Effect of psoriatic arthritis on the strength, proprioception, skill, coordination, and functional condition of the hand

Abstract

Background: This study was planned to evaluate the strength, proprioception, skill, coordination, and functional condition of the hand in individuals with psoriatic arthritis and to correlate disease activity with these parameters.Methods: Fifty-six individuals (psoriatic arthritis group, n = 36; control group, n = 20)were included in the study. Evaluations were performed of disease activity with Disease Activity Score 28; grip strength with a dynamometer and pinch strength with pinch gauge dynamometers; joint position sensation with a goniometer; finger skills with a mobile application; and coordination and skill of both hands with the Purdue Pegboard test. The Michigan Hand Outcomes Questionnaire (MHQ) was used for hand functional evaluation.Results: There was a significant difference between the grip and pinch strength of the psoriatic arthritis group and the control group (P < 0.05). There was no significant difference between the joint position sense measurements and the mobile application scores between the groups (P > 0.05). Purdue Pegboard scores showed a significant difference only in both hands and assembly subsections (P < 0.05). With Disease Activity Score 28, significant correlations were found between grip and pinch strength, mobile application scores, Purdue Pegboard all subsections, and lefthand joint position sense average error amount, and between MHQ and grip and pinch strength. Conclusions:This study is the first to show that psoriatic arthritis has a negative effect especially on hand strength; grip strength decreases as disease severity increases and, skill, coordination, and functionality of hand deteriorate.

Psoriasis, Is It a Microdamage of Our “Sixth Sense”? A Neurocentric View

“…Proske and Gandevia suggested that damaging forced lengthening contractions are to blame for impaired proprioception [ 39 ]. Notably, research is also emerging that impaired proprioception is part of the clinical picture of psoriatic arthritis [ 40 , 41 , 42 ], not to mention the accumulating evidence on the involvement of neurogenic mechanisms in the disease pathomechanism of psoriasis [ 43 , 44 ]. Furthermore, the existence of an underlying systemic silent pathophysiology is telling; new psoriatic lesions could evolve due to mechanical injury on previously uninvolved [ 45 ], already dysregulated skin areas [ 46 ].…”

Safe and Effective Subcutaneous Self-Injection of Bimekizumab with Safety Syringe and Auto-Injector Devices: Results from a Multicenter, Randomized, Open-Label Study in Patients with Psoriatic Arthritis

“… 13–15 As these symptoms may impact hand grip and function, it is important to evaluate safe and effective self-injection of bimekizumab in patients with active PsA. 16 , 17 …”

“…[13][14][15] As these symptoms may impact hand grip and function, it is important to evaluate safe and effective self-injection of bimekizumab in patients with active PsA. 16,17 Here, the results from DV0004 (NCT04109976), a sub-study of the Phase 3 study BE VITAL (NCT04009499) are presented. The study evaluated safe and effective self-injection of bimekizumab by patients with PsA using the 1 mL bimekizumab SSy or the 1mL AI.…”