Effect of Rabdosia Rubescens Total Flavonoids on Cerebral Ischemic Reperfusion Model Mice

Abstract

Abstract. Objective: To study the protective effects of Rabdosia rubescens total flavonoids (RRTF) on the cerebral ischemia reperfusion model(CIRM) of mice. Methods: By blocking bilateral carotid artery blood flow, the mice model of CIRM were established. Before surgery, medicines were given once a day for 7 successive days. The model was constructed after one hour of the last administration, 24h reperfusion after surgery. Measuring LD, LDH and ATP enzyme of mouse brain tissue, and observing morphological changes of brain tissue. Results: Each dose group of RRTF can significantly lower mortality, reduce the content of LD, ease brain tissue damage while can obviously improve the vitality of LDH, enhance the enzyme activity in mice with cerebral ischemia reperfusion injury, such as Na + -K + -ATPase, Mg 2+ -ATPase, Ca 2+ -ATPase. Conclusions: Indicators among each dose of the Rabdosia rubescens flavonoids on cerebral ischemia reperfusion model have better improvement, large doses is the best.