Effect of radiation hygienization of honey on its health protective properties

Saxena, Sudhanshu; Gautam, Satyendra; Sharma, Arun

doi:10.1016/j.fbio.2014.10.002

Cited by 5 publications

(6 citation statements)

References 41 publications

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“…The antimutagenicity of honey was found to be due to the suppression of error-prone repair pathway (as manifested by SOS response) in E. coli. Besides, honey also displayed strong antiproliferative property against different cancer cell lines (myeloid leukemia, breast and lung cancer) but did not affect normal cell line (Int-407, intestinal epithelial cell) indicating its differential and selective cytotoxicity [53]. The findings explained the mechanism of possible therapeutic and prophylactic action of honey against neoplastic changes caused by environmental mutagens and carcinogens.…”

Section: Honeymentioning

confidence: 80%

“…In the case of many foods such as different cultivars of apple, honey, and various vegetables, the extracted or purified bio-actives did not show good correlation between the antioxidant and antimutagenic activities [20,21,[50][51][52][53][54][55]. However, some antimutagenic compounds which are not potent antioxidants on their own but can be converted into molecules that display good antioxidant activity as reported in case of several amino acid conjugates of curcumin demonstrated very high antimutagenic activity against NaN 3 and methyl methanesulfonate (MMS) in Ames test [56].…”

Section: Fruits and Vegetables As Dietary Sources Of Antimutagensmentioning

confidence: 99%

“…This assay is advantageous due to its simplicity in deployment, the ability to provide a wide spectrum of forward mutations and low level of spontaneous mutations (approximately 1/10 8 cells) ( Figure 1). It has been extensively used recently to screen the antimutagenic potential of different foods particularly fruits, vegetables and other allied food products at Food Technology Division, Bhabha Atomic Research Centre, Mumbai, India (Figure 2) [20,[50][51][52][53][54][55][75][76][77][78][79]. The assay is better for scoring antimutagenicity over mutagenicity.…”

Section: Rpob-rifampicin Resistance Assaymentioning

confidence: 99%

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Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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Section: Honeymentioning

confidence: 80%

Section: Fruits and Vegetables As Dietary Sources Of Antimutagensmentioning

confidence: 99%

Section: Rpob-rifampicin Resistance Assaymentioning

confidence: 99%

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Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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“…The selectivity of TH was evident from the increased expression of damaged DNA proteins in MCF-10A cells 53 . Honey's radiation hygienization property in relation to anti-cancer, DNA protective and antimutagenicity effect was recorded by Saxena et al 54 Honey displayed strong anti-proliferative property against breast cancer cell lines devoid of normal cell line (Int-407, intestinal epithelial cell) indicating its differential and selective cytotoxicity. The study demonstrated that honey provides safety during radiation treatment as well as maintaining its nutraceutical value 54 .…”

Section: Honey and Breast Cancermentioning

confidence: 99%

“…Honey's radiation hygienization property in relation to anti-cancer, DNA protective and antimutagenicity effect was recorded by Saxena et al 54 Honey displayed strong anti-proliferative property against breast cancer cell lines devoid of normal cell line (Int-407, intestinal epithelial cell) indicating its differential and selective cytotoxicity. The study demonstrated that honey provides safety during radiation treatment as well as maintaining its nutraceutical value 54 . Kadir et al 55 performed in vivo experiments to evaluate the effect of Malaysian jungle TH on the growth of breast cancer in rats.…”

Section: Honey and Breast Cancermentioning

confidence: 99%

An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer

et al. 2017

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Diet plays a crucial role in cancer advancement as well as prevention. Breast cancer is the second leading cause of cancer death among women. Recent research links breast cancer with diet and some evidence for the preventive effect of diet against breast cancer was also documented. The growth of cancer cells is influenced by natural sweetener honey and its multitude of phenolic phytochemical components. Honey has been used medicinally by ancient Greeks and Egyptians and also traditionally exploited in Ayurveda and Chinese medicine. In this paper, the anti-cancer properties of honey and its phytochemical's action against breast cancer have been summarized. They result in apoptosis by enhancing reactive oxygen species level, activating mitochondrial pathway, initiation of pro-apoptotic and anti-apoptotic proteins, induction of p53 pathway that finally cause DNA fragmentation. However, there is a necessity for more proteomic and genetic-based experiments to understand its molecular mechanism to promote honey and its phenolic markers as plausible candidates for breast cancer treatment. Further, there is a need for quality check of honey available in the market, which warrants significant investigation by researchers in the food industry to ensure their attributes.

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