Effect of Pseudomonas stutzeri F2 on rearing water quality and growth, innate immunity, visceral morphology and gut microbiota structure of juvenile spotted seabass (Lateolabrax maculatus)

Fu, Weilai; Duan, Peifeng; Wang, Qiang; Song, Junying; Wang, Yunshuang; Zhang, Zhen; Wang, Pan; Jiang, Huihui; Zhang, Xian; Song, Guolong; Rao, Zhiming

doi:10.1016/j.aqrep.2023.101536

Cited by 1 publication

(1 citation statement)

References 77 publications

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“…At the genus level, the relative abundances of Pseudomonas, Acinetobacter, and Tyzzerella were increased in mice with colitis. Pseudomonas is a Gram-negative pathogen and is strongly related to the development of some inflammatory diseases [35]. Acinetobacter is a complex and heterogeneous class of bacteria, and is widely present in patients with intestinal diseases [36].…”

Section: Inosine Induced the Inhibition Of Pathogenic Bacteria And Th...mentioning

confidence: 99%

Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms

Guo,

Tang,

Zhang

et al. 2023

IJMS

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Background: Colonic and serum inosine are significantly reduced in patients with inflammatory bowel disease (IBD). Methods: This study aimed to explore whether microbiome-derived inosine alleviates colitis and its underlying mechanisms. Results: An inosine intervention effectively improved the clinical signs in colitis mice, suppressed inflammatory cytokines (tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β) by regulating the nuclear factor-kappa B (NF-κB) pathway, and elevated the activities of anti-oxidative enzymes (including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)) by regulating the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway. Additionally, the inosine intervention significantly elevated the expression of tight junction proteins (ZO-1, occudin, and claudin-1) in mice with colitis. High-throughput sequencing revealed that the inosine intervention also prevented gut microbiota disorder by increasing the abundance of beneficial bacteria (Lachnospiraceae NK4A136 group, Romboutsia, Marvinbryantia, Clostridium sensu stricto 1, and Bifidobacterium) and reducing the abundance of harmful bacteria (Pseudomonas, Acinetobacter, and Tyzzerella) in mice with colitis. Conclusions: Inosine played a significant role in mitigating colitis-related intestinal barrier injury and could potentially be used for therapy in clinical practice.

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Section: Inosine Induced the Inhibition Of Pathogenic Bacteria And Th...mentioning

confidence: 99%

Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms

Guo,

Tang,

Zhang

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Effect of Pseudomonas stutzeri F2 on rearing water quality and growth, innate immunity, visceral morphology and gut microbiota structure of juvenile spotted seabass (Lateolabrax maculatus)

Cited by 1 publication

References 77 publications

Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms

Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms

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