Effect of pyridoxine plus pyridostigmine treatment on vincristine-induced peripheral neuropathy in pediatric patients with acute lymphoblastic leukemia: a single-center experience

Köker, Sultan Aydın; Gözmen, Salih; Demirağ, Bengü; Ünalp, Aycan; Karapınar, Tuba Hilkay; Oymak, Yeşim; Gürbüz, Gürkan; Öner, Ecem İpek; Vergin, Raziye Canan

doi:10.1007/s10072-020-04970-w

Cited by 13 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Meanwhile, the excessive B6 intake could also lead to progressive sensory peripheral neuropathy and the neurological symptoms including paresthesia, hyperesthesia, bone pain, muscle weakness, numbness, fasciculations, and loss of tendon reflexes [13 ▪ ]. Combination of pyridoxine and pyridostigmine was effective in vincristine-induced peripheral neuropathy in pediatric patients with acute lymphoblastic leukemia [14]. In contrast, B6 levels was also reported not correlated with severity of neuropathy in chronic idiopathic axonal polyneuropathy [15].…”

Section: B Vitaminsmentioning

confidence: 99%

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

View full text Add to dashboard Cite

Purpose of review Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. Recent findings The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. Summary The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.

show abstract

Section: B Vitaminsmentioning

confidence: 99%

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

View full text Add to dashboard Cite

show abstract

“…The use of pyridoxine (Vitamin B6) and pyridostigmine for the prevention of CIPN has shown some benefit. Pyridostigmine is used to enhance decreased gastrointestinal motility in children (Manini et al, 2018;Aydin Koker et al, 2021). Case reports suggest that pyridoxine alleviates vincristine-induced neuropathy in children (Jackson et al, 1986;Muller et al, 2004;Duman et al, 2005;Ngamphaiboon et al, 2010;Aydin Koker et al, 2021).…”

Section: Pharmacological Managementmentioning

confidence: 99%

“…Pyridostigmine is used to enhance decreased gastrointestinal motility in children (Manini et al, 2018;Aydin Koker et al, 2021). Case reports suggest that pyridoxine alleviates vincristine-induced neuropathy in children (Jackson et al, 1986;Muller et al, 2004;Duman et al, 2005;Ngamphaiboon et al, 2010;Aydin Koker et al, 2021). Additionally, various studies performed in adult patient populations have demonstrated that vitamin D deficiency increases the severity of CIPN, while supplementing vitamin D during chemotherapy may improve neuropathy symptoms (Wang et al, 2016;Grim et al, 2017;Jennaro et al, 2020;Yildirim and Cengiz, 2020).…”

Section: Pharmacological Managementmentioning

confidence: 99%

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients

Tay

Laakso

Schweitzer

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. CIPN can greatly impair quality of life and increases morbidity of pediatric patients with cancer, with the accompanying symptoms frequently remaining underdiagnosed. Little is known about the incidence of CIPN, its impact on the pediatric population, and the underlying pathophysiological mechanisms, as most existing information stems from studies in animal models or adult cancer patients. Herein, we aim to provide an understanding of CIPN in the pediatric population and focus on the 6 main substance groups that frequently cause CIPN, namely the vinca alkaloids (vincristine), platinum-based antineoplastics (cisplatin, carboplatin and oxaliplatin), taxanes (paclitaxel and docetaxel), epothilones (ixabepilone), proteasome inhibitors (bortezomib) and immunomodulatory drugs (thalidomide). We discuss the clinical manifestations, assessments and diagnostic tools, as well as risk factors, pathophysiological processes and current pharmacological and non-pharmacological approaches for the prevention and treatment of CIPN.

show abstract

“…В отдельных исследованиях проведена оценка результативности некоторых препаратов у детей с ВП. Одни авторы в рандомизированных контролируемых исследованиях рассматривали глутаминовую кислоту, относящуюся к метаболическим средствам, получив противоречивые выводы [23,24], другие -показали положительное влияние пиридоксина, описав небольшую группу пациентов [25]. Из-за недостаточных доказательств эффективности медикаментозной терапии, в последние годы обсуждается роль физических упражнений в лечении химиоиндуцированной полиневропатии.…”

Section: Introductionunclassified

Results of evaluation of neurometabolic and rehabilitation therapy for vincristine polyneuropathy in children with acute lymphoblastic leukemia

Koryakina,

Kovtun,

Fechina

et al. 2023

Урал. мед. журнал

View full text Add to dashboard Cite

Introduction. Vincristine-induced peripheral neuropathies (VIPN) is a current problem in the management of pediatric acute lymphoblastic leukemia (ALL). There are no effective therapeutic strategies for VIPN. The aim of the study to present the results of evaluation of neurometabolic therapy in the acute period of VIPN in children with ALL and the method of virtual rehabilitation in the recovery period. Materials and methods. The single-center prospective comparative pilot study involved 69 children with VIPN who were treated in the acute period with the following drugs: group 1 - pyridoxine, group 2 - thioktovic acid, group 3 - inosine + nicotinamide + riboflavin + succinic acid. Clinical and electrophysiological parameters before and after drug treatment were analyzed. Among 10 children with motor deficits in the lower extremities in the recovery period of VIPN, rehabilitation with immersive virtual reality was performed, and the clinical parameters before and after the course were compared. Results. A positive effect of the studied drugs on the clinical condition of patients by the 30th day of therapy was revealed. In groups 1 and 3 the total score on the NIS-LL scale correlated with mild polyneuropathy - 4 [2÷8] and 2 [2÷6] points, respectively. Neurologic impairment in each of these groups persisted for 19 [14÷25] and 19 [13÷30] days, which was less in contrast to the duration of symptoms in group 2 (p1-2 = 0.021 and p2-3 = 0.046). In the VIPN recovery period before and after virtual rehabilitation: muscle strength in the lower limbs increased (p = 0.025); the severity of polyneuropathy decreased according to the NIS-LL scale (p = 0.003); balance improved according to the Berg scale (p = 0.017); and patients’ mobility increased according to the Functional Walking Category test (p = 0.025) and walking speed according to the time-recorded walking test (p = 0.008). Discussion. Improvement of clinical parameters with neurometabolic therapy and virtual rehabilitation in children with VIPN has been shown. Conclusion. Preliminary results of the effectiveness of pyridoxine and inosine + nicotinamide + riboflavin + succinic acid in the acute period of VIPN in children with ALL and the method of virtual rehabilitation in the recovery period were obtained.

show abstract

Effect of pyridoxine plus pyridostigmine treatment on vincristine-induced peripheral neuropathy in pediatric patients with acute lymphoblastic leukemia: a single-center experience

Cited by 13 publications

References 21 publications

Vitamins in neuropathy: pathophysiological and therapeutic roles

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients

Results of evaluation of neurometabolic and rehabilitation therapy for vincristine polyneuropathy in children with acute lymphoblastic leukemia

Contact Info

Product

Resources

About