Effect of Prostaglandin E in Multiple Experimental Models. III. Effect on Response to Septic Challenge

Induction by interleukin 6 of Gs-coupled prostaglandin E2 receptors in rat hepatocytes mediating a prostaglandin E2-dependent inhibition of the hepatocyte’s acute phase response

“…However, their exact role remains obscure. In different in vivo studies prostanoids have been shown to enhance, 11,12 to be without significance, 13,14 or to attenuate 15 the acute phase response. In light of in vitro experiments the attenuation of the acute phase response seems to be most likely, because prostaglandin E 2 (PGE 2 ) that is released from Kupffer cells in response to proinflammatory signals can inhibit the synthesis of IL-6 16 and tumor necrosis factor ␣ 17 in an autocrine feedback inhibition loop.…”

Effect of prostaglandin E in multiple experimental models: V. Effect on tumor/host interaction

“…This effect would be expected not to decrease the serum amino acid levels as we found, but rather to increase them. This discrepancy may be explained by a report demonstrating increased production of hepatic acute-phase proteins following dPGE administration [24]. Such an increased rate of production could mean that the liver is preferentially removing these amino acids and utilizing them for protein synthesis, thus depriving the remainder of the animal and its tumor of these necessary protein precursors.…”

Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin E2-Rezeptoren

“…Die Rolle von Prostanoiden in der Modulation der Akutphase-Antwort bleibt unklar. In verschiedenen in vivo-Studien wurde gezeigt, daß Prostanoide die Akutphase-Antwort sowohl verstärken können (Revhaug et al 1988;Whicher et al 1984), ohne Einfluß auf sie sind (Holtslag et al 1988;Limaos et al 1985) als auch eine hemmende Wirkung auf sie haben (Waymack und Mason 1989). Im Licht von in vitro-Untersuchungen jedoch scheint eine inhibierende Wirkung am wahrscheinlichsten, da PGE 2 z.…”