Effect of purified scorpion toxin on vesicular components in the myenteric plexus of the rat

Tafuri, Washington Luiz; Maria, T. A.; Freire-Maia, L.; Melo, J.R. Cunha

doi:10.1016/0041-0101(71)90142-5

Cited by 10 publications

(2 citation statements)

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“…Scorpion venom has been shown to increase the release of acetylcholine from slices of rat brain (Gomez et al, 1973) and segments of guinea-pig ileum (Diniz and Torres, 1968). It enhances the release of preloaded [U-'4C]glutamate and [U-I4C]GABA from rat cortical synaptosomes (Dolly et al, 1978), and there is evidence that it releases catecholamines from rat rnyenteric plexus (Tafuri et al, 1971). Tityustoxin, the active component of the venom which has been used in these studies, appears to work by depolarising nerve terminals through an action at the 'active' sodium channel (Linden and Raftery, 1976).…”

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confidence: 99%

The Effects of Scorpion Venom Toxin on the Release of Amino Acid Neurotransmitters from Cerebral Cortex In Vivo and In Vitro

Coutinho‐Netto

Abdul-Ghani

Norris

et al. 1980

Journal of Neurochemistry

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Tityustoxin, the active component of the venom of the Brazilian yellow scorpion Tityus serrulatus, caused specific release of the neurotransmitter amino acids glutamate, aspartate and GABA in vivo from the superfused sensori-motor cortex of conscious unanesthetised rats and in vitro from rat cortical synaptosomes. The effects on synaptosomes appear to be due to a depolarising action. Synaptosomal potassium levels were depleted by the toxin. The action was also blocked both in vivo and in vitro by tetrodotoxin and was Ca2+-dependent. The uptake of [U-14C]GABA was inhibited by tityustoxin but this action was prevented by tetrodotoxin (1 microM). Since the release of [U-14C]GABA from synaptosomes due to the tityustoxin was also prevented by tetrodotoxin under identical circumstances, it is concluded that the tityustoxin has a primary action on release of neurotransmitters rather than on uptake.

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mentioning

confidence: 99%

The Effects of Scorpion Venom Toxin on the Release of Amino Acid Neurotransmitters from Cerebral Cortex In Vivo and In Vitro

Coutinho‐Netto

Abdul-Ghani

Norris

et al. 1980

Journal of Neurochemistry

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“…serrulatus produz uma série de efeitos sobre o homem e animais como: salivação e secreção gástrica excessiva, vômito e contração ou relaxamento dos músculos lisos intestinais (Campos et al, 1979;Catanzaro et al, 1978;Cunha-Melo et al, 1973;Diniz and Valeri, 1959;Freire-Maia and Diniz, 1970;Tafuri et al, 1971) (Andrade et al, 1981;Gonzaga et al, 1979). Também foi demonstrada a ocorrência de pancreatite aguda em animais sob a ação do veneno do escorpião do gênero Tityus (Bartholomew et al, 1976) (Sankaran et al, 1977).…”

Section: Fontes Alternativas De Células ß Para O Transplanteunclassified

Ilhotas pancreáticas humanas viáveis para o transplante através do aumento da massa de células e do imunoisolamento com microcápsulas biocompatíveis

Campos-Lisbôa¹

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Agradeço aos meus pais, Márcio e Marisa, pelo amor incondicional e confiança, os quais me fizeram ter forças sempre para levantar a cabeça, sacudir a poeira e seguir em frente. "O essencial é invisível aos olhos, só se vê bem com o coração" Antoine de Saint-Expuréy. Agradeço ao meu esposo Marcílio, por ter sido companheiro de sonhos e já de algumas realizações. Obrigada por acreditar em mim, por acreditar que valia a pena, e por isso, obrigada pela espera. "(...)que seja infinito enquanto dure" Vinícius de Moraes. Obrigada aos meus irmãos e melhores amigos, Marília Gabriela e Márcio Henrique, pelo apoio incondicional. Vocês são para mim o ontem, o hoje e o sempre. Um porto seguro, amo muito vocês. "Viver e não ter a vergonha de ser feliz" Gonzaguinha.

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Studies on the Mechanism of Action of Tityustoxin

Freire-Maia

Cunha-Melo

Gomez

et al. 1976

Animal, Plant, and Microbial Toxins

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Effect of purified scorpion toxin on vesicular components in the myenteric plexus of the rat

Cited by 10 publications

References 2 publications

The Effects of Scorpion Venom Toxin on the Release of Amino Acid Neurotransmitters from Cerebral Cortex In Vivo and In Vitro

The Effects of Scorpion Venom Toxin on the Release of Amino Acid Neurotransmitters from Cerebral Cortex In Vivo and In Vitro

Ilhotas pancreáticas humanas viáveis para o transplante através do aumento da massa de células e do imunoisolamento com microcápsulas biocompatíveis

Studies on the Mechanism of Action of Tityustoxin

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