Effect of Protracted Intermittent Fasting on the Activities of Enzymes Involved in Energy Metabolism, and on the Concentrations of Glycogen, Protein and DNA in Skeletal Muscle of Obese Women

Vondra, K; Rath, R; Bass, A; Kuzela, L; Slabochowá, Z

doi:10.1159/000175718

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…The increase in the activities of phosphofructokinase and 2-oxoglutarate dehydrogenase after intravenous nutrition here and the depression of the activity of hexokinase after starvation reported by Vondra, Rath, Bass, Kuzela & Slabochova (1976) would support the latter. However, since there was no change in the mean activities of fructose bisphosphatase after feeding additional mechanisms other than those associated with nutrition may be of significance.…”

Section: Discussionsupporting

confidence: 67%

Activities of Hexokinase, Phosphofructokinase, Fructose Bisphosphatase and 2-Oxoglutarate Dehydrogenase in Muscle of Normal Subjects and Very Ill Surgical Patients

1981

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1. The activities of hexokinase, phosphofructokinase, fructose bisphosphatase and 2-oxoglutarate dehydrogenase have been measured in the vastus lateralis and rectus abdominus muscle of normal human subjects and in very ill surgical patients. 2. The activities of these enzymes in the muscle of control subjects were similar to the pattern seen in the skeletal muscle of other mammals and lower vertebrates. 3. Fructose bisphosphatase and phosphofructokinase activities were significantly lower in the muscle of ill patients although the depression of the activity of fructose bisphosphatase was much greater than that of phosphofructokinase in both muscle types of ill patients. 4. The maximum rate of cycling in the fructose 6-phosphate--fructose, 1,6-diphosphate cycle may be altered in the ill. 5. This decreased cycling may have a direct influence on the sensitivity of glycolysis to regulators such as the adenine nucleotides and may reduce the ability to maintain body temperature. 6. Increased glycogen synthesis in these muscles may indicate that the role of fructose bisphosphatase is unlikely to be solely in glycogen resynthesis.

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Section: Discussionsupporting

confidence: 67%

Activities of Hexokinase, Phosphofructokinase, Fructose Bisphosphatase and 2-Oxoglutarate Dehydrogenase in Muscle of Normal Subjects and Very Ill Surgical Patients

1981

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“…The other 12 of the 31 publications that used intermittent fasting regimes used short periods of severe energy restriction during a "fasting phase" of 2 to 7 days per week (48,51,56,57,59,60,(76)(77)(78)(79)(80)(81). Besides these 31 publications investigating intermittent fasting regimes, a further 7 of the 40 included publications used longer periods of severe energy restriction (2-12 consecutive weeks) (39,49,50,52,(82)(83)(84).…”

Section: Sample Size Formentioning

confidence: 99%

Do intermittent diets provide physiological benefits over continuous diets for weight loss? A systematic review of clinical trials

Seimon

Roekenes

Zibellini

et al. 2015

Molecular and Cellular Endocrinology

165

135

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Energy restriction induces physiological effects that hinder further weight loss. Thus, deliberate periods of energy balance during weight loss interventions may attenuate these adaptive responses to energy restriction and thereby increase the efficiency of weight loss (i.e. the amount of weight or fat lost per unit of energy deficit). To address this possibility, we systematically searched MEDLINE, PreMEDLINE, PubMed and Cinahl and reviewed adaptive responses to energy restriction in 40 publications involving humans of any age or body mass index that had undergone a diet involving intermittent energy restriction, 12 with direct comparison to continuous energy restriction. Included publications needed to measure one or more of body weight, body mass index, or body composition before and at the end of energy restriction. 31 of the 40 publications involved 'intermittent fasting' of 1-7-day periods of severe energy restriction. While intermittent fasting appears to produce similar effects to continuous energy restriction to reduce body weight, fat mass, fat-free mass and improve glucose homeostasis, and may reduce appetite, it does not appear to attenuate other adaptive responses to energy restriction or improve weight loss efficiency, albeit most of the reviewed publications were not powered to assess these outcomes. Intermittent fasting thus represents a valid--albeit apparently not superior--option to continuous energy restriction for weight loss.

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“…It may be assumed that before fasting the cycle glucose -fatty acids plays a role, fatty acids being utilized to an increased extent even under basal conditions in skeletal muscles of obese subjects. This leads to the inhibition of glucose utilization by a series of intracellular feedback regulations (Vondra, Rath and Bass 1976). The majority of authors explain this by deteriorated carbohydrate tolerance and the development of peripheral insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…More detailed knowledge of the mechanism of this adaptation is necessary for rational and sucessful treatment of obesity. In recent years, we have become involved in this problem repeatedly (Rath and Vondra 1977;Vondra and Rath 1973;Vondra and Rath 1975;Vondra, Rath, Bass, Kuzela and Slabochova 1976). The present investigation deals with the effect of a five-day complete fast on the activity of energy supplying enzymes in skeletal muscles of obese young men.…”

Section: Introductionmentioning

confidence: 95%

The Effect of Five Days' Fasting on Skeletal Muscle Enzymes in Obese Men

Vondra¹,

Bass²,

Brodan³

et al. 1983

Horm Metab Res

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The effect of 120 hours' (five days) fasting on the activity of some enzymes of energy metabolism in skeletal muscles was investigated in six obese young men. The results revealed a significant decline in the activity of the following enzymes: triosophosphate dehydrogenase (by 20%), glycerol-3-phosphate dehydrogenase (by 24%), lactate dehydrogenase (by 13%), citrate synthase (by 20%), hydroxyacyl-CoA dehydrogenase (by 40%), while the hexokinase and malate dehydrogenase activities were not significantly altered. Contrary to muscles of non-obese healthy men (Vondra, Bass, Brodan, Kuhn, Andĕl, Veselková and Vítek 1982), a smaller decline of activities of the investigated enzymes occurred together with a paradoxical change of the enzyme pattern, namely a predominance of carbohydrate catabolism and a decline of the role of fatty acids in muscle energy metabolism.

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Effect of Protracted Intermittent Fasting on the Activities of Enzymes Involved in Energy Metabolism, and on the Concentrations of Glycogen, Protein and DNA in Skeletal Muscle of Obese Women

Cited by 8 publications

References 25 publications

Activities of Hexokinase, Phosphofructokinase, Fructose Bisphosphatase and 2-Oxoglutarate Dehydrogenase in Muscle of Normal Subjects and Very Ill Surgical Patients

Activities of Hexokinase, Phosphofructokinase, Fructose Bisphosphatase and 2-Oxoglutarate Dehydrogenase in Muscle of Normal Subjects and Very Ill Surgical Patients

Do intermittent diets provide physiological benefits over continuous diets for weight loss? A systematic review of clinical trials

The Effect of Five Days' Fasting on Skeletal Muscle Enzymes in Obese Men

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