Effect of Psychopharmacotherapy on Body Mass Index Among Children and Adolescents with Bipolar Disorders

Patel, Ayush; Chan, Wenyaw; Aparasu, Rajender R.; Ochoa-Perez, Melissa; Sherer, Jeffrey T.; Medhekar, Rohan; Chen, Hua

doi:10.1089/cap.2016.0133

Cited by 16 publications

(14 citation statements)

References 44 publications

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“…The CEMR database has been extensively used for health outcome academic research worldwide in the fields of diabetes [ 21 - 26 ], cardiovascular research [ 27 - 31 ], obesity [ 32 - 34 ], inflammatory diseases [ 35 - 38 ], mental health [ 39 - 41 ], and other diseases [ 42 , 43 ]. To draw meaningful inferences from such studies and to generalize the results, it is essential to understand the underlying population.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Representativeness of US Centricity Electronic Medical Records With Reports From the Centers for Disease Control and Prevention: Comparative Study on Office Visits and Cardiometabolic Conditions

Montvida¹,

Dibato²,

Paul³

2020

JMIR Med Inform

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Background Electronic medical record (EMR)–based clinical and epidemiological research has dramatically increased over the last decade, although establishing the generalizability of such big databases for conducting epidemiological studies has been an ongoing challenge. To draw meaningful inferences from such studies, it is essential to fully understand the characteristics of the underlying population and potential biases in EMRs. Objective This study aimed to assess the generalizability and representativity of the widely used US Centricity Electronic Medical Record (CEMR), a primary and ambulatory care EMR for population health research, using data from the National Ambulatory Medical Care Surveys (NAMCS) and the National Health and Nutrition Examination Surveys (NHANES). Methods The number of office visits reported in the NAMCS, designed to meet the need for objective and reliable information about the provision and the use of ambulatory medical care services, was compared with similar data from the CEMR. The distribution of major cardiometabolic diseases in the NHANES, designed to assess the health and nutritional status of adults and children in the United States, was compared with similar data from the CEMR. Results Gender and ethnicity distributions were similar between the NAMCS and the CEMR. Younger patients (aged <15 years) were underrepresented in the CEMR compared with the NAMCS. The number of office visits per 100 persons per year was similar: 277.9 (95% CI 259.3-296.5) in the NAMCS and 284.6 (95% CI 284.4-284.7) in the CEMR. However, the number of visits for males was significantly higher in the CEMR (CEMR: 270.8 and NAMCS: 239.0). West and South regions were underrepresented and overrepresented, respectively, in the CEMR. The overall prevalence of diabetes along with age and gender distribution was similar in the CEMR and the NHANES: overall prevalence, 10.1% and 9.7%; male, 11.5% and 10.8%; female, 9.1% and 8.8%; age 20 to 40 years, 2.5% and 1.8%; and age 40 to 60 years, 9.4% and 11.1%, respectively. The prevalence of obesity was similar: 42.1% and 39.6%, with similar age and female distribution (41.5% and 41.1%) but different male distribution (42.7% and 37.9%). The overall prevalence of high cholesterol along with age and female distribution was similar in the CEMR and the NHANES: overall prevalence, 12.4% and 12.4%; and female, 14.8% and 13.2%, respectively. The overall prevalence of hypertension was significantly higher in the CEMR (33.5%) than in the NHANES (95% CI: 27.0%-31.0%). Conclusions The distribution of major cardiometabolic diseases in the CEMR is comparable with the national survey results. The CEMR represents the general US population well in terms of office visits and major chronic conditions, whereas the potential subgroup differences in terms of age and gender distribution and prevalence may differ and, therefore, should be carefully taken care of in future studies.

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Section: Introductionmentioning

confidence: 99%

Evaluating the Representativeness of US Centricity Electronic Medical Records With Reports From the Centers for Disease Control and Prevention: Comparative Study on Office Visits and Cardiometabolic Conditions

Montvida¹,

Dibato²,

Paul³

2020

JMIR Med Inform

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“…Few studies have identified predictors of antipsychoticrelated weight gain in youths with schizophrenia spectrum disorders, and no moderators have been identified. In terms of predictors of weight gain in adults and youth, the only definitive predictor is which particular antipsychotic is prescribed, with most studies finding that atypical antipsychotics (e.g., risperidone and olanzapine) cause more weight gain than first-generation antipsychotics (e.g., molindone) and that olanzapine is particularly obesogenic (Fraguas et al 2011;Mostafavi et al 2017;Patel et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Predictors and Moderators of Antipsychotic-Related Weight Gain in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study

Taylor

Jakubovski

Gabriel

et al. 2018

Journal of Child and Adolescent Psychopharmacology

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We identified prognostic subgroups and novel risk factors for antipsychotic-related weight gain. We confirmed that antipsychotic choice is extremely important for predicting future weight gain. We also found that younger age did not predict greater weight gain, in contrast to prior studies. Our findings require replication in an independent sample because we did not adjust for multiple comparisons to minimize false negatives. ClinicalTrials.gov Identifier: NCT00053703.

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“…Atypical antipsychotics are a widely prescribed group of psychotropic drugs. While having distinct advantages over the conventional antipsychotics, they are associated with metabolic adverse effects such as obesity, hyperglycemia, and dyslipidemia [ 1 – 3 ]. Since a large number of patients on atypical antipsychotics are likely to be children and young adults, these metabolic adverse effects can lead to significant morbidity and mortality over the long term, although the link between the use of antipsychotics and mortality is not well established [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials

Kamath

Rather

2018

BioMed Research International

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The objective of our study was to determine the effect of melatonin administration on atypical antipsychotic-induced metabolic adverse effects in patients with psychiatric disorders. A systematic search was performed in PUBMED, Cochrane Library, Scopus, Web of Science, and EBSCOhost electronic databases. Randomized controlled trials studying the effect of melatonin on antipsychotic-induced metabolic adverse effects were identified and subjected to meta-analysis. Four studies were included in the meta-analysis, including 57 patients on melatonin and 61 patients on placebo. Melatonin produced a significant decrease in the diastolic blood pressure compared with placebo (mean difference = −4.44 [95% CI, −7.00 to −1.88]; p = 0.0007; I2 = 13%), but not the systolic blood pressure (mean difference = −4.23 [95% CI, −8.11 to −0.36]; p = 0.03; I2 = 0%). Although a decrease in the body mass index was seen in the melatonin group, the difference was not significant in the random-effects analysis model. To conclude, in patients on atypical antipsychotics, melatonin at a dose of up to 5 mg/day for a treatment duration of up to 12 weeks attenuated the rise in diastolic blood pressure compared with placebo but had no significant effects on other metabolic parameters.

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Effect of Psychopharmacotherapy on Body Mass Index Among Children and Adolescents with Bipolar Disorders

Abstract: The long-term use of atypical antipsychotics, both as monotherapy or in combination with other psychotropic medications in children and adolescents with bipolar disorder, was associated with a steady and cumulative increase in BMI.

Cited by 16 publications

References 44 publications

Evaluating the Representativeness of US Centricity Electronic Medical Records With Reports From the Centers for Disease Control and Prevention: Comparative Study on Office Visits and Cardiometabolic Conditions

Evaluating the Representativeness of US Centricity Electronic Medical Records With Reports From the Centers for Disease Control and Prevention: Comparative Study on Office Visits and Cardiometabolic Conditions

Predictors and Moderators of Antipsychotic-Related Weight Gain in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study

Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials

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