Effect of prostaglandins on in vitro synthesis of progesterone and oestradiol-17β in placenta from early human pregnancy

Rao, B. K.

doi:10.1016/s0090-6980(79)80027-1

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1981

1988

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Cited by 9 publications

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“…Few comparable data exist for women. Rao (1979) has demonstrated in-vitro synthesis of oestradiol-17ß and progesterone from endogenous precursors in the human placenta from at least 5 weeks gestation, although completion of placental takeover in hormone production does not occur until closer to 7…”

Section: Discussionmentioning

confidence: 99%

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Hodges¹,

Henderson²,

Hearn³

1983

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Section: Discussionmentioning

confidence: 99%

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Hodges¹,

Henderson²,

Hearn³

1983

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Prostaglandin regulation of the content of sex hormone receptors in human decidual tissue

Yudaev

Asribekova

Karpova

et al. 1981

Neurosci Behav Physiol

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Effect of sulprostone on concentrations of progesterone, 20α-dihydroprogesterone, estrone, and estradiol in human placental tissue in the first trimester of pregnancy

et al. 1982

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Placentas were obtained from 35 healthy women whose pregnancy was terminated in the first trimester. Seventeen of them had no prostaglandin medication whereas in 18 women 500 micrograms of sulprostone was administered for cervical softening 12-14 h prior to the termination of pregnancy. Concentrations of progesterone and 20 alpha-dihydroprogesterone were determined from the extract of the placenta by liquid chromatography and those of estrone and estradiol by a radioimmunoassay. Placental progesterone concentration (6,829 +/- 469 ng/g wet weight, mean +/- SEM) was higher in the sulprostone group than in the control group (5,070 +/- 539 ng/g, p less than 0.02), but the mean concentrations of 20 alpha-dihydroprogesterone, estrone and estradiol were similar in both groups. Thus the small dose of sulprostone used in this study did not result in any great changes in placental steroidogenesis which could bring about the initiation of abortion. The increase of placental progesterone may, however, indicate that uterine contractions and impaired uteroplacental blood flow secondarily decreased the direct transfer of steroids from the placenta to the myometrium.

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Effect of prostaglandins on in vitro synthesis of progesterone and oestradiol-17β in placenta from early human pregnancy

Cited by 9 publications

References 4 publications

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Prostaglandin regulation of the content of sex hormone receptors in human decidual tissue

Effect of sulprostone on concentrations of progesterone, 20α-dihydroprogesterone, estrone, and estradiol in human placental tissue in the first trimester of pregnancy

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