Effect of quality sperm and DNA damage by thallium exposure in mice mature sperm

Rojas-Alonzo, R.; Núñez-Tapia, F.A.; Moreno‐Godínez, Ma. Elena; Talavera-Mendoza, Óscar; Ortuño-Pineda, Carlos; Quintanilla‐Vega, Betzabet; Solís-Heredia, M.J.; Rodríguez‐Mercado, Juan José; Urióstegui-Acosta, Mayrut

doi:10.1016/j.toxlet.2016.07.558

Cited by 1 publication

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“…Exposure of human blood cells to Tl (I) increases the length of the comet assay [71]. Furthermore, Tl (I) causes a decrease in both the viability and motility of mature mouse sperm, along with an increase in fragmented DNA [72]. In mouse neuroblastoma cells (Neuro-2A), acetylcholinesterase activity is highly sensitive to inhibition by Tl [73].…”

Section: Genotoxicity and Other Adverse Effects Of Thalliummentioning

confidence: 99%

The Impact of Thallium Exposure in Public Health and Molecular Toxicology: A Comprehensive Review

Chang,

Chiang

2024

IJMS

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This review offers a synthesis of the current understanding of the impact of low-dose thallium (Tl) on public health, specifically emphasizing its diverse effects on various populations and organs. The article integrates insights into the cytotoxic effects, genotoxic potential, and molecular mechanisms of thallium in mammalian cells. Thallium, a non-essential heavy metal present in up to 89 different minerals, has garnered attention due to its adverse effects on human health. As technology and metallurgical industries advance, various forms of thallium, including dust, vapor, and wastewater, can contaminate the environment, extending to the surrounding air, water sources, and soil. Moreover, the metal has been identified in beverages, tobacco, and vegetables, highlighting its pervasive presence in a wide array of food sources. Epidemiological findings underscore associations between thallium exposure and critical health aspects such as kidney function, pregnancy outcomes, smoking-related implications, and potential links to autism spectrum disorder. Thallium primarily exerts cellular toxicity on various tissues through mitochondria-mediated oxidative stress and endoplasmic reticulum stress. This synthesis aims to shed light on the intricate web of thallium exposure and its potential implications for public health, emphasizing the need for vigilant consideration of its risks.

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Section: Genotoxicity and Other Adverse Effects Of Thalliummentioning

confidence: 99%