Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer

Caddeo, Carla; Nácher, Amparo; Vassallo, Antonio; Armentano, Maria Francesca; Pons, Ramón; Fernàndez‐Busquets, Xavier; Carbone, Claudia; Valenti, Donatella; Fadda, Anna Maria; Manconi, Maria

doi:10.1016/j.ijpharm.2016.09.014

Cited by 127 publications

(77 citation statements)

References 26 publications

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“…Q was efficiently entrapped both in LP-Q and LP-Q+GA (EE % >85%), as a consequence of its lipophilic nature that favors its incorporation inside the lipid bilayer. This is in agreement with the reported high EE % for Q in liposomes, ranging from 67% to 89%, [56,[59][60][61]. Recently, Riva et al [41] also demonstrated that the employment of phytosomes can increase the solubility of this polyphenol, thus promoting the entrapment of Q into the vesicles.…”

Section: Polyphenols Entrapment Efficiencysupporting

confidence: 88%

“…We evaluated stability by using entrapment efficiency (Figure 1a No relevant changes in respect to size and PDI were detected for all formulations; moreover, polyphenol-containing liposomes appeared more stable than plain-LP ( Figure 1b). As reported earlier by other authors [56,59,60], Q was effectively retained inside liposomes over the course of 3 months, with no significant loss and no signs of degradation. On the contrary, the EE % of GA formulated alone tended to slowly decrease after more than one month of storage indicating leakage from liposomes.…”

Section: Stability Of Liposomal Preparationssupporting

confidence: 83%

“…Co-encapsulation of active molecules in the same nanocarrier is particularly attractive because it allows the simultaneous delivery of molecules to their target, thus simplifying and improving the therapy. To date, Q was successfully co-encapsulated in liposomes with resveratrol [56] and epigallocatechin-3-gallate [57], whereas GA was co-loaded with resveratrol [58]. These formulations were mainly focused on the treatment of skin pathologies related to microbial infections or oxidative stress.…”

Section: Polyphenols Entrapment Efficiencymentioning

confidence: 99%

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Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

et al. 2019

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Vulvovaginal candidiasis (VVC) is a widely spread fungal infection that causes itching, pain and inflammation at the vaginal site. Although common, currently available treatment suffers from limited efficacy and high recurrence. In addition, the growing problem of resistance to azole drugs used in current treatments emphasizes the need for superior treatment options. Antimicrobial polyphenols are an attractive approach offering multitargeting therapy. We aimed to develop novel liposomes for simultaneous delivery of two polyphenols (quercetin, Q, and gallic acid, GA) that, when released within the vaginal cavity, act in synergy to eradicate infection while alleviating the symptoms of VVC. Q was selected for its anti-itching and anti-inflammatory properties, while GA for its reported activity against Candida. Novel liposomes containing only Q (LP-Q), only GA (LP-GA) or both polyphenols (LP-Q+GA) were in the size range around 200 nm. Q was efficiently entrapped in both LP-Q and in LP-Q+GA (85%) while the entrapment of GA was higher in LP-Q+GA (30%) than in LP-GA (25%). Liposomes, especially LP-Q+GA, promoted sustained release of both polyphenols. Q and GA acted in synergy, increasing the antioxidant activities of a single polyphenol. Polyphenol-liposomes were not cytotoxic and displayed stronger anti-inflammatory effects than free polyphenols. Finally, LP-GA and LP-Q+GA considerably reduced C. albicans growth.

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Section: Polyphenols Entrapment Efficiencysupporting

confidence: 88%

Section: Stability Of Liposomal Preparationssupporting

confidence: 83%

Section: Polyphenols Entrapment Efficiencymentioning

confidence: 99%

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Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

et al. 2019

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“…In fact, there is evidence that resveratrol, quercetin and catechins have positive effects on aerobic capacity [30][31][32] and curcumin on preventing muscle damage [33]. Moreover, liposomal phenols are already extensively utilised in cancer treatment: resveratrol and catechins liposomes to target cancer cells [34,35], liposomal resveratrol combined with quercetin to improve pre-cancerous/cancerous skin lesions [36] and liposomal curcumin and resveratrol to prevent cancer [37]. Therefore, the already existing beneficial effects of these phenols might be augmented by the use of liposomal formulations within a sport and exercise context.…”

Section: Liposomal Technology and Sport And Exercise Nutritionmentioning

confidence: 99%

Liposomal Nanotechnology - A New Frontier for Sport and Exercise Nutrition?

Higgins¹

2016

JNMR

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“…The incidence of skin inflammatory diseases (dermatitis, psoriasis, rash) has increased significantly in the last decades and bioflavonoids such as quercetin, curcumin and baicalin have been widely used for treatment of this injures [1,2,3,4]. Citrus fruits peels represent an important source of phenolic acids and flavonoids, mainly polymethoxyflavones (PMFs), flavanones and glycosylated flavanones [5,6].…”

Section: Introductionmentioning

confidence: 99%

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

Pleguezuelos-Villa

Mir-Palomo

Dı́ez-Sales

et al. 2018

Colloids and Surfaces B: Biointerfaces

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The article has 4636 words including ackwonledgment and references. The abstract has 127 words. There are 5 figures and 2 tables. Highlights Nanovesicles were small in size and monodispersed independently of the NA concentration. No citotoxity effects were observed in 3T3 fibroblasts treated with ultradeformable liposomes. Ultradeformable liposomes have the ability to reduce skin inflammation. Graphical abstract AbstractUltradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9 mg/mL). Nanovesicles were small size (~100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (~88%) and a highly negative zeta potential (around -30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts.In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (~ 10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.

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Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer

Cited by 127 publications

References 26 publications

Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

Liposomal Nanotechnology - A New Frontier for Sport and Exercise Nutrition?

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

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