Effect of prostaglandins A-1, E-2 and F-2  on spermatogenesis in rats

Didolkar, Ashok K.; Roychowdhury, Debasish

doi:10.1530/jrf.0.0580275

Cited by 9 publications

(9 citation statements)

References 14 publications

(15 reference statements)

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“…An important difference between our results and those of Saksena et al (1 973) is an increase in testicular weight, after PGE-2 treatment in our experiment. It has been observed by us that PGE-2 particularly, instead of depressing spermatogenesis, as found by Ericsson (1 973), stimulated spermatogenesis by preventing degeneration of spermatids (Didolkar and Roychowdhury, 1980). It has been observed by us that PGE-2 particularly, instead of depressing spermatogenesis, as found by Ericsson (1 973), stimulated spermatogenesis by preventing degeneration of spermatids (Didolkar and Roychowdhury, 1980).…”

Section: Discussionmentioning

confidence: 89%

Effect of Prostaglandins A-1, E-2 and F-2a on Blood Plasma Levels of Testosterone, LH and FSH in Male Rats

et al. 2009

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Section: Discussionmentioning

confidence: 89%

Effect of Prostaglandins A-1, E-2 and F-2a on Blood Plasma Levels of Testosterone, LH and FSH in Male Rats

et al. 2009

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“…Numerous studies indicate that prostanoids, and PGE 2 in particular, regulate Leydig and Sertoli cell function, immune reactions and the vasculature, with direct or indirect effects on spermatogenesis (Free & Jaffe, 1972;Haour et al, 1979;Chantharaksri & Fuchs, 1980;Chinoy et al, 1980;Didolkar & Roychowdhury, 1980;Ishikawa et al, 2005;Ishikawa & Morris, 2006). Studies using NSAIDs that inhibit both forms of COX, such as aspirin and indomethacin, or administration of various prostaglandins, have produced conflicting data with respect to their effects on spermatogenic function (Cenedella & Crouthamel, 1973;Abbatiello et al, 1975;Biswas et al, 1978;Sanyal et al, 1980;Moskovitz et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

“…, 1979; Chantharaksri & Fuchs, 1980; Chinoy et al. , 1980; Didolkar & Roychowdhury, 1980; Kern & Maddocks, 1995; Ishikawa et al. , 2005; Ishikawa & Morris, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide‐treated rats

et al. 2009

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Celecoxib (Celebrex), an inhibitor of cyclooxygenase-2 (COX-2; prostaglandin-endoperoxide synthase 2; EC 1.14.99.1), is widely used in the treatment of chronic inflammation and pain. COX-2 is constitutively expressed in the testis, where it is responsible for prostaglandin production, so inhibition of this enzyme should have effects on testicular function. The effects of administering celecoxib (oral with feed, 0.15% w/w) for 5 weeks on normal testis function and the response to low dose (0.1 mg/kg body weight) or high dose (5.0 mg/kg) lipopolysaccharide (LPS) were examined in adult male rats. Celecoxib caused a 60% reduction in testicular interstitial fluid (IF) prostaglandin E(2) (PGE(2)) concentrations, accompanied by a compensatory increase in COX-2 mRNA expression. Celecoxib increased IF volume by 30%, but had no effect on testis weight, testis morphology or serum testosterone levels. In the celecoxib-fed rats, the dose-dependent inhibitory effects of LPS on testis weight, IF volume and serum testosterone levels were significantly diminished. However, celecoxib had no effect on COX-2 protein levels or LPS-induced expression of the inflammatory mediators interleukin-1beta, tumour necrosis factor-alpha or inducible nitric-oxide synthase. A similar lack of inhibition of LPS-induced cytokine expression by another COX-2 inhibitor, NS-398, was observed in vitro. These data indicate that celecoxib reduces intratesticular activity of COX-2 (as indicated by PGE(2) levels) and inhibits IF formation in the testis, but has no appreciable effect on steroidogenesis or spermatogenesis, at least in the short term. Celecoxib does not appear to alter the ability of the testis to mount an inflammatory response but opposes the deleterious effects of inflammation on IF formation and testosterone production. These results indicate significant roles for products of the COX-2 pathway in testicular vascular control and steroidogenesis, which may have implications for men with marginal fertility taking celecoxib for extended periods, but also highlight the potential of this drug to ameliorate testicular damage caused by systemic or local inflammation.

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“…It is suggested that PGE2 may be involved in the later stages of spermatogenesis, i.e. conversion of spermatocytes to spermatids (17). Aitken et al reported that PGE2 treatment increases human sperm motility and penetrating ability (18).…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin E synthase is regulated in postnatal mouse testis

Kong¹

2012

Front Biosci

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Effect of prostaglandins A-1, E-2 and F-2 on spermatogenesis in rats

Cited by 9 publications

References 14 publications

Effect of Prostaglandins A-1, E-2 and F-2a on Blood Plasma Levels of Testosterone, LH and FSH in Male Rats

Effect of Prostaglandins A-1, E-2 and F-2a on Blood Plasma Levels of Testosterone, LH and FSH in Male Rats

Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide‐treated rats

Prostaglandin E synthase is regulated in postnatal mouse testis

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