1990
DOI: 10.1007/bf03349521
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Effect of pulsatile luteinizing hormone — releasing hormone administration on pituitary — gonadal function in elderly man

Abstract: The effect of short-term pulsatile LHRH administration was studied in 8 healthy subjects ranging from 60 to 81 yr to see if the decrease of pituitary gonadal function could be in part due to changes in the discharge of LHRH from the hypothalamus. Gonadotropin and testosterone (T) secretion was evaluated two weeks before and during LHRH (122-160 ng/kg bw every 120 min sc) infusion. In addition, a bolus dosage of LHRH (50 mu iv) was given both at the beginning and at the end of pulsatile LHRH administration in o… Show more

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Cited by 10 publications
(2 citation statements)
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“…The neurokinin B containing neurons are probably involved in the regulation of the HPG-axis and have been related to menopausal flushes (Rance, 1992). The sensitivity of LH to LHRH did not decrease in elderly males (Giusti et al, 1990;Kaufman et al, 1990Kaufman et al, , 1991. On the other hand, a decreased sensitivity to sex steroid feedback was found in elderly (80 years) postmenopausal women as compared to younger postmenopausal women (55 years) (Rossmanith et al, 1994).…”
Section: Infundibular (Arcuate) Nucleusmentioning
confidence: 87%
“…The neurokinin B containing neurons are probably involved in the regulation of the HPG-axis and have been related to menopausal flushes (Rance, 1992). The sensitivity of LH to LHRH did not decrease in elderly males (Giusti et al, 1990;Kaufman et al, 1990Kaufman et al, , 1991. On the other hand, a decreased sensitivity to sex steroid feedback was found in elderly (80 years) postmenopausal women as compared to younger postmenopausal women (55 years) (Rossmanith et al, 1994).…”
Section: Infundibular (Arcuate) Nucleusmentioning
confidence: 87%
“…Postmenopausal women respond to gonadal steroid replacement with youthful gonadotropin dynamics, including positive feedback. 14 The effects of short-term pulsatile GnRH administration on pituitary gonadal function in elderly men was investigated by Giusti et al 49 Healthy subjects ranging from 62 to 81 years of age were studied to determine if decreased pituitary-gonadal function could be due in part to changes in the release of GnRH from the hypothalamus. GnRH was administered exogenously in a pulsatile fashion and significant bursts of LH were elicited in five out of eight subjects, indicating that the anterior pituitary gland of elderly men remains capable of pulsatile administration of GnRH.…”
Section: Pituitary Response To Gnrh In Men and Women During Agingmentioning
confidence: 99%