Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma <i>in situ</i>: a meta-analysis

Huang, Xuan; Chen, You; Chen, Wen Jun; Zhang, Xi; Wu, Cong; Zhang, Chao Ying; Sun, Shuang; Wu, Jian

doi:10.18632/oncotarget.15998

Cited by 7 publications

(4 citation statements)

References 40 publications

(56 reference statements)

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“…All the studies differed conceptually including not only elderly patients but also different tumor sizes or systemic therapies. In summary, no significant differences have been shown regarding OS but some decreases in in-breast recurrences after RT [27][28][29] as recent meta-analyses confirmed [30,31]. Interestingly, there is also some evidence that effects of RT also depend on histopathologic subtypes since RT did not improve OS in patients with invasive lobular or uncommon invasive breast cancer types [32].…”

Section: Plos Onementioning

confidence: 98%

Effect of adjuvant radiotherapy in elderly patients with breast cancer

et al. 2020

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Background Radiotherapy (RT) is of critical importance in the locoregional management of early breast cancer. Although RT is routinely used following breast conserving surgery (BCS), patients may occasionally be effectively treated with BCS alone. Currently, the selection of patients undergoing BCS who do not need breast irradiation is under investigation. With the advancement of personalized medicine, there is an increasing interest in reduction of aggressive treatments especially in older women. The primary objective of this study was to identify elderly patients who may forego breast irradiation after BCS without measurable consequences on local tumor growth and survival. Methods We analyzed 2384 early breast cancer patients aged 70 and older who were treated in 17 German certified breast cancer centers between 2001 and 2009. We compared RT versus no RT after guideline adherent (GA) BCS. The outcomes studied were breast cancer recurrence (RFS) and breast cancer-specific survival (BCSS). Low-risk patients were defined by luminal A, tumor size T1 or T2 and node-negative whereas higher-risk patients were defined by patients with G3 or T3/T4 or node-positive or other than Luminal A tumors. To test if there is a difference between two or more survival curves, we used the G p family of tests of Harrington and Fleming. Results The median age was 77 yrs (mean 77.6±5.6 y) and the median observation time 46 mths (mean 48.9±24.8 mths). 950 (39.8%) patients were low-risk and 1434 (60.2%) were higherrisk. 1298 (54.4%) patients received GA BCS of which 85.0% (1103) received GA-RT and only 15% (195) did not. For low-risk patients with GA-BCS there were no significant differences in RFS (log rank p = 0.651) and in BCSS (p = 0.573) stratified by GA-RT. 5 years RFS in both groups were > 97%. For higher-risk patients with GA-BCS we found a significant difference (p<0.001) in RFS and tumor-associated OS stratified by GA-RT. The results remain

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Section: Plos Onementioning

confidence: 98%

Effect of adjuvant radiotherapy in elderly patients with breast cancer

et al. 2020

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“…Of the 10 studies, all had surgery, 5 had radiotherapy [ 47 , 49 , 51 , 52 , 53 ], 5 had chemotherapy [ 46 , 49 , 52 , 53 , 54 ], and 2 had hormone therapy [ 47 , 49 ]. Adjuvant radiotherapy is the standard treatment following breast conserving surgery in early breast cancer [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Respiratory Physiotherapy Intervention Strategies in the Sequelae of Breast Cancer Treatment: A Systematic Review

Vinolo-Gil

Martín-Valero

Martín-Vega

et al. 2022

IJERPH

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Breast cancer treatments can trigger respiratory sequelae. Respiratory physiotherapy helps to eliminate or mitigate the sequelae by optimizing respiratory function. This systematic review aims to synthesize the scientific evidence and assess its quality regarding the use of respiratory physiotherapy in the sequelae of breast cancer. The Cochrane Library, Physiotherapy Evidence Database, PubMed, Web of Science, Scientific Electronic Library Online, Cumulative Index of Nursing and Allied Literature Complete, and Scopus were searched. Study quality was determined using the PEDro scale, STROBE Statement, and Single-Case Experimental Design Scale. Ten studies, six clinical trials, one case study, and three observational studies were selected. The mean methodological quality of the clinical trials was 5.6, that of the case study was 7, and that of the observational studies was 56%. Respiratory physiotherapy has been observed to improve respiratory capacity, lung function, respiratory muscle strength, effort tolerance, dyspnea, fatigue, thoracic mobility, upper limb volume, sleep quality and quality of life, as well as sensitivity to adverse physiological reactions, nausea, vomiting, and anxiety. However, it is not effective for vasomotor symptoms. More clinical trials are needed. These studies should homogenize the techniques used, as well as improve their methodological quality.

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“…A recent meta-analysis also indicated that radiotherapy could slightly reduce the risk of local relapse in older patients if breast cancer was diagnosed early. However, reduced local relapse cannot translate into significant survival benefits (5). These previous studies have not provided uniform, positive results regarding radiotherapy for breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Developing a radiosensitivity gene signature for Caucasian patients with breast cancer

Jiang

Jian

et al. 2018

Oncol Rep

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Adjuvant radiotherapy is an important clinical treatment option for patients with breast cancer. However, for Caucasian patients, the clinical benefit of adjuvant radiotherapy can differ from African‑American patients with respect to the overall survival. The goal of the current study was to develop a gene signature and to pre‑identify patients likely to benefit from radiotherapy. Using publicly available breast cancer data from The Cancer Genome Atlas, a new cross‑validation procedure was proposed for developing a gene signature and predicting radiosensitive patients. The results demonstrated that the predicted radiosensitive patients who received radiotherapy exhibited a significantly better survival, while the effect of radiotherapy was not significant for predicted non‑radiosensitive patients. Further hierarchical cluster analysis revealed that the predicted sensitivity for each patient corresponded closely to the results of the cluster analysis. Collectively, the findings of the current study demonstrated that a radiosensitive molecular signature can be used to identify radiosensitive Caucasian patients with breast cancer.

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Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis

Cited by 7 publications

References 40 publications

Effect of adjuvant radiotherapy in elderly patients with breast cancer

Effect of adjuvant radiotherapy in elderly patients with breast cancer

Respiratory Physiotherapy Intervention Strategies in the Sequelae of Breast Cancer Treatment: A Systematic Review

Developing a radiosensitivity gene signature for Caucasian patients with breast cancer

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