Effect of PVA on the gel temperature of MC and release kinetics of KT from MC based ophthalmic formulations

Synergistic effect of salt mixture on the gelation temperature and morphology of methylcellulose hydrogel

“…It is likely that the mechanical properties of this solution is highly dependent on intra and inter molecular hydrogen bonds between OH groups of MC molecules. Measurement of G is a powerful tool to determine the gelation temperature as reported earlier [32][33][34]. Gel strength is an important factor in the field of sustained release of drug, so it is an essential method, which evaluates the gelation temperature as well as the gel strength.…”

“…The polymer solution moves towards gel during heating and so G increases. The crossover point of G and G indicates the gelation temperature [31][32][33][34]. From Fig.…”

Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications

“…Different techniques have been developed for the determination of the Tsol-gel. The simplest method is test tube inversion where a test tube containing the sample is repeatedly tilted in a gradually heated water bath and recording the temperature at which no flow occurs (Figure 2A) [23]. Another simple method includes heating the sample gradually on a magnetic stirrer and recording the temperature at which the magnetic bar stops moving [24].…”

3d Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

“…Informed by our experience with hematopoietic cell culture and bioinks previously reported in the literature, we created a bioink comprised of methylcellulose (MC) and alginate. MC is a thermally-gelling polymer widely used as a binder, thickener, or emulsifier in industrial applications, but is gaining popularity for its value in biomedical applications, including drug delivery and cell culture [32][33][34][35][36]. Alginate, similarly, is a frequently used material for bioink development due to its rapid ion dependent crosslinking and shear thinning behavior [37,38].…”