Effect of proton pump inhibitors on gastric pH in patients exposed to severe stress

Lenz, Kurt; Buder, R; Firlinger, Fritz; Lohr, G; Voglmayr, M

doi:10.1007/s00508-014-0637-y

Cited by 7 publications

(6 citation statements)

References 32 publications

(33 reference statements)

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“…The LHCb lifetime measurements presented gives a consistent and quite complete picture of the different b-hadron lifetimes. All the lifetimes reported are the most precise measurements to date and are consistent with theoretical predictions [3], as it can be see in Figure 1. The B 0 s effective lifetime measurements described in these proceedings have been included in the average shown in Figure 2.…”

Section: Discussionsupporting

confidence: 88%

“…to the B 0 lifetime measured in the flavour-specific B 0 → J/ψK * (892) 0 channel. All ratios are consistent with SM predictions [3] and with previous measurements [16]. Furthermore, the ratios…”

Section: Ratiosupporting

confidence: 91%

“…The decay width difference in the B 0 system, ∆Γ d , is sufficiently small [3] that the heavy and light mass eigenstates cannot be resolved experimentally. It can be constrained using the effective B 0 lifetime measurements in a flavour specific decay, like B 0 → J/ψK * (892) 0 , and in a decay to a CP eigenstate, like B 0 → J/ψK 0 S , as proposed in [6].…”

Section: Determination Of ∆γ Dmentioning

confidence: 99%

“…In particular, precision measurements of b-hadron lifetimes are an important test of the theoretical approach to b-hadron observables, known as Heavy Quark Expansion (HQE). In this approach the decay rate is calculated as an expansion in inverse powers of the heavy b-quark mass [1,2,3]:…”

Section: Introductionmentioning

confidence: 99%

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Lifetime measurements in $b$-hadron decays at LHCb

Dordei

2014

Preprint

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Precision lifetime measurements of b-flavoured hadrons are an important test of the validity of the theoretical tool used to determine b-hadrons observables, the Heavy Quark Expansion. Recent measurements of the B + , Λ 0 b , Ξ − b , Ξ 0 b and Ω − b hadrons lifetimes are reported. Moreover, several B 0 and B 0 s effective lifetime measurements are discussed, as well as a measurement of the decay width difference in the B 0 system, ∆Γ d . All the measurements have been performed using pp collision data collected with the LHCb detector.

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Section: Discussionsupporting

confidence: 88%

Section: Ratiosupporting

confidence: 91%

Section: Determination Of ∆γ Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lifetime measurements in $b$-hadron decays at LHCb

Dordei

2014

Preprint

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“…Нетрудно убедиться, что перечисленные диагнозы являются тяжелыми стрессовыми факторами. Можно предположить, что их воздействие обусловлено резким снижением рН желудочного сока, характерного для стрессового состояния [13]. Уменьшение аортомезентериального угла является следствием тяжело-го состояния, сопровождающегося похуданием, а не причиной заболевания.…”

Section: Discussionunclassified

Duodenal motor function in health and some diseases: A hypothesis

Levin¹,

Коршун²,

Mendelson³

2016

Ter. arkh.

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We found an important role of the sphincters (bulbo-duodenal, Kapandji, Ochsner) in the duodenal physiology. On this basis, we proposed the hypothesis defining basic patterns of the duodenal motor function. Proposed hypothesis allows us to understand how the duodenum performs important functions and provides new avenues for understanding the pathogenesis of acquired diseases of the upper gastrointestinal tract. The different forms dyskinesia of these sphincters play an important role in the pathogenesis of the SMAS, primary duodenal diverticula and sphincter Oddi dyskinesia.

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Guidelines for proton pump inhibitor prescriptions in paediatric intensive care unit

et al. 2017

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Background Stress ulcer prophylaxis (SUP) is recommended in some situations to prevent upper gastrointestinal bleeding and is a component of standard care for patients admitted to the intensive care unit (ICU). Proton pump inhibitors (PPIs), already among the most widely prescribed drug classes, are being increasingly used. Objective To describe PPI prescribing patterns and their changes after the dissemination of guidelines. Setting Paediatric ICU (PICU), Robert-Debré Teaching Hospital, Paris, France, which admits about 800 patients annually, from full-term neonates to 18-year-olds. Method Prospective observational study with two 6-week observation periods (July-August and September-October, 2013), before and after dissemination in the PICU of PPI prescribing guidelines. Main outcome measure Changes in PPI prescribing patterns (prevalence, dosage, and indication) after the guidelines. Results The number of patients admitted to the PICU was 77 (mean age 4.6 years [range 1 day-18 years]) before and 70 (mean age 3.8 years [range 1 day-17 years]) after the guidelines. During both periods, SUP was the most common reason for PPI prescribing. The proportion of patients prescribed PPIs dropped significantly, from 51% before the guidelines to 30% after the guidelines (p < 0.001). Mean daily dosage also decreased significantly, from 1.5 mg/kg/(range 0.5-4.4) to 1.1 mg/kg (range 0.7-1.8) (p < 0.002). None of the patients experienced upper gastrointestinal bleeding during either period. Conclusion Off-label PPI prescribing for SUP was common in our PICU. The introduction of guidelines was associated with a significant decrease in PPI use and dosage. This study confirms that guidelines can change PPI prescribings patterns in paediatric practice.

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Effect of proton pump inhibitors on gastric pH in patients exposed to severe stress

Abstract: High doses of PPIs are ineffective in elevating gastric pH in patients exposed to severe stress such as ultra-rapid opiate detoxification. Therefore, adequate sedoanalgesia might be the main factor responsible for preventing stress-related bleeding in critically ill patients.

Cited by 7 publications

References 32 publications

Lifetime measurements in $b$-hadron decays at LHCb

Lifetime measurements in $b$-hadron decays at LHCb

Duodenal motor function in health and some diseases: A hypothesis

Guidelines for proton pump inhibitor prescriptions in paediatric intensive care unit

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