Effect of quercetin and rutin in some acute seizure models in mice

Nieoczym, Dorota; Socała, Katarzyna; Raszewski, Grzegorz; Właź, Piotr

doi:10.1016/j.pnpbp.2014.05.007

Cited by 64 publications

(47 citation statements)

References 45 publications

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“…These data suggest that although the antioxidant activity of the extracts studied has been attributed to their metabolite content, the differences between the extracts may be due not only to their compositions. We must also consider the presence of other mechanisms that regulate the hyperexcitability induced by KA, such as positive modu-latory effects of flavonoids on inhibitory-type GABAergic neurotransmission [28][29][30] as well as modulatory effects on serotoninergic responses, which have been considered responsible for the effects of some flavonoids on responses to sedation and anxiolytics [31]. The exact anticonvulsant mechanism of action ME of H. inuloides remains unknown, but flavonoid metabolites such as quercetin are present [22], and it has not been ruled out that the anticonvulsant effect observed against KA-induced seizures can be attributed to both anticonvulsant and antioxidant capacities, which have been reported for this extract and its metabolite [22,32].…”

Section: Discussionmentioning

confidence: 99%

“…The aim of this study was to examine the protective effects of administration of methanolic and acetonic extracts and quercetin from H. inuloides (30,100, and 300 mg/kg) against damage in different brain areas of male Wistar rats treated with kainic acid (KA) with regard to behavior (severity and latency of seizures) and biochemical indices (activity of the antioxidants glutathione reductase (GR) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) and levels of oxidative damage markers such as malondialdehyde (MDA) and carbonylated proteins (CP).…”

Section: Introductionmentioning

confidence: 99%

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Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Carmona-Aparicio¹,

Cárdenas-Rodríguez²,

Delgado³

et al. 2019

Oxidative Medicine and Cellular Longevity

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Kainic acid (KA) has been used to study the neurotoxicity induced after status epilepticus (SE) due to activation of excitatory amino acids with neuronal damage. Medicinal plants can protect against damage caused by KA-induced SE; in particular, organic extracts of Heterotheca inuloides and its metabolite quercetin display antioxidant activity and act as hepatoprotective agents. However, it is unknown whether these properties can protect against the hyperexcitability underlying the damage caused by KA-induced SE. Our aim was to study the protective effects (with regard to behavior and antioxidant activity) of administration of natural products methanolic (ME) and acetonic (AE) extracts and quercetin (Q) from H. inuloides at doses of 30 mg/kg (ME30, AE30, and Q30 groups), 100 mg/kg (ME100, AE100, and Q100 groups), and 300 mg/kg (ME300, AE300, and Q300 groups) against damage in brain regions of male Wistar rats treated with KA. We found dose-dependent effects on behavioral and biochemical studies in the all-natural product groups vs. the control group, with decreases in seizure severity (Racine’s scale) and increases in seizure latency (p<0.05 in the ME100, AE100, Q100, and Q300 groups and p<0.01 in the AE300 and ME300 groups); on lipid peroxidation and carbonylated proteins in all brain tissues (p<0.0001); and on GPx, GR, CAT, and SOD activities with all the treatments vs. KA (p≤0.001). In addition, there were strong negative correlations between carbonyl levels and latency in the group treated with KA and in the group treated with methanolic extract in the presence of KA (r=‐0.9919, p=0.0084). This evidence suggests that organic extracts and quercetin from H. inuloides exert anticonvulsant effects via direct scavenging of reactive oxygen species (ROS) and modulation of antioxidant enzyme activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Carmona-Aparicio¹,

Cárdenas-Rodríguez²,

Delgado³

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Moreover anthraquinones present in T. chebula and quercetin derivatives in A. aspera were also reported for antiepileptic effect. [414243]…”

Section: Discussionmentioning

confidence: 99%

Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity

et al. 2016

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Background:Epilepsy is a serious and complex central nervous system disorder associated with recurrent episodes of convulsive seizures due to the imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmitters level in the brain. The available treatments are neither competent to control the seizures nor prevent progress of disease. Since ages, Herbal medicines have remained important sources of medicines in many parts of world which is evidenced through their uses in traditional systems of medicine i.e. Ayurveda, Siddha, Unani, Homeopathy and Chinese etc.Aim:A polyherbal formulation (containing Terminalia chebula Retz., Asparagus racemosus Willd., Embelia ribes Burm. F, Acorus calamus L., Tinospora cordifolia (Willd.) Miers, Convolvulus pluricaulis Choisy, Saussurea lappa C.B.Clarke, Achyranthes aspera L.) is mentioned in Ayurvedic classics Bhaiṣajya Ratnāvali. The aim of the study was to evaluate the anticonvulsant activity of the formulation in Maximum electroshock and Pentylenetetrazole induced convulsions in rats.Materials and Methods:In the present study, a polyherbal formulation was developed as directed by classical text and evaluated for the anticonvulsant activity using Maximal Electroshock Shock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. Statistical comparison was done by one way ANOVA followed by the Tukey's multiple comparison test.Results:The obtained results showed that the PHF had a protective role on epilepsy. Treatment with PHF significantly improves antioxidant enzymes activities of superoxide dismutase (SOD) and glutathione (GSH) levels significantly as compared to controls. PHF also significantly decreased malonaldialdehyde (MDA) levels in the brain. Moreover, it also attenuated the PTZ-induced increase in the activity of GABA-T in the rat brain.Conclusion:These findings suggest that PHF might have possible efficacy in the treatment of epilepsy.

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“…with valproate sodium or levetiracetam was safe, and quercetin did not change the anticonvulsant effects of either drug. Furthermore, quercetin did not result in any changes in the long-term memory (LTM) of mice with both treatments or individually (Nieoczym, Socała, Raszewski, & Wlaź, 2014).…”

Section: Neurological Diseases In Different Animal Models Of Memory Imentioning

confidence: 99%

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei

Mirzababaei

Nassiri‐Asl

2018

Journal of Food Science

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Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin's presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models. Several important pathways that may be involved in the processes of learning and memory, long-term potentiation, and cognition may be impaired during neurological diseases or other medical conditions. As dietary quercetin is important, provision of its best formulation for delivery to the brain as a nutraceutical and in clinical translational research for the prevention or treatment of Alzheimer's disease and other types of dementia is necessary.

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Effect of quercetin and rutin in some acute seizure models in mice

Cited by 64 publications

References 45 publications

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

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