, Yunhu; Zhang, Wenyou; Jiang, Zhen; Hu, Tianjiao; Feng, Yi-ting; Liu, Mo-xiang

doi:10.1111/jphp.13023

Cited by 26 publications

(10 citation statements)

References 28 publications

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“…21–24 Ye Yuan et al found that Radix isatidis polysaccharides reduced insulin resistance and improved glucose metabolism, lipid metabolism and oxidative stress. 25,26…”

Section: Discussionmentioning

confidence: 99%

“…[21][22][23][24] Ye Yuan et al found that Radix isatidis polysaccharides reduced insulin resistance and improved glucose metabolism, lipid metabolism and oxidative stress. 25,26 In previous studies, EP showed antiviral activity at oral doses of 88 mg kg −1 d −1 and 176 mg kg −1 d −1 . 27 Xiaowei Huo et al used 125 mg kg −1 , 250 mg kg −1 and 500 mg kg −1 aqueous extracts from the seeds of O. violaceus (the main component of EP), orally administered to mice to investigate their hepatoprotective effects.…”

Section: Food and Function Papermentioning

confidence: 95%

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Epigoitrin alleviates lipid and glucose metabolic disorders induced by a high-fat diet

Xiao

et al. 2022

Food Funct.

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“…21–24 Ye Yuan et al found that Radix isatidis polysaccharides reduced insulin resistance and improved glucose metabolism, lipid metabolism and oxidative stress. 25,26…”

Section: Discussionmentioning

confidence: 99%

Section: Food and Function Papermentioning

confidence: 95%

Epigoitrin alleviates lipid and glucose metabolic disorders induced by a high-fat diet

Xiao

et al. 2022

Food Funct.

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“…and insulin (10 U/Kg, IP) as comparison standards. The safety evaluation was based on biochemical, hematological, and histopathological changes (Li et al, 2019). At the end of administration for the four weeks, rats were weighted, after fasting for 12 hr, and then, the blood samples were withdrawn from the retro-orbital plexus using heparinized micro-capillaries (Optilab, Berlin, Germany) under anesthesia (thiopental sodium 50 mg/kg, IP) (Gazdhar et al, 2013).…”

Section: Safety and Efficacy Evaluationmentioning

confidence: 99%

Evaluation of Antidiabetic and Anti-Obesity Potential and Safety of a Polyherbal Remedy

Ahmed

2022

Al-Azhar Journal of Pharmaceutical Sciences

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Objective: To evaluate the antidiabetic and anti-obesity potentials and the safety of a polyherbal remedy. Method: A mixture of polyherbal remedy containing Gymnema sylvestre, Garcinia cambogia, Cleome droserifolia, and Nigella sativa (100 or 200 mg/Kg, p.o.) was subjected to qualitative chemical identification for marker compounds on individual plant extracts using Q-TOF-LC-MS. In addition, the antidiabetic and antiobesity potential were evaluated in streptozotocin-induced diabetic rats using metformin (100 mg/Kg, p.o.) and insulin (10 U/Kg, IP) as standards. The evaluation based on fasting blood glucose level (FBG), insulin level, and change in body weight gain of different treatment groups. Furthermore, the safety profile was assessed by the measurement of certain biochemical, hematological, and histopathological parameters. Results: A total of thirteen marker compounds, (Gymnemoside ND1, Myricetin, Hydroxycitric acid lactone, Garcinol, Garcimangosone D, 5,3`-Dihydroxy-3,6,7,4`,5`pentamethoxyflavone, 5-Hydroxy-3,6,7,3`,4`,5`-hexamethoxyflavone, Magnoflorine, Kaempferol glycoside, Sapindoside B, Alpha-hedrin, Tauroside H2, and Thymoquinone) were identified in the four plant extracts individually. The administration of polyherbal remedy extract (100 or 200 mg/Kg, p.o.)-, metformin-, and insulin-treated diabetic rats resulted in a significant decrease in the FBG by 62, 67, 44 and 73 % respectively, and significant increase in insulin level by 2161, 3433, 2400 and 5658 %, respectively, as compared to vehicle-treated control. Regarding the body weight change, polyherbal remedy extract (100 or 200 mg/Kg, p.o.)-, metformin-, and insulin-treated animals demonstrated a significant decrease by 45, 54, 72 and 65%, respectively, as compared to their initial weight. The results of polyherbal remedy (100 or 200 mg/Kg, p.o.)-treated groups showed a dose-independent potency between that obtained from insulin-and metformin-treated groups. Concerning the safety profile; treatment with remedy extracts markedly improved the streptozotocin-induced alteration in the hepatic biochemical, and hematological indices (liver enzymes, total protein, albumin, TC, TG, HDL, LDL, RBCs count, WBCs count, Hb concentration and platelet count) besides preservation of the normal histopathological features of liver, kidney, and pancreas. Conclusion: The polyherbal remedy can be used as an effective and safe treatment of obesity, diabetes, and its complications.

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“…Hyperglycemia not only affects the transduction of apoptotic signals in islet cells but also damages tissues and organs [21]. As one of the major metabolic organs, the liver is the main organ damaged by diabetes.…”

Section: Effects Of Pagr On Histopathological Changes In Livermentioning

confidence: 99%

Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus

et al. 2019

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Rheum palmatum L. is a traditional Chinese medicine with various pharmacological properties, including anti-inflammatory, antibacterial, and detoxification effects. In this study, the mechanism of the hypoglycemic effect of purified anthraquinone-Glycoside from Rheum palmatum L. (PAGR) in streptozotocin (STZ) and high-fat diet induced type 2 diabetes mellitus (T2DM) in rats was investigated. The rats were randomly divided into normal (NC), T2DM, metformin (Met), low, middle (Mid), and high (Hig) does of PAGR groups. After six weeks of continuous administration of PAGR, the serum indices and tissue protein expression were determined, and the pathological changes in liver, kidney, and pancreas tissues were observed. The results showed that compared with the type 2 diabetes mellitus group, the fasting blood glucose (FBG), total cholesterol (TC), and triglyceride (TG) levels in the serum of rats in the PAGR treatment groups were significantly decreased, while superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) levels were noticeably increased. The expression of Fas ligand (FasL), cytochrome C (Cyt-c), and caspase-3 in pancreatic tissue was obviously decreased, and the pathological damage to the liver, kidney, and pancreas was improved. These indicate that PAGR can reduce oxidative stress in rats with diabetes mellitus by improving blood lipid metabolism and enhancing their antioxidant capacity, thereby regulating the mitochondrial apoptotic pathway to inhibitβ-cell apoptosis and improve β-cell function. Furthermore, it can regulate Fas/FasL-mediated apoptosis signaling pathway to inhibit β-cell apoptosis, thereby lowering blood glucose levels and improving T2DM.

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Effect of Radix isatidis polysaccharide on alleviating insulin resistance in type 2 diabetes mellitus cells and rats

Cited by 26 publications

References 28 publications

Epigoitrin alleviates lipid and glucose metabolic disorders induced by a high-fat diet

Epigoitrin alleviates lipid and glucose metabolic disorders induced by a high-fat diet

Evaluation of Antidiabetic and Anti-Obesity Potential and Safety of a Polyherbal Remedy

Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus

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