Effect of pulsed dye laser on intercellular adhesion molecule-1 (ICAM-1) expression after treatment of psoriasis

Soliman, Mona; Zaher, Hesham; Danasouri, Nabil El; Attia, Abeer; Tawfik, Waguih

doi:10.1016/j.mla.2010.03.002

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Both substance P 43 and NGF 36 are upregulated in active psoriatic skin lesions. Interestingly, expression of endothelial adhesion molecules (ICAM‐I, E‐selectin and αVβ3 integrin) decreased 40%–75% after PDL treatment of psoriasis 5,9,44 . We suggest it is plausible that the deprivation of molecules related to neuro‐inflammation through hyper‐thermal denervation by PDL treatment relates to the improvement or remission of the psoriatic plaque.…”

Section: Nerve Injury Resolves Psoriatic Plaquesmentioning

confidence: 87%

“…Interestingly, expression of endothelial adhesion molecules (ICAM-I, E-selectin and αVβ3 integrin) decreased 40%-75% after PDL treatment of psoriasis. 5,9,44 We suggest it is plausible that the deprivation of molecules related to neuroinflammation through hyper-thermal denervation by PDL treatment relates to the improvement or remission of the psoriatic plaque. As supporting evidence, a single treatment with the PDL for rosacea was associated with a significant decrease in epidermal nerve fibre density, 45 and a decrease in substance P. 46…”

Section: Nerve Inj Ury Re Solve S Psoriati C Pl Aq U E Smentioning

confidence: 95%

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Effects of pulsed dye laser treatment in psoriasis: A nerve‐wrecking process?

Doppegieter

Beek

Bakker

et al. 2023

Experimental Dermatology

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Pulsed dye laser (PDL) therapy can be effective in treating psoriasis, with a long duration of remission. Although PDL therapy, albeit on a modest scale, is being used for decades now, the underlying mechanisms responsible for the long‐term remission of psoriasis remain poorly understood. The selective and rapid absorption of energy by the blood causes heating of the vascular wall and surrounding structures, like perivascular nerves. Several studies indicate the importance of nerves in psoriatic inflammation. Interestingly, denervation leads to a spontaneous remission of the psoriatic lesion. Among all dermal nerves, the perivascular nerves are the most likely to be affected during PDL treatment, possibly impairing the neuro‐inflammatory processes that promote T‐cell activation, expression of adhesion molecules, leukocyte infiltration and cytokine production. Repeated PDL therapy could cause a prolonged loss of innervation through nerve damage, or result in a ‘reset’ of neurogenic inflammation after temporary denervation. The current hypothesis provides strong arguments that PDL treatment affects nerve fibres in the skin and thereby abrogates the persistent and exaggerated inflammatory process underlying psoriasis, causing a long‐term remission of psoriasis.

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Section: Nerve Injury Resolves Psoriatic Plaquesmentioning

confidence: 87%

Section: Nerve Inj Ury Re Solve S Psoriati C Pl Aq U E Smentioning

confidence: 95%

Effects of pulsed dye laser treatment in psoriasis: A nerve‐wrecking process?

Doppegieter

Beek

Bakker

et al. 2023

Experimental Dermatology

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“…Moreover, through the subsequent dissipation of this heat, SPL can also affect some perivascular regions (depending on the laser pulse duration, vessel size, and location) 19 . In addition to direct effects of heating, such as coagulation or rupture of blood vessels, SPL can also induce secondary effects which may include suspending several of the processes that characterize psoriasis, such as angiogenesis, 20 inflammatory cytokine production, 21 leukocyte‐infiltration via endothelial adhesion molecules, 22 and keratinocyte proliferation 23 . Furthermore, SPL may reduce the peripheral nerve fiber density and secretion of neuropeptides, which are both known to regulate the pathogenesis of psoriatic lesions 24 .…”

Section: Introductionmentioning

confidence: 99%

Modeling pulsed dye laser treatment of psoriatic plaques by combining numerical methods and image‐derived lesion morphologies

Wilk,

Doppegieter,

van der Beek

et al. 2024

Lasers Surg Med

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ObjectivesKnowledge of the physical effects of pulsed dye laser (PDL) treatment of psoriatic lesions is essential in unraveling the remedial mechanisms of this treatment and hence also in maximizing in its disease‐modifying potential. Therefore, the main objective of this study was to provide estimates of these physical effects (for laser wavelengths of 585 and 595 nm), with the aim of identifying pathogenic processes that may be affected by these conditions.MethodsWe modeled the laser light propagation and subsequent photothermal heating by numerically solving the transient diffusion and heat equations simultaneously. To this end, we used the finite element method in conjunction with an image‐derived psoriatic lesion morphology (which was defined by segmenting blood vessels from a confocal microscopy image of a fluorescently labeled section of a 3 mm punch biopsy of a psoriatic lesion). The resulting predictions of the generated temperature field within the lesion were then used to assess the possibility of stalling or arresting some suspected pathogenic processes.ResultsAccording to our results, it is conceivable that perivascular nerves are thermally denatured, as almost all locations that reach 60°C were found to be within 18 µm (at 585 nm) and 11 µm (at 595 nm) of a blood vessel wall. Furthermore, activation of TRPV1 and TRPV2 channels in perivascular neuronal and immune cells is highly likely, since a critical temperature of 43°C is generated at locations within up to 350 µm of a vessel wall (at both wavelengths) and sustained for up to 700 ms (at 585 nm) and 40 ms (at 595 nm), while a critical temperature of 52°C is reached by locations within 80 µm (at 585 nm) and 30 µm (at 595 nm) of a vessel wall and sustained for up to 100 ms (at 585 nm) and 30 ms (at 595 nm). Finally, we found that the blood vessel coagulation‐inducing temperature of 70°C is sustained in the vascular epithelium for up to 19 and 5 ms at 585 and 595 nm, respectively, rendering partial or total loss of vascular functionality a distinct possibility.ConclusionsThe presented approach constitutes a useful tool to provide realistic estimates of the photothermal effects of PDL treatment of psoriatic plaques (as well as other selective photothermolysis‐based treatments), yielding information that is essential in guiding future experimental studies toward unraveling the remedial mechanisms of these treatments.

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