Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats

Abstract

Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

“…The administration of hesperidin, naringin, and quercetin may boost the immune response and improve the wellbeing (Tang et al, 2012), by promoting cellular defense activity against oxidative stress (Karasu et al, 2014). Moreover, in agreement with the literature (Selvakumar et al, 2013), the dietary supplementation of hesperidin and quercetin decreased serum cholesterol and protein concentrations (Table 2).…”

Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase

“…Our observations on the hepatic tissues of treated diabetic rats with quercetin comparable with that ofSelvakumar et al (2013), who reported a protective effect of quercetin supplementation at the dosage of 50 mg/kg on histological changes in the liver of polychlorinated biphenyls-induced adult male Wistar rats. Our observations on the hepatic tissues of treated diabetic rats with quercetin comparable with that ofSelvakumar et al (2013), who reported a protective effect of quercetin supplementation at the dosage of 50 mg/kg on histological changes in the liver of polychlorinated biphenyls-induced adult male Wistar rats.…”

Histomorphological and biochemical changes induced by triptolide treatment in male lesser bandicoot rat, Bandicota bengalensis

“…The increase in various biochemical parameters showed the effect of triptolide treatment on metabolism of animals and this effect is closely related to the dose level, as increase in the various biochemical parameters is in a dose dependent manner. Increased levels of AST and ALT are usually indicative of liver damage in animals and humans [30]. ALP and ACP are considered as important integrity markers of cellular damage and are secreted by lysozymes.…”