Effect of Radiotherapy on Whole Saliva Flow

Shannon, Ira L.; Starcke, Edgar N.; Wescott, William B.

doi:10.1177/00220345770560062201

Cited by 69 publications

(20 citation statements)

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“…Radiotherapy at these levels results in a permanent and profound xerostomia to the extent that in many patients it is virtually impossible to collect a saliva sample [Dreizen et al, 1977b;Shannon et al, 1977). Pa tients' ages ranged from 16 to 77 years; all had a minimum of 12 natural teeth and had completed their course of radiotherapy from 1 to 13 years previously.…”

Section: Methodsmentioning

confidence: 99%

Dental Caries and Streptococcus mutans Prevalence in Cancer Patients with Irradiation-Induced Xerostomia: 1–13 Years after Radiotherapy

Keene¹,

Daly²,

Brown³

et al. 1981

Caries Res

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In this cross-sectional study, 9 of 34 irradiated patients and 4 of 5 preradiation patients had one or more carious lesions at the time of examination. The magnitude of Streptococcus mutans infection was determined from multiple samples of dental plaque taken from different anatomic sites. S. mutans were detected in 82% of the irradiated patients and 100 % of the preradiotherapy patients. Although S. mutans were widely distributed throughout the dentition of both groups, the mean proportion of 5. mutans relative to the total streptococci in interproximal samples was significantly higher in the irradiated patients. In the irradiated group without current caries, S. mutans prevalence was inversely related to the number of elapsed years postradiotherapy.

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Section: Methodsmentioning

confidence: 99%

Dental Caries and Streptococcus mutans Prevalence in Cancer Patients with Irradiation-Induced Xerostomia: 1–13 Years after Radiotherapy

Keene¹,

Daly²,

Brown³

et al. 1981

Caries Res

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“…The reduction in salivary flow results in a loss of the protective properties of saliva, a decrease of the pH of saliva and a quantita tive and qualitative shift in oral microfiora. This shift in microfiora is accompanied by a change in the pat tern of food consumption to frequent, nondetergent, high-carbohydrate meals [Del Regato, 1939;Frank et al, 1965;Brown et al, 1975Brown et al, , 1976Shannon et al, 1977Shannon et al, , 1978Cowman et al, 1983].…”

mentioning

confidence: 99%

The Effect of X-Ray Irradiation on the Demineralization of Bovine Dental Enamel

et al. 1988

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In this study the effect of X-ray irradiation on demineralization of bovine dental enamel in vitro was investigated. Enamel specimens were irradiated with 72 Gy and subsequently demineralized (140 h) under reproducible constant composition conditions at pH = 5 in the presence of methylhydroxydiphosphonate (MHDP). Microhardness measurements after demineralization without MHDP showed significant differences (p < 0.001) between irradiated and nonirradiated enamel specimens; no significant differences were found in the presence of MHDP. Quantitative microradiography showed that both mineral loss and lesion depth were significantly lower (p < 0.001) for the irradiated enamel specimens compared with the nonirradiated ones. Surface layer formation was observed in irradiated enamel demineralized in a solution without MHDP. It was shown that X-ray irradiation decreased the enamel acid solubility in vitro.

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“…As a result, patients' quality of life is compromised as they experience changes in speech and taste. The oral dryness also predisposes the patients to fissures, ulcers, dental caries, infection, and even in worst cases, osteoradionecrosis [41][42][43][44]. Thus, IMRT has the potential to reduce the dose to the salivary glands while simultaneously delivering a high dose to the tumor target.…”

Section: Unique Anatomical Challenges In the Treatment Of Nasopharyngmentioning

confidence: 99%