Effect of Radiation Therapy on Intraocular Pressure in Patients with Graves’ Orbitopathy

Russell, David; Dutton, Jonathan J.; Baca, Rosalinda

doi:10.3109/01676830.2013.788663

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…4,8,9,12,19,[36][37][38][39][40][41][42] Other TED treatment modalities which reduce IOP are summarized in Table 3. This includes strabismus surgery 4,20,37 (to correct ocular alignment and relieve tension of fibrotic muscles), orbital radiation therapy, 4,43 pulsed intravenous methylprednisolone therapy, 37,40 topical IOPlowering agents, 44,45 and botulinum A toxin injections. 32 Upon assessment of current literature, measurements of IOP were highly variable in timing-if timepoints were at all stated-and different measurement techniques were reported.…”

Section: Iop Reduction In the Treatment Of Thyroid Eye Diseasementioning

confidence: 99%

Intraocular Pressure and Glaucoma in Thyroid Eye Disease

Betzler

Sundar²

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Current literature lacks a summary of knowledge on intraocular pressure (IOP) elevation and glaucoma in thyroid eye disease (TED). This review aims to augment existing literature by providing such a summary. It qualitatively evaluates current knowledge on the pathogenesis, prevalence, and management of concomitant ocular hypertension or glaucoma in TED patients.Methods: In this narrative review, relevant publications were identified through a computerized database search. Search results were screened for relevance. Correspondence, Editorials, and Letters to the Editors were excluded. References cited within the identified articles were used to further augment the search. Information extracted for qualitative analysis included epidemiologic data, methods of IOP assessment, management protocols, and response to treatment.Results: Studies in current literature are relatively heterogenous, differing in country of origin, TED cohort sizes, and IOP measurement techniques. Further studies are required to elucidate the true epidemiologic relationship between TED and ocular hypertension or glaucoma. Proposed models of IOP elevation include elevation of episcleral venous pressure, mucopolysaccharide deposition within the trabecular meshwork, restrictive myopathy, steroid-induced glaucoma, and secondary glaucoma. IOP-reducing effects of TED treatment options are discussed.Conclusions: While raised IOP in TED is a common phenomenon, the diagnosis of glaucoma in TED requires a high index of suspicion before any intervention.

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Section: Iop Reduction In the Treatment Of Thyroid Eye Diseasementioning

confidence: 99%

Intraocular Pressure and Glaucoma in Thyroid Eye Disease

Betzler

Sundar²

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

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The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid optic neuropathy

2017

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Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe. However, risks still exist in some cases. The possible effects of radiotherapy on TAO, especially complicated with DON, are reviewed. The effects of radiotherapy on DON are not completely known, and evidence from standardized, prospective, and multicenter clinical trials is still lacking.

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Effect of Radiation Therapy on Intraocular Pressure in Patients with Graves’ Orbitopathy

Cited by 2 publications

References 14 publications

Intraocular Pressure and Glaucoma in Thyroid Eye Disease

Intraocular Pressure and Glaucoma in Thyroid Eye Disease

The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid optic neuropathy

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