Effect of prostaglandins E1, E2, and F2? and prostacyclin on local thrombosis following laser injury to the microvascular wall

Chernukh, A. M.; Éntsik, L. A.; Гомазков, О. А.

doi:10.1007/bf00837698

Cited by 1 publication

(2 citation statements)

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“…The influence of PGI2 in conditioning laser-induced phenomena in venules had al ready been observed by Chernukh et al [3] who demonstrated that PGI2 mitigated em bolism not only by reducing the number of clots, but also by delaying their appearance.…”

Section: Discussionmentioning

confidence: 98%

“…At this point, it should be underlined that Chernukh et al [3] ob served the effects of PGI2 on microthrombogenesis provoked by UV laser in an experi mental model consisting of Wistar rat mes enteric venules with an internal diameter of 34.4 ± 0.3 pm. These authors demonstrated that PGH administered in doses of 230 ng*kg"1-min_1 caused a marked reduction in the area of the thrombus, an effect which was also associated with a slowing down of the temporal evolution of microthrombi.…”

Section: Discussionmentioning

confidence: 99%

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Experimental Study of Argon Laser-Induced Microthrombosis during PGI<sub>2</sub> Infusion

et al. 1987

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In order to evaluate the Argon laser-induced microthrombogenesis during prostacyclin (PGI2) infusion on newly formed microcirculation in the rabbit ear chamber, time-space parameters have been calculated in 118 observations subdivided into 4 groups according to the type and size of the vessels irradiated. The observations were carried out without drug treatment, with continuous infusion of pH 10.5 glycine buffer and with continuous infusion of PGI₂ at the dosage of 125 ng·kg^–1·•·min^–1 diluted in the glycine buffer. The results indicated that during PGI2 infusion the size of the thrombus, measured by maximal thrombus area, was always significantly less extended than in untreated animals. Moreover, the number of emboli detached during the first 5 min after laser exposure, measured by rate of embolization, during PGI₂ infusion in venules and in the larger arterioles was smaller than in untreated animals. The vasoconstriction which usually takes place in the arteriolar vessels -upstream and downstream from the irradiated site – was in no way modified by the infusion of PGI2. Finally, it was noted that glycine buffer infusion showed an unforeseen activity on laser-induced vascular reactivity.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%