Effect of prostaglandin E1 on renal hemodynamics in nondiuretic and volume-expanded dogs

Arendshorst, WJ; Pa, Johnston; Ee, Selkurt

doi:10.1152/ajplegacy.1974.226.1.218

Cited by 22 publications

(8 citation statements)

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“…Many studies employing pharma cological administration of prostaglandins or prostaglandin synthesis inhibition by nonsteroidal anti-inflammatory agents have been performed. When PGE is added to the renal circulation in the anesthetized dog, renal vasodilation results with enhanced renal blood How, especially to inner cortical areas [4,6]. Other investigators have noted a natriuretic response to intra-arterial or intravenous prostaglandin administration [15].…”

Section: Discussionmentioning

confidence: 99%

“…For ex ample, both renal hemodynamics as well as intrarenal distribution of blood flow have been shown to be altered in acute prepara tions by administration of exogenous prosta glandins or following prostaglandin synthe sis inhibition [4,6,25]. In conscious animals however, renal hemodynamic effects of prostaglandin synthesis inhibition are mini mal [34], Although there is not a substantial effect of cyclo-oxygenase inhibition on renal he modynamics, renal tubular function may be affected.…”

Section: Introductionmentioning

confidence: 99%

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Antidiuresis and Decreased Sodium Excretion during Cyclo-Oxygenase Inhibition in the Conscious Dog

Walker¹

1983

Kidney Blood Press Res

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Studies were undertaken to further elucidate the role of endogenous prostaglandins in normal renal function in the awake dog. Meclofenamate (2 mg/kg and 2 mg/kg/h, i.v.) was administered after control measurements. Parallel time control experiments were also performed. Inhibition of renal prostaglandin synthesis was documented by significant reduction in urinary prostaglandin E₂ excretion rate. Urine flow and sodium excretion were reduced by meclofenamate infusion. In addition, fractional excretion of sodium was reduced, implying enhanced sodium reabsorption during prostaglandin synthesis inhibition. Renal hemodynamics, glomerular filtration and systemic hemodynamics were unaffected. It is concluded that endogenous prostaglandin release is important in influencing sodium and water excretion in the conscious dog.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidiuresis and Decreased Sodium Excretion during Cyclo-Oxygenase Inhibition in the Conscious Dog

Walker¹

1983

Kidney Blood Press Res

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“…However, by deter mining both the plasma and the red cell volumes [33], one circumvents the mistake of introducing the system ic hematocrit when calculating whole blood flow from plasma flow. The major problems with this method are: (a) tissue damage [33]: this can be obviated by using external detection as done by Arendshorst et al [34]: (b) interpretation: in the medulla, many tracer mole cules pass the detector tw'ice due to the countercurrent flow pattern. Obviously, this distortion becomes less as the measuring site approaches the papillary tip.…”

Section: Transit Time-indicator Dilutionmentioning

confidence: 99%

Evaluation of Methods for Estimating Renal Medullary Blood Flow

Hansell¹

1992

Kidney Blood Press Res

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Although only 10-15% of renal blood flow enters the medulla, renal medullary hemodynamics have been implicated as a key factor for the ability of the kidney to excrete concentrated or diluted urine and to be involved in sodium homeostasis. Due to the obvious importance of medullary hemodynamics, several methods have been developed or modified for estimating regional renal blood flow. The aim of the present paper is to evaluate critically the most commonly used methods available today. Those which are considered in this paper are: (1) albumin accumulation (Lilienfield), (2) rubidium-86 uptake, (3) transit time-indicator dilution, (4) red cell velocity tracking, (5) red cell flux (fluorescently labeled red cells) and (6) laser-Doppler flowmetry. Depending on the method of choice, the reported control values for renal medullary blood flow differ up to tenfold. Overall, it appears that the discrepancies in values obtained from the different methods will not be resolved until the methods are compared directly in the same animal and during different experimental conditions. Furthermore, one needs to understand and describe accurately the involved errors so that proper corrections can be made. It seems likely, however, that the majority of the techniques can be used to study relative changes, but attempts should not be made to draw conclusions about the absolute flow value. In this regard the laser-Doppler method seems to be superior in its simplicity of use and its large advantage of continuous and relatively noninvasive measurement.

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“…The mech anism responsible for increased blood flow following triple typhoid vaccine remains ob scure [5,6], although it appears to be unrelated to hyperthermia [6,22] and is independent of renal innervation [14,16]. The renal vasodila tation may be either due to the direct local effects of the pyrogen or the action of a vaso depressor material on the renal vasculature [31], The similarity of the renal hemodynamic changes following the administration of pros taglandins to those observed during pyrogeninduced renal hyperemia suggested the possi bility of pyrogenic activation of renal prosta glandin synthesis and subsequent renal vaso dilatation [2,33]. The reported elevations of renal venous prostaglandins or prostaglandin like material during endotoxic shock [1,7] lends support to this suggested role for pros taglandins in renal hyperemia induced by pyro gens.…”

Section: Introductionmentioning

confidence: 99%

Pyrogenic Renal Hyperemia: The Role of Prostaglandins

Gagnon¹,

Ramwell²,

Flamenbaum³

1978

Nephron

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The intravenous administration of triple typhoid vaccine to anesthetized dogs resulted in a significant increase in renal blood flow accompanied by a modest decline in systemic blood pressure. This renal hyperemia was associated with elevated renal secretory rates of renin and prostaglandin E and F. Measurements of the intracortical distribution of radiolabeled microspheres revealed a progressive decrease in outer cortical blood flow rates and a progressive increase in inner cortical flow rates. When meclofenamate, an inhibitor of prostaglandin synthetase, was administered concomitantly with triple typhoid vaccine renal hyperemia did not develop. The renal renin secretory rate increased modestly and intracortical renal blood flow was not redistributed. The increased renal blood flow after triple typhoid vaccine administration to unanesthetized dogs was also reversed by meclofenamate. The marked increase in prostaglandin secretion by the kidney during renal hyperemia following triple typhoid vaccine administration (pyrogen), and the effect of meclofenamate, is consonant with a role for increased renal synthesis and release of prostaglandins.

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Effect of prostaglandin E1 on renal hemodynamics in nondiuretic and volume-expanded dogs

Cited by 22 publications

References 0 publications

Antidiuresis and Decreased Sodium Excretion during Cyclo-Oxygenase Inhibition in the Conscious Dog

Antidiuresis and Decreased Sodium Excretion during Cyclo-Oxygenase Inhibition in the Conscious Dog

Evaluation of Methods for Estimating Renal Medullary Blood Flow

Pyrogenic Renal Hyperemia: The Role of Prostaglandins

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