Effect of Protein Supplementation Combined With Resistance Training on Muscle Mass, Strength and Function in the Elderly: A Systematic Review and Meta-Analysis

Hou, Liming; Lei, Yiming; Li, X.; Huo, Congde; Jia, Xin; Yang, Jie; Xu, Rong; Wang, Xiaoming

doi:10.1007/s12603-019-1181-2

Cited by 47 publications

(60 citation statements)

References 61 publications

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“…Our findings suggest that protein supplementation does not provide any greater benefit when compared to RT alone or combined with placebo in terms of muscle strength improvements in both lower and upper limbs and handgrip strength in healthy elderly adults. These results agree with previous meta-analyses conducted by Ten Haaf et al [47], Finger et al [49], and Morton et al [51], but differ from those of Hou et al [46] and Liao et al [19].…”

Section: Muscle Strengthsupporting

confidence: 89%

“…We believe that the difference between our findings and these studies lies in that Hou et al [46] and Liao et al [19] included other supplements, such as vitamin D, and their study populations were aged >50 years [46] or included hospitalized people [19]. In that sense, it could be hypothesized that PS might only provide additional benefits to RT in frail people, who are characterised by greater losses of muscle mass which may limit muscle strength development.…”

Section: Muscle Strengthmentioning

confidence: 61%

“…To our knowledge, this is the first meta-analysis that compares RT plus PS with RT alone or plus placebo supplementation in a healthy elderly population. Notably, there are similar previous studies that compared different populations, such as a younger population [45,46] or elderly hospitalized people [47]; included a combination of other supplements, such as vitamin 3, omega-3, or a dietary intake modification [19,[48][49][50][51]; or studied other outcomes related to body composition [52,53].…”

Section: Discussionmentioning

confidence: 92%

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Effectiveness of Protein Supplementation Combined with Resistance Training on Muscle Strength and Physical Performance in Elderly: A Systematic Review and Meta-Analysis

et al. 2020

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The aim of this study was to evaluate the effectiveness of the combination of resistance training (RT) and protein supplementation (PS), compared to RT alone or combined with a placebo (plS), in the improvement of muscle strength and physical performance. The search strategy in PubMed, Cochrane Library, and Web of Sciences databases found a total of 294 studies. Once inclusion and exclusion criteria were applied, 16 studies were included for the qualitative analysis. A total of 657 healthy elderly (>60 years) participants were analysed. Finally, 15 articles were included in the quantitative analysis with one being excluded due to issues with data availability. Upper-limb, lower-limb, and handgrip strength were the primary outcomes of the meta-analysis. The secondary outcomes, related to physical performance, were Short Physical Performance Battery (SPPB), gait speed, and the five-chair-rise test (5CRT). The main results of the meta-analysis show no statistical differences for upper-limb (SMD: 0.56, 95% CI: −0.09, 1.21, p = 0.09, I2 = 68%), lower-limb (SMD: 0.00, 95% CI: −0.18, 0.18, p = 1.0, I2 = 11%), and handgrip strength (SMD: 0.03, 95% CI: −0.26, 0.32, p = 0.84, I2 = 0%) between the RT + PS and the RT alone (or combined with plS). Moreover, no statistical differences were found relating to physical performance. In view of these results, protein supplementation combined with RT does not provide additional benefits compared to RT alone or with plS in healthy elderly adults.

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Section: Muscle Strengthsupporting

confidence: 89%

Section: Muscle Strengthmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 92%

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Effectiveness of Protein Supplementation Combined with Resistance Training on Muscle Strength and Physical Performance in Elderly: A Systematic Review and Meta-Analysis

et al. 2020

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“…First, we included a large number of selected studies (trials) and subjects. To the best of our knowledge, the numbers in the present study are 2-3 times higher than those in previous meta-analyses [9][10][11][12][13][14][15] . Second, dose-reactivity was described using a multivariate adjusted spline model.…”

Section: Strengths and Limitationscontrasting

confidence: 75%

“…7 According to a meta-analysis of nitrogen delivery tests to evaluate the required amount of protein, protein requirement in adults was reported to be 0.66 g/kg body weight/day. 8 However, although some randomized controlled trials (RCTs) reported an increase in skeletal muscle mass following intake of more than the required amount of protein, [9][10][11][12][13][14][15] no consistent results have been demonstrated. 12 The dose-response relationship between protein intake and muscle mass has been reported in a recent meta-analysis of RCTs.…”

Section: Introductionmentioning

confidence: 99%

Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

Tagawa¹,

Watanabe

Ito³

et al. 2020

Preprint

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Background: Lean body mass (LBM) is essential for health; however, consensus regarding the effectiveness of protein interventions in increasing LBM is lacking. Objective: Evaluate the dose-response relationship of the effects of protein on LBM. Data Sources: PubMed and Ichushi-Web databases were searched. A manual search of the references of the literature included here and in other meta-analyses was conducted. Study Selection: Randomized controlled trials evaluating the effect of protein intake on LBM were included. Data Extraction: Two researchers independently screened the abstracts; five reviewed the full-texts. Results: 5402 subjects from 105 articles were included. In the multivariate-spline model, the mean and corresponding 95% confidence intervals (CIs) for LBM increase for 0.1 g/kg body weight (BW)/day increment was 0.39 [95% CI, 0.36-0.41] kg and 0.12 [0.11-0.14] kg below and above total protein intake 1.3 g/kg BW/day, respectively. Conclusions: Our findings suggest that slightly increasing current protein intake for several months by 0.1 g/kg BW/day may increase or maintain LBM in a dose-response manner from 0.5 to 3.5 g/kg BW/day.

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Sarcopenia knowledge of geriatric rehabilitation patients is low while they are willing to start sarcopenia treatment: EMPOWER‐GR

Verstraeten,

Mashni,

van Wijngaarden

et al. 2023

J cachexia sarcopenia muscle

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BackgroundSarcopenia is prevalent in 20–50% of geriatric rehabilitation inpatients and is associated with functional dependence and mortality. The aim is to assess knowledge of geriatric rehabilitation inpatients on sarcopenia and their willingness and perceived barriers to start treatment.MethodsEnhancing Muscle POWER in Geriatric Rehabilitation (EMPOWER‐GR) is an observational cohort of geriatric rehabilitation inpatients in Amsterdam, the Netherlands. Knowledge of sarcopenia, willingness and perceived barriers to treatment were assessed with a survey among inpatients. Importance of and self‐perceived muscle health were rated using a visual analogue scale from 0 to 10. Descriptive statistics were used.ResultsInpatients' (n = 157, 59.9% female) mean age was 80.5 years (SD 7.3). Sarcopenia (European Working Group on Sarcopenia in Older People 2) prevalence was 21.7%. Five inpatients (3.2%) had heard of sarcopenia and had knowledge of its definition. Median muscle health was rated as 6 (interquartile range: 4–7). After explanation of treatment options, 67.1% were willing to start resistance exercise training (RET), 61.1% a high‐protein diet and 55.7% oral nutritional supplements (ONS). Inpatients with sarcopenia were less willing (51.6%) to start a high‐protein diet compared with inpatients without sarcopenia (77.8%) (P = 0.002); there was no difference for RET and ONS. Most reported barriers to treatment were ONS dislike (17.0%), too many other health issues (13.6%), doubts about treatment effectiveness/importance (12.9%) and RET intensity/difficulty (10.2%).ConclusionsKnowledge of sarcopenia was low, while the majority of inpatients showed willingness to start treatment. A dislike of ONS, RET difficulty and too many other health issues may reduce willingness to start treatment. Education is important to increase sarcopenia‐related health issues in geriatric rehabilitation inpatients.

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Effect of Protein Supplementation Combined With Resistance Training on Muscle Mass, Strength and Function in the Elderly: A Systematic Review and Meta-Analysis

Cited by 47 publications

References 61 publications

Effectiveness of Protein Supplementation Combined with Resistance Training on Muscle Strength and Physical Performance in Elderly: A Systematic Review and Meta-Analysis

Effectiveness of Protein Supplementation Combined with Resistance Training on Muscle Strength and Physical Performance in Elderly: A Systematic Review and Meta-Analysis

Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

Sarcopenia knowledge of geriatric rehabilitation patients is low while they are willing to start sarcopenia treatment: EMPOWER‐GR

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